When drug nanocarriers miss their target: extracellular diffusion and cell uptake are not enough to be effective

2021 ◽  
Author(s):  
Vincent Pautu ◽  
Heng Zhao ◽  
Angelika Mielcarek ◽  
Anna Balasso ◽  
Patrick Couvreur ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Synthetic Methods ◽  
Cell Uptake ◽  
Therapeutic Molecules ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Drug Nanocarriers

Biocompatible nanoscale iron carboxylate metal organic frameworks (nanoMOFs) already demonstrated their ability to efficiently deliver various therapeutic molecules. The versatility of the synthetic methods and functionalization strategies could further improve...

scholarly journals Recent Developments in the Synthesis and Applications of Metal Organic Framework: A Concise Review

2021 ◽  
Vol 33 (5) ◽  
pp. 956-962
Author(s):  
Chandan Adhikari ◽  
Rehana Farooq
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
Electrochemical Sensors ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Inorganic Materials ◽  
Synthetic Methods ◽  
Concise Review ◽  
Metal Organic ◽  
Organic Framework

Metal organic frameworks (MOFs) are one of those compounds which have drawn attention in various applications due to their several interesting properties like tunable shape, size, pore size, easy functionalization, high surface area, pore volume, etc. Metal organic frameworks due to their uniform structures, tunable porosity, wide variety and stability on various topology, geometry, dimension and chemical functions of the molecular network give a remarkable structural diversity in comparison to other porous materials. This enables scientists to handle numerous framework structures, porosity and functionality effectively. The unique structural architecture and tunable properties of MOF’s makes them an interesting hybrid material consisting of organic and inorganic materials. MOF can be randomly constructed like Lego bricks and superior in terms of versatility in comparisson to other porous materials. A number of MOFs containing a wide variety of metal e.g. zinc, copper, iron, aluminium, magnesium, chromium, zirconium, gadolinium, manganese are gaining rapid growth in commercial markets for gas storage, adsorption, separation and catalytic applications. This concise review emphasizes various synthetic methods e.g. solvothermal process, hydrothermal synthesis, electrochemical synthesis, microwave synthesis, sonochemical synthesis, mechanochemical synthesis, of metal organic framework developed in the last few decades. It also addresses various applications of metal organic framework e.g. hydrogen storage, gas adsorption, drug delivery systems and bioimaging agents, biocatalysts, biosensors, electrochemical sensors, etc. It also comments on various challenges and futuristic applications of metal organic frameworks in various field e.g. liquid wate management, gaseous waste management, sunlight assisted catalysis, water purification, building materials, electronic devices, battery technologies, targeted drug delivery, solar cells, etc. of science and technology in coming decades.

scholarly journals Host-Guest Interactions Between Metal–Organic Frameworks and Air-Sensitive Complexes at High Temperature

2021 ◽  
Vol 9 ◽  
Author(s):  
Bo Huang ◽  
Zhe Tan
Keyword(s):  
High Temperature ◽  
Metal Complexes ◽  
High Temperatures ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Chemical Vapor ◽  
Chemical Vapor Infiltration ◽  
Synthetic Methods ◽  
Infiltration Process ◽  
Metal Organic

The host-guest chemistry of metal–organic frameworks (MOFs) has been attracting increasing attention owing to the outstanding properties derived from MOFs-guests combinations. However, there are large difficulties involved in the syntheses of the host-guest MOF systems with air-sensitive metal complexes. In addition, the behaviors on host-guest interactions in the above systems at high temperature are not clear. This study reported the synthetic methods for host-guest systems of metal–organic framework and air-sensitive metal complexes via a developed chemical vapor infiltration process. With the synchrotron X-ray powder diffraction (XRPD) measurements and Fourier Transform infrared spectroscopy (FTIR), the successful loadings of Fe(CO)5 in HKUST-1 and NH2-MIL-101(Al) have been confirmed. At high temperatures, the structural and chemical componential changes were investigated in detail by XRPD and FTIR measurements. HKUST-1 was proven to have strong interaction with Fe(CO)5 and resulted in a heavy loading amount of 63.1 wt%, but too strong an interaction led to deformation of HKUST-1 sub-unit under heating conditions. NH2-MIL-101(Al), meanwhile, has a weaker interaction and is chemically inert to Fe(CO)5 at high temperatures.

scholarly journals New insights on the supramolecular structure of highly porous core–shell drug nanocarriers using solid-state NMR spectroscopy

RSC Advances ◽  
2019 ◽  
Vol 9 (56) ◽  
pp. 32472-32475
Author(s):  
Marianna Porcino ◽  
Ioanna Christodoulou ◽  
Mai Dang Le Vuong ◽  
Ruxandra Gref ◽  
Charlotte Martineau-Corcos
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Solid State Nmr ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Porous Core ◽  
Engineered Surfaces ◽  
Metal Organic ◽  
Drug Nanocarriers ◽  
Highly Porous

Nano-sized metal–organic frameworks (nanoMOFs), with engineered surfaces to enhance the targeting of the drug delivery, have proven efficient as drug nanocarriers.

