Biocompatible nanomicelles for sensitive detection and photodynamic therapy of early-stage cancer

2021 ◽  
Author(s):  
Hailin Zhou ◽  
Zhongyuan Qi ◽  
Pei Pei ◽  
Wenhao Shen ◽  
Yanxiang Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Blood Vessel ◽  
Early Stage ◽  
Detection Technique ◽  
Sensitive Detection ◽  
Early Stage Cancer ◽  
Sensitive Detection Technique

The lack of sensitive detection technique and agents for early-stage tumors, which are characterized with small size, juvenile blood vessel and scarce secreted markers, has hampered the timely cancer therapy...

Photodynamic therapy for precancer and early stage cancer of the uterine cervix with fertility preservation

2011 ◽  
Vol 8 (2) ◽  
pp. 218
Author(s):  
M. Sakamoto ◽  
S. Okamoto ◽  
K. Miyake ◽  
Y. Koyamatsu ◽  
T. Akiya ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fertility Preservation ◽  
Uterine Cervix ◽  
Early Stage ◽  
Early Stage Cancer

scholarly journals A novel detection technique of polyamide binding sites by photo-induced electron transfer in BrU substituted DNA

2015 ◽  
Vol 51 (77) ◽  
pp. 14485-14488 ◽  
Author(s):  
Abhijit Saha ◽  
Fumitaka Hashiya ◽  
Seiichiro Kizaki ◽  
Sefan Asamitsu ◽  
Kaori Hashiya ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Binding Sites ◽  
Detection Technique ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Photo Induced Electron Transfer ◽  
Highly Sensitive Detection ◽  
Sensitive Detection Technique

We demonstrate a highly sensitive detection technique of polyamide binding sites using the photochemistry of BrU labeled DNA.

scholarly journals Current Status and Future Perspectives of the Photodynamic Therapy for Early Stage Cancer and Dysplasia of the Uterine Cervix

2012 ◽  
Vol 33 (2) ◽  
pp. 117-121
Author(s):  
Masaru Sakamoto ◽  
Ryusuke Kaya ◽  
Kiyohiko Miyake ◽  
Yasuko Koyamatsu ◽  
Makoto Motegi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Uterine Cervix ◽  
Early Stage ◽  
Current Status ◽  
Future Perspectives ◽  
Early Stage Cancer

scholarly journals Anthelmintic resistance of gastrointestinal cattle nematodes

2013 ◽  
Vol 82 (3) ◽  
pp. 113-123 ◽  
Author(s):  
J. De Graef ◽  
E. Claerebout ◽  
P. Geldhof
Keyword(s):  
Anthelmintic Resistance ◽  
Early Stage ◽  
Control Strategies ◽  
Small Ruminants ◽  
Sensitive Detection ◽  
Current Status ◽  
Diagnostic Assays ◽  
Cooperia Oncophora ◽  
Near Future ◽  
Sensitive Detection Technique

Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products. In Belgium, Cooperia oncophora is the most common cattle nematode in which resistance, especially against macrocyclic lactones, occurs. Once resistance has been diagnosed, a change to another drug with a different mode of action is advised. However, effective anthelmintics will be hardly available in the near future. Therefore, it is important that farmers and veterinarians find a balance between achieving good parasite control and the sustainability of their control strategies. In this way, anthelmintic resistance may be delayed, and the effectiveness of anthelmintic drugs may be prolonged. This requires sensitive detection tools. With a sensitive detection technique, anthelmintic resistance can be diagnosed in a very early stage. Hence, the spread of resistance alleles in the parasite population may be prevented. In this review, different diagnostic assays for the detection of anthelmintic resistance are discussed, an overview is given of the current status of anthelmintic resistance in Belgian cattle, and measures are suggested to avoid or delay the development of anthelmintic resistance.

scholarly journals Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Nafiseh Sobhani ◽  
Ali Akbar Samadani
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Malignant Tumors ◽  
Early Stage ◽  
Acquired Resistance ◽  
Resistance Mechanisms ◽  
Treatment Modalities ◽  
Main Body ◽  
Valuable Treatment ◽  
Natural Tissue

Abstract Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemotherapy, photodynamic adjuvant therapy is of great importance. Photodynamic therapy (PDT) as a relatively noninvasive therapeutic method utilizes the irradiation of an appropriate wavelength which is absorbed by a photosensitizing agent in the presence of oxygen. Main body of the abstract In this procedure, a series of events lead to the direct death of malignant cells such as damage to the microvasculature and also the induction of a local inflammatory function. PDT has participated with other treatment modalities especially in the early stage of malignant tumors and has resulted in decreasing morbidity besides improving survival rate and quality of life. High spatial resolution of PDT has attracted considerable attention in the field of image-guided photodynamic therapy combined with chemotherapy of multidrug resistance cancers. Although PDT outcomes vary across the different tumor types, minimal natural tissue toxicity, minor systemic effects, significant reduction in long-term disease, lack of innate or acquired resistance mechanisms, and excellent cosmetic effects, as well as limb function, make it a valuable treatment option for combination therapies. Short conclusion In this review article, we tried to discuss the potential of PDT in the treatment of some dermatologic and solid tumors, particularly all its important mechanisms.

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