Self-assembled lyotropic liquid crystal gel for osteoarthritis treatment via anti-inflammation and cartilage protection

2021 ◽  
Author(s):  
Liling Mei ◽  
Hui Wang ◽  
Jintian Chen ◽  
Ziqian Zhang ◽  
Feng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Effective Treatment ◽  
Drug Delivery System ◽  
Cartilage Degeneration ◽  
Lyotropic Liquid Crystal ◽  
Joint Disease ◽  
Osteoarthritis Treatment ◽  
Anti Inflammation ◽  
And Cartilage

Osteoarthritis (OA) is a chronic joint disease with occurrence of articular inflammation and cartilage degeneration. An ideal drug delivery system for effective treatment of OA should integrate inflammation alleviation with...

scholarly journals Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Keda Liu ◽  
Dianjian Zhang ◽  
Wei Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Symptomatic Treatment ◽  
Cartilage Degeneration ◽  
Joint Disease ◽  
Research Progress ◽  
System A ◽  
Reactive Hyperplasia

Osteoarthritis (OA) is a bone and joint disease with pathological characteristics such as articular cartilage degeneration injury and synovial and subchondral bone reactive hyperplasia. Once cartilage is damaged, it is difficult to repair it by itself. Current clinical practice is mainly limited to symptomatic treatment, not changing the degenerative process of osteoarthritis. The important goal of nanomedicine is targeted delivery. Nanoparticles (NPs) can provide many unique potential functions for the targeted treatment of arthritis. This review summarizes the research progress of nanomaterials as a drug delivery system in the treatment of osteoarthritis from three aspects: (1) the etiology of OA and the current research status of applying nanoparticles to treat OA, (2) the construction of osteoarthritis models, and (3) the classification of nanoparticle-based drug delivery systems.

Lyotropic liquid crystal systems in drug delivery

2010 ◽  
Vol 15 (23-24) ◽  
pp. 1032-1040 ◽  
Author(s):  
Chenyu Guo ◽  
Jun Wang ◽  
Fengliang Cao ◽  
Robert J. Lee ◽  
Guangxi Zhai
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Lyotropic Liquid Crystal

Advances in lyotropic liquid crystal systems for skin drug delivery

2020 ◽  
Vol 17 (12) ◽  
pp. 1781-1805
Author(s):  
Ana Vitoria Pupo Silvestrini ◽  
Angelo Luis Caron ◽  
Juliana Viegas ◽  
Fabíola Garcia Praça ◽  
Maria Vitoria Lopes Badra Bentley
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Lyotropic Liquid Crystal

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

Nanoscale ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 6394-6399 ◽  
Author(s):  
Weiwei Zhao ◽  
Hua Wang ◽  
Haimang Wang ◽  
Ying Han ◽  
Zhibo Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Visible Light ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Functional ◽  
Osteoarthritis Treatment ◽  
Anti Inflammation

Visible light-responsive biodegradable mesoporous silica nanoparticles (bMSNs-AZO/CD-PMPC) were developed for osteoarthritis treatment, which simultaneously achieved lubrication enhancement and anti-inflammation.

scholarly journals Effect of Transcutol and Stearylamine on Ibuprofen Hydrophilic Gel for Transdermal Delivery

2018 ◽  
Vol 8 (01) ◽  
Author(s):  
Mahdi Abd Zair ◽  
D. Prasanthi ◽  
Amoolya Chennuri ◽  
Zainab Rahi Hanthal ◽  
P K Lakshmi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Skin Permeation ◽  
Skin Irritation ◽  
Oral Drug ◽  
Anti Inflammatory ◽  
Hydrophilic Gel ◽  
Anti Inflammation

Transdermal drug delivery system (TDDS) shows promising results when compared with oral drug delivery system mainly by eliminating the first pass metabolism and by improving the bioavailability of drug. Hydrophilic gels are networks of polymer chains that are sometimes found as colloidal gels in which water is the dispersion medium. Ibuprofen, nonsteroidal anti-inflammatory drug used to relieve pain, reduces fever and anti-inflammation. The purpose of present research is to demonstrate the influence of various enhancers (transcutol and stearylamine) in various concentrations on percutaneous permeation of ibuprofen hydrophilic gel from HPMC K4M & HPMC K100M gel formulation. Gelling agents at various concentrations were preliminary screened for gel consistency. The control and the prepared gels were evaluated for clarity, homogeneity, spreadability, extrudability, drug content, invitro diffusion, ex-vivo permeation, skin irritation, anti-inflammatory activity and stability studies. All formulations have shown better physicochemical properties. Ex-vivo skin permeation studies reveals that the (IBU29) formulated using HPMC K4M 6%, transcutol 40% and stearylamine 4% as permeation enhancers has shown maximum drug release of 86.4 % for 24hrs. Permeability parameters like flux were found to be 1940.68±0.06µg/cm²/hr, permeability coefficient was found 31 ×10-3 cm/hr and Q24 was found to be 5240.82±0.06µg/cm² and enhancement ratio of 13.06 over pure drug. Skin irritation studies showed irritation potential of “0” score thus providing to be non-irritant. The anti-inflammation studies were performed with inflammation induced by carrageenan 1% w/v solution. Optimized formulation (IBU29) showed highest reduction of inflammation comparable to marketed preparation BRUGESIC GEL®. The formulations were stable at room temperature for 1 month.Key words: Transdermal gel, Ibuprofen, HPMC K4M, HPMC K100M, Penetration- enhancer..

