Aptamer-gold nanoparticles-signal probe bioconjugates amplify electrochemical signal for the detection of prostate specific antigen

2021 ◽  
Author(s):  
Mengrao Li ◽  
Wenjuan Zhang ◽  
Yuzhong Zhang
Keyword(s):  
Gold Nanoparticles ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Cancer Biomarkers ◽  
Electrochemical Immunosensor ◽  
Au Nps ◽  
Electrochemical Signal ◽  
Signal Probe ◽  
Design Protocol

In this work, we reported a simple and sensitive electrochemical immunosensor for cancer biomarkers PSA detection. In design protocol, gold nanoparticles (Au NPs) were used a carrier to load aptamer...

An electrochemical immunosensor for prostate specific antigen using nitrogen-doped graphene as a sensing platform

2019 ◽  
Vol 11 (16) ◽  
pp. 2183-2189 ◽  
Author(s):  
Wenwen Meng ◽  
Wenjuan Zhang ◽  
JunJun Zhang ◽  
Xi Chen ◽  
Yuzhong Zhang
Keyword(s):  
Gold Nanoparticles ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Au Nps ◽  
Nitrogen Doped ◽  
Sensing Platform ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

In this study, a sensitive electrochemical immunosensor for prostate specific antigen (PSA) detection is described using nitrogen-doped graphene (NG) and gold nanoparticles (Au NPs) as a sensing interface.

Initial Study of Thin-Film Derived Gold Nanoparticles (Au NPs) Surface Plasmon Resonance (SPR) Based Prostate-Specific Antigen (PSA) Detection

2020 ◽  
Vol 18 (11) ◽  
pp. 781-784
Author(s):  
M. Dhanunjaya ◽  
T. Sonklin ◽  
Pimchanok Leuasoongnoen ◽  
Sanong Suksaweang ◽  
Pattanaphong Janphuang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Surface Plasmon Resonance ◽  
Prostate Specific Antigen ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Specific Antigen ◽  
Initial Study ◽  
Peak Position ◽  
Localized Surface Plasmon ◽  
Au Nps

The gold nanoparticles (Au NPs) localized surface plasmon resonance (LSPR) based detection of prostate-specific antigen (PSA) biomarker was carried out in this work. Au NPs on Si and quartz substrates were synthesized by DC magnetron sputtering method followed by conventional annealing protocol. The functionalization of antibody and PSA with Au NPs was evaluated using a simple drop-cost method. The SPR peak intensity was found to be proportional to the PSA concentration. The redshift in SPR peak position might be owing to the change in refractive index around the Au NPs with the conjugation of antibody and further additional binding of specific PSA at different concentrations.

Heparin-gold Nanoparticles and Liquid Crystal Applied in Label-free Electrochemical Immunosensor for Prostate-specific Antigen

2017 ◽  
Vol 30 (2) ◽  
pp. 353-360 ◽  
Author(s):  
Lucas Talamini ◽  
Nicole Zanato ◽  
Eduardo Zapp ◽  
Daniela Brondani ◽  
Eduard Westphal ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Liquid Crystal ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free

Sandwich-type electrochemical immunosensor for ultrasensitive detection of prostate-specific antigen using palladium-doped cuprous oxide nanoparticles

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 84698-84704 ◽  
Author(s):  
Yanguang Chu ◽  
Huan Wang ◽  
Hongmin Ma ◽  
Dan Wu ◽  
Bin Du ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Cuprous Oxide ◽  
Au Nanoparticles ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Oxide Nanoparticles ◽  
Ultrasensitive Detection ◽  
Au Nps ◽  
Cuprous Oxide Nanoparticles ◽  
Sandwich Type

A new and facile sandwich-type electrochemical immunosensor is proposed for the ultrasensitive detection of prostate-specific antigen (PSA) based on Au nanoparticles (Au NPs) and palladium-doped cuprous oxide nanoparticles (Pd@Cu2O NPs).

Engineering WS2-Au-HRP assisted-multiple signal amplification strategy for chemiluminescence immunoassay of prostate specific antigen

2021 ◽  
Author(s):  
Juntao Cao ◽  
Li-Zhen Zhao ◽  
Wen-Sheng Zhang ◽  
Shu-Hui Ma ◽  
Yan-Ming Liu
Keyword(s):  
Gold Nanoparticles ◽  
Horseradish Peroxidase ◽  
Prostate Specific Antigen ◽  
Signal Amplification ◽  
Specific Antigen ◽  
Tungsten Disulfide ◽  
Chemiluminescence Immunoassay ◽  
Au Nps ◽  
Multiple Signal ◽  
Amplification Strategy

A novel chemiluminescence (CL) immunosensor using functionalized Tungsten disulfide nanosheets (WS2 NSs)-gold nanoparticles (Au NPs)-horseradish peroxidase (WS2-Au-HRP) as multiple signal amplification probe was developed for prostate specific antigen (PSA) analysis....

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

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