scholarly journals Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Keda Liu ◽  
Dianjian Zhang ◽  
Wei Wang

Osteoarthritis (OA) is a bone and joint disease with pathological characteristics such as articular cartilage degeneration injury and synovial and subchondral bone reactive hyperplasia. Once cartilage is damaged, it is difficult to repair it by itself. Current clinical practice is mainly limited to symptomatic treatment, not changing the degenerative process of osteoarthritis. The important goal of nanomedicine is targeted delivery. Nanoparticles (NPs) can provide many unique potential functions for the targeted treatment of arthritis. This review summarizes the research progress of nanomaterials as a drug delivery system in the treatment of osteoarthritis from three aspects: (1) the etiology of OA and the current research status of applying nanoparticles to treat OA, (2) the construction of osteoarthritis models, and (3) the classification of nanoparticle-based drug delivery systems.

Author(s):  
Asif Eqbal ◽  
Vaseem Ahamad Ansari ◽  
Abdul Hafeez ◽  
Farogh Ahsan ◽  
Mohd Imran ◽  
...  

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.


2017 ◽  
Vol 18 (10) ◽  
Author(s):  
Vinay Pandit ◽  
Ajay Kumar ◽  
Mahendra S. Ashawat ◽  
Chander P. Verma ◽  
Pravin Kumar

2018 ◽  
Vol 9 (1) ◽  
pp. 2604-2635
Author(s):  
Ankit Dugad . ◽  
Pravin Nalawade . ◽  
Ravindra Thakhre . ◽  
Sujit Kakade .

2013 ◽  
Vol 3 (2) ◽  
Author(s):  
Ravindra B Borade ◽  
Yogesh Y Mahajan ◽  
Nilesh P Jadhav ◽  
Jaiprakash V Kokane ◽  
Md. Rageeb Md. Usman ◽  
...  

2018 ◽  
Vol 97 ◽  
pp. 489-495 ◽  
Author(s):  
Liziane O.F. Monteiro ◽  
Renata S. Fernandes ◽  
Caroline M.R. Oda ◽  
Sávia C. Lopes ◽  
Danyelle M. Townsend ◽  
...  

2020 ◽  
Vol 13 (1) ◽  
pp. 2287-2308 ◽  
Author(s):  
Yen Pin Yew ◽  
Kamyar Shameli ◽  
Mikio Miyake ◽  
Nurul Bahiyah Bt Ahmad Khairudin ◽  
Shaza Eva Bt Mohamad ◽  
...  

2020 ◽  
Vol 10 (4) ◽  
pp. 278-284
Author(s):  
Sarjavalagi Vishal Gopal ◽  
Prabhat Kumar Chaurasia ◽  
Harshitha Arun Pardhe ◽  
Singh Suryansh Santosh ◽  
Narayan Sah Sonar

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