Dual-targeted and MRI-guided photothermal therapy via iron-based nanoparticles-incorporated neutrophils

2021 ◽  
Author(s):  
Jing Wang ◽  
Tianxiao Mei ◽  
Yang Liu ◽  
Yifan Zhang ◽  
Ziliang Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Local Temperature ◽  
Tumor Site ◽  
Mri Guided ◽  
Iron Based

Nanoparticle-mediated photothermal therapy (PTT) has shown the promising capability for tumor therapy through the high local temperature at the tumor site generated by photothermal agent (PTA) under visible or near-infrared...

Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy

2020 ◽  
Vol 8 (36) ◽  
pp. 8189-8206 ◽  
Author(s):  
Xueping Kong ◽  
Guofeng Wan ◽  
Bao Li ◽  
Lixin Wu
Keyword(s):  
Functional Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Imaging Techniques ◽  
Tumor Therapy ◽  
Recent Advances ◽  
Bio Imaging

The recent advances of polyoxometalate clusters in terms of near infrared photothermal properties for targeted tumor therapy have been summarized while the combined applications with various bio-imaging techniques and chemotherapies are reviewed.

Near-infrared-II Light Excitation Thermosensitive Liposomes for Photoacoustic Imaging Guided and Enhanced Photothermal-Chemo Synergistic Tumor Therapy

2021 ◽  
Author(s):  
Yeneng Dai ◽  
Wenyu Du ◽  
Diya Gao ◽  
Haowei Zhu ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Great Success ◽  
Light Excitation ◽  
Thermosensitive Liposomes

Although the great success of photothermal therapy (PTT), it still suffers from many obstacles, such as the limited penetration depth of light, thermoresistance of tumor, as well as the limitations...

A mesoporous polydopamine nanoparticle enables highly efficient manganese encapsulation for enhanced MRI-guided photothermal therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yan Wu ◽  
Yu Huang ◽  
Chunlai Tu ◽  
Fengren Wu ◽  
Gangsheng Tong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Resonance Imaging ◽  
Highly Efficient ◽  
Enhanced Mri ◽  
Mri Guided ◽  
Theranostic Agents ◽  
Magnetic Resonance Imaging Mri

Theranostic agents based on magnetic resonance imaging (MRI) and photothermal therapy (PTT) play an important role in tumor therapy. However, available theranostic agents are confronting great challenges in the issues...

scholarly journals Designing highly stable ferrous selenide-black phosphorus nanosheets heteronanostructure via P-Se bond for MRI-guided photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xuanru Deng ◽  
Hongxing Liu ◽  
Yuan Xu ◽  
Leung Chan ◽  
Jun Xie ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Water Solubility ◽  
Tumor Therapy ◽  
Lone Pair ◽  
Black Phosphorus ◽  
Photothermal Conversion ◽  
Mri Guided ◽  
Theranostic Agents ◽  
Lone Pair Electrons

Abstract Background The design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is imminent. Results Herein, black phosphorus nanosheets (BPs) covalently with mono-dispersed and superparamagnetic ferrous selenide (FeSe2) to construct heteronanostructure nanoparticles modified with methoxy poly (Ethylene Glycol) (mPEG-NH2) to obtain good water solubility for MRI-guided photothermal tumor therapy is successfully designed. The mechanism reveals that the enhanced photothermal conversion achieved by BPs-FeSe2-PEG heteronanostructure is attributed to the effective separation of photoinduced carriers. Besides, through the formation of the P-Se bond, the oxidation degree of FeSe2 is weakened. The lone pair electrons on the surface of BPs are occupied, which reduces the exposure of lone pair electrons in air, leading to excellent stability of BPs-FeSe2-PEG. Furthermore, the BPs-FeSe2-PEG heteronanostructure could realize enhanced T2-weighted imaging due to the aggregation of FeSe2 on BPs and the formation of hydrogen bonds, thus providing accurate PTT guidance and generating hyperthermia to inhabit tumor growth under NIR laser with negligible toxicity in vivo. Conclusions Collectively, this work offers an opportunity for fabricating BPs-based heteronanostructure nanomaterials that could simultaneously enhance photothermal conversion efficiency and photostability to realize MRI-guided cancer therapy. Graphic abstract

scholarly journals Double Drug-Loaded and pH/Thermal Sensitive Multifunctional Drug Delivery System for Tumor Photoacoustic Imaging-Guided Enhanced Chemo/Photothermal Therapy

2019 ◽  
Author(s):  
Jun Wang ◽  
Na Chen ◽  
Kai Liu ◽  
Yu Tu ◽  
Weitao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
Heterogeneous Distribution