scholarly journals Development, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Poly-(ε-caprolactone) Microcapsules Prepared by Ultrasonic Atomization for Intra-Articular Administration

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 249 ◽  
Author(s):  
Asteria Luzardo-Álvarez ◽  
Iván Lamela-Gómez ◽  
Francisco Otero-Espinar ◽  
José Blanco-Méndez
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Responses ◽  
Polymer Concentration ◽  
Joint Disease ◽  
Oral Drug ◽  
Ultrasonic Atomization

Intra-articular administration of drugs to the joint in the treatment of joint disease has the potential to minimize the systemic bioavailability and the usual side-effects associated with oral drug administration. In this work, a drug delivery system is proposed to achieve an anti-inflammatory local effect using resveratrol (RSV). This study aims to develop microcapsules made of poly-(ε-caprolactone) (PCL) by ultrasonic atomization to preserve the antioxidant activity of RSV, to prevent its degradation and to suppress the inflammatory response in activated RAW 264.7 macrophages. An experimental design was performed to build a mathematical model that could estimate the effect of nozzle power and polymer concentration on particle size and encapsulation efficiency. RSV-loaded microcapsules showed adequate morphology, particle size, and loading efficiency properties. RSV formulations exhibited negligible cytotoxicity and an efficient amelioration of inflammatory responses, in terms of Nitric Oxide (NO), ROS (Reactive Oxygen Species), and lipid peroxidation in macrophages. Thus, RSV-loaded microcapsules merit consideration as a drug delivery system suitable for intra-articular administration in inflammatory disorders affecting the joint.

scholarly journals Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis

2021 ◽  
Vol 22 (6) ◽  
pp. 2838
Author(s):  
Ichiro Sekiya ◽  
Hisako Katano ◽  
Nobutake Ozeki
Keyword(s):  
Synovial Fluid ◽  
Mode Of Action ◽  
Cartilage Degeneration ◽  
Matrix Synthesis ◽  
Gene Expressions ◽  
Culture Dish ◽  
Culture Model ◽  
Anti Inflammation ◽  
Human Clinical Study ◽  
And Cartilage

We have been studying mesenchymal stem cells (MSCs) in synovial fluid and the intra-articular injection of synovial MSCs in osteoarthritis (OA) knees. Here, mainly based on our own findings, we overview the characteristics of endogenous MSCs in the synovial fluid of OA knees and their mode of action when injected exogenously into OA knees. Many MSCs similar to synovial MSCs were detected in the synovial fluid of human OA knees, and their number correlated with the radiological OA grade. Our suspended synovium culture model demonstrated the release of MSCs from the synovium through a medium into a non-contacting culture dish. In OA knees, endogenous MSCs possibly mobilize in a similar manner from the synovium through the synovial fluid and act protectively. However, the number of mobilized MSCs is limited; therefore, OA progresses in its natural course. Synovial MSC injections inhibited the progression of cartilage degeneration in a rat OA model. Injected synovial MSCs migrated into the synovium, maintained their MSC properties, and increased the gene expressions of TSG-6, PRG-4, and BMP-2. Exogenous synovial MSCs can promote anti-inflammation, lubrication, and cartilage matrix synthesis in OA knees. Based on our findings, we have initiated a human clinical study of synovial MSC injections in OA knees.

scholarly journals Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giselle Pidde ◽  
Milton Y. Nishiyama ◽  
Ursula Castro de Oliveira ◽  
Isadora M. Villas-Boas ◽  
Adriana F. Paes-Leme ◽  
...  
Keyword(s):  
Bone Structure ◽  
Meta Analysis ◽  
Joint Stiffness ◽  
Cartilage Degeneration ◽  
Joint Space ◽  
Joint Disease ◽  
Homologous Proteins ◽  
Pharmacological Targets ◽  
Human Proteins ◽  
And Cartilage

AbstractThe joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.

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