Nanoscale iron carboxylate metal organic frameworks as drug carriers for magnetically aided intracellular delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76861-76866 ◽  
Author(s):  
Komal Sethi ◽  
Shalini Sharma ◽  
Indrajit Roy
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Intracellular Delivery ◽  
Drug Carriers ◽  
Metal Organic ◽  
Drug Delivery Applications ◽  
Iron Carboxylate

We report the synthesis, characterisation, and magnetically controlled drug delivery applications of drug-encapsulated iron carboxylate nanoscale metal organic frameworks (NMOFs).

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery

2008 ◽  
Vol 130 (21) ◽  
pp. 6774-6780 ◽  
Author(s):  
Patricia Horcajada ◽  
Christian Serre ◽  
Guillaume Maurin ◽  
Naseem A. Ramsahye ◽  
Francisco Balas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Porous Metal ◽  
Controlled Drug Delivery ◽  
Metal Organic

Diffusion as a function of guest molecule length and functionalization in flexible metal–organic frameworks

2016 ◽  
Vol 3 (4) ◽  
pp. 355-361 ◽  
Author(s):  
B. Zheng ◽  
L. L. Wang ◽  
L. Du ◽  
Y. Pan ◽  
Z. Lai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Guest Molecule ◽  
Metal Organic Frameworks ◽  
Chemical Separation ◽  
Efficient Design ◽  
Metal Organic ◽  
Drug Delivery Applications ◽  
Flexible Metal

Understanding guest diffusion in nanoporous host–guest systems is crucial in the efficient design of metal–organic frameworks (MOFs) for chemical separation and drug delivery applications.

scholarly journals Tuning Crystal Structures of Iron-Based Metal–Organic Frameworks for Drug Delivery Applications

ACS Omega ◽  
2020 ◽  
Vol 5 (7) ◽  
pp. 3418-3427 ◽  
Author(s):  
Hao Pham ◽  
Kimberly Ramos ◽  
Andy Sua ◽  
Jessica Acuna ◽  
Katarzyna Slowinska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crystal Structures ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Iron Based ◽  
Drug Delivery Applications

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

2018 ◽  
Vol 24 (64) ◽  
pp. 17148-17154 ◽  
Author(s):  
Hong Dong ◽  
Gui‐Xin Yang ◽  
Xin Zhang ◽  
Xiang‐Bin Meng ◽  
Jing‐Li Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic ◽  
Targeted Drug

Mesoporous iron-carboxylate metal–organic frameworks synthesized by the double-template method as a nanocarrier platform for intratumoral drug delivery

2017 ◽  
Vol 5 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Zhengfei Wu ◽  
Na Hao ◽  
Hai Zhang ◽  
Zhaoyuan Guo ◽  
Rong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Therapeutic Efficacy ◽  
Metal Organic Frameworks ◽  
Template Method ◽  
Local Chemotherapy ◽  
Metal Organic ◽  
Iron Carboxylate ◽  
Intratumoral Drug Delivery

The DOX-loaded mesoMOFs exhibit excellent therapeutic efficacy and low side effects in local chemotherapy.

scholarly journals MIL-53 (Al) metal-organic frameworks as potential drug carriers

2021 ◽  
Vol 2058 (1) ◽  
pp. 012015
Author(s):  
O Yu Griaznova ◽  
I V Zelepukin ◽  
G V Tikhonowski ◽  
V N Kolokolnikov ◽  
S M Deyev
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Loading ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Drug Carriers ◽  
Microwave Assisted Synthesis ◽  
Promising Candidate ◽  
Metal Organic

Abstract One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.

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