Abstract Background: Owing to the tunability of longitudinal surface plasmon resonance (LSPR), ease of synthesizing small size and excellent stability, AuNRs have been developed as photothermal agents for cancer therapy. However, PTT alone could not kill cancer cells completely due to the local heterogeneous distribution of heat in tumors, penetration depth of light, light scattering and absorption. In addition, the treatment systems based on AuNRs hold disadvantages of loading one antitumor drug or a low therapeutic efficiency. Therefore, the construction of the AuNRs theranostic system to achieve imaging-guided dual drug delivery and enhanced photothermal therapy for tumor still remains a great challenge.Methods: The AuNRs were prepared using a seedless method. A mesoporous silica shell layer was coated on the surface of the AuNRs by sol-gel method. Double anticancer drugs, DOX and Btz, were loaded into the AuNRs@MSN nanoparticles through physical absorption and covalent conjugation, respectively.Results: The release of DOX and Btz is found pH/thermal dual responsive in vitro. Compared with AuNRs@MSN, PDA-AuNRs@MSN exhibits an increased near-infrared (NIR) absorption at 808 nm and an enhanced photothermal effect. In contrast to chemotherapy or photothermal therapy alone, the integrated D/B-PDA-AuNRs@MSN nanoparticles show higher cell apoptosis and enhanced tumor treatment efficacy in vitro and in vivo.Conclusions: In this study, we designed a double-drug loading, enhanced chemo/photothermal therapy and pH/thermal responsive drug delivery system for photoacoustic (PA) imaging-guided tumor therapy. We believe that the multifunctional D/B-PDA-AuNRs@MSN theranostic probe could serve as an effective probe for the treatment of cancers.

scholarly journals Photothermal Therapy for the Treatment of Glioblastoma: Potential and Preclinical Challenges

2021 ◽  
Vol 10 ◽  
Author(s):  
Chiara Bastiancich ◽  
Anabela Da Silva ◽  
Marie-Anne Estève
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Imaging Techniques ◽  
Resistance Mechanisms ◽  
Infrared Light ◽  
Tumor Site ◽  
Distinctive Features ◽  
Power Intensity ◽  
Medical Need ◽  
Conventional Drug

Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. However, its development is hampered by the distinctive features of this tumor. Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. Subsequently, a near infrared light irradiating the head must cross multiple barriers to reach the tumor site without causing any local damage. Its power intensity needs to be within the safety limit and its penetration depth should be sufficient to induce deep and localized hyperthermia and achieve tumor destruction. To properly monitor the therapy, imaging techniques that can accurately measure the increase in temperature within the brain must be used. In this review, we report and discuss recent advances in nanoparticle-mediated plasmonic photothermal therapy for GBM treatment and discuss the preclinical challenges commonly faced by researchers to develop and test such systems.

Internal and External Triggering Mechanism of “Smart” Nanoparticle-Based DDSs in Targeted Tumor Therapy

2018 ◽  
Vol 24 (15) ◽  
pp. 1639-1651 ◽  
Author(s):  
Xian-ling Qian ◽  
Jun Li ◽  
Ran Wei ◽  
Hui Lin ◽  
Li-xia Xiong
Keyword(s):  
Targeted Delivery ◽  
Tumor Therapy ◽  
Burst Release ◽  
Tumor Site ◽  
Chemotherapeutic Drugs ◽  
Triggering Mechanism ◽  
Triggering Factors ◽  
Or Genes

Background: Anticancer chemotherapeutics have a lot of problems via conventional Drug Delivery Systems (DDSs), including non-specificity, burst release, severe side-effects, and damage to normal cells. Owing to its potential to circumventing these problems, nanotechnology has gained increasing attention in targeted tumor therapy. Chemotherapeutic drugs or genes encapsulated in nanoparticles could be used to target therapies to the tumor site in three ways: “passive”, “active”, and “smart” targeting. Objective: To summarize the mechanisms of various internal and external “smart” stimulating factors on the basis of findings from in vivo and in vitro studies. Method: A thorough search of PubMed was conducted in order to identify the majority of trials, studies and novel articles related to the subject. Results: Activated by internal triggering factors (pH, redox, enzyme, hypoxia, etc.) or external triggering factors (temperature, light of different wavelengths, ultrasound, magnetic fields, etc.), “smart” DDSs exhibit targeted delivery to the tumor site, and controlled release of chemotherapeutic drugs or genes. Conclusion: In this review article, we summarize and classify the internal and external triggering mechanism of “smart” nanoparticle-based DDSs in targeted tumor therapy, and the most recent research advances are illustrated for better understanding.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

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