Metal–organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging

2017 ◽  
Vol 53 (11) ◽  
pp. 1840-1843 ◽  
Author(s):  
Yan Zhang ◽  
Chaoqun Liu ◽  
Faming Wang ◽  
Zhen Liu ◽  
Jinsong Ren ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Immune Response ◽  
Magnetic Resonance ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Resonance Imaging ◽  
Cpg Odns ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Organic Framework

Iron carboxylate metal–organic frameworks supporting CpG ODNs were fabricated to enhance both the immune response of the CpG ODNs and the ability to image them using T2-magnetic resonance imaging.

Nanoscale Metal-Organic Frameworks for Tumor Phototherapy

2021 ◽  
Author(s):  
Xuan Huang ◽  
Xu Sun ◽  
Weili Wang ◽  
Qing Shen ◽  
Qian Shen ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Organic Frameworks ◽  
Organic Ligands ◽  
Synthetic Methods ◽  
Metal Organic ◽  
Coordination Bonds

Metal-Organic Frameworks (MOFs) are constructed from metal ions/cluster nodes and functional organic ligands through coordination bonds. Owing to the advantages of diverse synthetic methods, easy modification after synthesis, large adsorption...

scholarly journals Metal-Organic Frameworks: Synthetic Methods and Potential Applications

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 310
Author(s):  
Catherine P. Raptopoulou
Keyword(s):  
Metal Organic Frameworks ◽  
Structural Diversity ◽  
Two Dimensions ◽  
Three Dimensions ◽  
Synthetic Methods ◽  
High Porosity ◽  
Potential Applications ◽  
Metal Organic ◽  
Gas Molecules ◽  
Solvent Molecules

Metal-organic frameworks represent a porous class of materials that are build up from metal ions or oligonuclear metallic complexes and organic ligands. They can be considered as sub-class of coordination polymers and can be extended into one-dimension, two-dimensions, and three-dimensions. Depending on the size of the pores, MOFs are divided into nanoporous, mesoporous, and macroporous items. The latter two are usually amorphous. MOFs display high porosity, a large specific surface area, and high thermal stability due to the presence of coordination bonds. The pores can incorporate neutral molecules, such as solvent molecules, anions, and cations, depending on the overall charge of the MOF, gas molecules, and biomolecules. The structural diversity of the framework and the multifunctionality of the pores render this class of materials as candidates for a plethora of environmental and biomedical applications and also as catalysts, sensors, piezo/ferroelectric, thermoelectric, and magnetic materials. In the present review, the synthetic methods reported in the literature for preparing MOFs and their derived materials, and their potential applications in environment, energy, and biomedicine are discussed.

A combined bottom-up and top-down strategy to fabricate lanthanide hydrate@2D MOF composite nanosheets for direct white light emission

2021 ◽  
Author(s):  
Jianping Tang ◽  
Zhenxin Liang ◽  
Mengyi Huang ◽  
Shaodong Su ◽  
Yuehong Wen ◽  
...  
Keyword(s):  
Composite Materials ◽  
White Light ◽  
Light Emission ◽  
Metal Organic Frameworks ◽  
Synthetic Methods ◽  
Top Down ◽  
Host Matrix ◽  
Guest Molecules ◽  
Functional Composite ◽  
Metal Organic

Metal–organic frameworks (MOFs) have been demonstrated as an excellent host matrix to encapsulate diverse guest molecules for fabricating functional composite materials. Many synthetic methods have been explored to prepare white-light...

scholarly journals Chitosan-engineered metal–organic frameworks as oral drug nanocarriers

2017 ◽  
Vol 73 (a2) ◽  
pp. C1281-C1281
Author(s):  
Patricia Horcajada ◽  
Tania Hidalgo ◽  
Monica Gimenez-Marques ◽  
Rosana Simon-Vazquez ◽  
Jose Avila ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic ◽  
Drug Nanocarriers

Nanoscale iron carboxylate metal organic frameworks as drug carriers for magnetically aided intracellular delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76861-76866 ◽  
Author(s):  
Komal Sethi ◽  
Shalini Sharma ◽  
Indrajit Roy
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Intracellular Delivery ◽  
Drug Carriers ◽  
Metal Organic ◽  
Drug Delivery Applications ◽  
Iron Carboxylate

We report the synthesis, characterisation, and magnetically controlled drug delivery applications of drug-encapsulated iron carboxylate nanoscale metal organic frameworks (NMOFs).

The chemistry of titanium-based metal–organic frameworks

2017 ◽  
Vol 41 (23) ◽  
pp. 14030-14043 ◽  
Author(s):  
Ha L. Nguyen
Keyword(s):  
Crystal Structures ◽  
Metal Organic Frameworks ◽  
Synthetic Methods ◽  
Metal Organic

The chemistry of Ti-based MOFs, including their synthetic methods, crystal structures, topological evaluation, and promising applications, is precisely summarized and discussed.

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