Observation of inflammation-induced mitophagy during stroke by a mitochondria-targeting two-photon ratiometric probe

The Analyst ◽  
2021 ◽  
Author(s):  
Fei Cheng ◽  
Taotao Qiang ◽  
Longfang Ren ◽  
Tianyu Liang ◽  
Xiaoyang Gao ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Visual Tool ◽  
Ratiometric Probe ◽  
Mitochondria Targeting

The probe we developed is the first visual tool capable of accurate real-time monitoring of mitophagy during stroke.

A water-soluble benzoxazole-based probe: Real-time monitoring PPi via situ reaction by two-photon cells imaging

Talanta ◽  
2019 ◽  
Vol 195 ◽  
pp. 158-164 ◽  
Author(s):  
Dan Liu ◽  
Sheng Liu ◽  
Xinyu Zhang ◽  
Qiong Zhang ◽  
Jianhua Yu ◽  
...  
Keyword(s):  
Real Time ◽  
Water Soluble ◽  
Real Time Monitoring ◽  
Two Photon

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

A reversible ratiometric two-photon lysosome-targeted probe for real-time monitoring of pH changes in living cells

2017 ◽  
Vol 5 (24) ◽  
pp. 4768-4773 ◽  
Author(s):  
Weifang Luo ◽  
Huie Jiang ◽  
Xiaoliang Tang ◽  
Weisheng Liu
Keyword(s):  
Real Time ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Ph Changes ◽  
Two Photon

A reversible ratiometric two-photon lysosome-targeted probe that can monitor real-time pH changes in living cells.

Acidity-triggered zwitterionic prodrug nano-carriers with AIE properties and amplification of oxidative stress for mitochondria-targeted cancer theranostics

2019 ◽  
Vol 10 (8) ◽  
pp. 983-990 ◽  
Author(s):  
Junhuai Xu ◽  
Bin Yan ◽  
Xiaosheng Du ◽  
Junjie Xiong ◽  
Mi Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Delivery ◽  
Real Time ◽  
Real Time Monitoring ◽  
Cancer Theranostics ◽  
Mitochondria Targeting

A TPE-based polyurethane prodrug has been established for mitochondria-targeting drug delivery and real-time monitoring.

Real-time monitoring of intracellular nitric oxide using a long-wavelength-emitting probe via one-photon or two-photon excitation

2019 ◽  
Vol 7 (11) ◽  
pp. 3246-3252 ◽  
Author(s):  
Changquan Tang ◽  
Mingxue Wang ◽  
Xiaoying Shang ◽  
Xueyuan Chen ◽  
Deguang Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Real Time ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Long Wavelength ◽  
Two Photon ◽  
Turn On ◽  
Photon Excitation ◽  
Endogenous Nitric Oxide ◽  
Two Photon Excitation

A long-wavelength-emitting fluorescent turn-on probe is developed for monitoring exogenous or endogenous nitric oxide in living cells.

A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

2020 ◽  
Vol 56 (69) ◽  
pp. 9986-9989
Author(s):  
Amit Kumar Singh ◽  
Moumita Kundu ◽  
Samrat Roy ◽  
Biswajit Roy ◽  
Sk. Sheriff Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photon Absorption ◽  
Cancer Drug ◽  
Real Time Monitoring ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Anti Cancer

A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release.

Real-time monitoring of two-photon photopolymerization for use in fabrication of microfluidic devices

Lab on a Chip ◽  
2009 ◽  
Vol 9 (6) ◽  
pp. 819-827 ◽  
Author(s):  
Michael Stoneman ◽  
Michael Fox ◽  
Chaoyang Zeng ◽  
Valerică Raicu
Keyword(s):  
Real Time ◽  
Microfluidic Devices ◽  
Real Time Monitoring ◽  
Two Photon

Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probe

2016 ◽  
Vol 52 (97) ◽  
pp. 14007-14010 ◽  
Author(s):  
Cheol Ho Heo ◽  
Myoung Ki Cho ◽  
Seunggun Shin ◽  
Tae Hyeon Yoo ◽  
Hwan Myung Kim
Keyword(s):  
Quantitative Analysis ◽  
Real Time ◽  
Endocytic Pathway ◽  
Real Time Monitoring ◽  
Pathway Activity ◽  
Two Photon ◽  
Ph Values ◽  
Luminal Ph

An EGF-conjugated two-photon probe for real-time monitoring and quantitative analysis of luminal pH values during endocytic pathway activity was reported.

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