Multifunctional titanium phosphate carriers for enhancing drug delivery and evaluating real-time therapeutic efficacy of a hydrophobic drug component in Euphorbia kansui

The Analyst ◽  
2021 ◽  
Vol 146 (5) ◽  
pp. 1620-1625
Author(s):  
Da Luo ◽  
Yi Zhang ◽  
Minyu Wang ◽  
Chen Zhu ◽  
Yue Yao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Fluorescence Intensity ◽  
Therapeutic Efficacy ◽  
Caspase 3 ◽  
Titanium Phosphate ◽  
Hydrophobic Drug ◽  
Hydrophilic Drug ◽  
Euphorbia Kansui ◽  
Delivery Efficiency

TiP–PEG/peptide nanocarriers were constructed to enhance hydrophilic drug delivery efficiency and determine real-time therapeutic efficacy according to the fluorescence intensity of FAM triggered by caspase-3.

Multifunctional titanium phosphate nanoparticles for site-specific drug delivery and real-time therapeutic efficacy evaluation

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 3103-3110 ◽  
Author(s):  
Fang-Fang Cheng ◽  
Panpan Sun ◽  
Wei-Wei Xiong ◽  
Yi Zhang ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Real Time ◽  
Therapeutic Efficacy ◽  
Titanium Phosphate ◽  
Specific Drug ◽  
Efficacy Evaluation ◽  
Site Specific

Folic acid (FA)-functionalized DHE-modified TiP (TiP-PAH-DHE-FA) nanoparticles were synthesized for site-specific drug delivery and real-time therapeutic efficacy evaluation.

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

2018 ◽  
Vol 47 ◽  
pp. 62-66 ◽  
Author(s):  
Yuko Okamoto ◽  
Kazuaki Taguchi ◽  
Mina Sakuragi ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Hydrophobic Drug ◽  
Delivery Efficiency

scholarly journals Peptide-Mediated Liposomal Doxorubicin Enhances Drug Delivery Efficiency and Therapeutic Efficacy in Animal Models

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83239 ◽  
Author(s):  
De-Kuan Chang ◽  
Pi-Chun Li ◽  
Ruei-Min Lu ◽  
Wann-Neng Jane ◽  
Han-Chung Wu
Keyword(s):  
Drug Delivery ◽  
Animal Models ◽  
Therapeutic Efficacy ◽  
Liposomal Doxorubicin ◽  
Delivery Efficiency

Doxorubicin-loaded fluorescent carbon dots with PEI passivation as a drug delivery system for cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (33) ◽  
pp. 17222-17237
Author(s):  
Yu Hailing ◽  
Lv Xiufang ◽  
Wu Lili ◽  
Li Baoqiang ◽  
Huang Kaichen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Growth Inhibition ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Therapeutic Efficacy ◽  
Apoptosis Induction ◽  
Fluorescent Carbon Dots

CD-PEI-mediated doxorubicin specifically targets HCC tumors, enabling real-time monitoring and therapeutic efficacy through growth inhibition and apoptosis induction.

Retention and Transport of Hydrophobic and Hydrophilic Drug Surrogate Molecules in Coronary Arteries Measured Nondestructively With Photoacoustic Ultrasound

2013 ◽  
Author(s):  
Joseph T. Keyes ◽  
Leonardo G. Montilla ◽  
Russel S. Witte ◽  
Jonathan P. Vande Geest
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Coronary Arteries ◽  
Local Drug Delivery ◽  
Drug Eluting Stents ◽  
Systemic Effects ◽  
Chemical Polarization ◽  
Design And Implementation ◽  
Hydrophilic Drug ◽  
Drug Eluting

The design and implementation of local drug delivery mechanisms in cardiovascular applications provides a method by which localized action can occur without potentially problematic systemic effects. This has been especially relevant in the case of drug-eluting stents (DESs). It has been previously shown that the degree of chemical polarization can significantly change the degree of transport and the degree of vascular retention of drugs. Understanding how these differences occur in real-time, and nondestructively, can better help guide the design of such pharmaceuticals. Previous work by our laboratory has indicated differences in transport based on location within the coronary tree (Fig. 1) [1].

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

2018 ◽  
Vol 15 (5) ◽  
pp. 652-657 ◽  
Author(s):  
Ramachandran Deepika ◽  
Koyeli Girigoswami ◽  
Ramachandran Murugesan ◽  
Agnishwar Girigoswami
Keyword(s):  
Drug Delivery ◽  
Divalent Cation ◽  
Polymer Nanoparticles ◽  
Delivery Efficiency

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Real-time quantitative monitoring of in vitro nasal drug delivery by a nasal epithelial mucosa-on-a-chip model

2021 ◽  
Author(s):  
Hanieh Gholizadeh ◽  
Hui Xin Ong ◽  
Peta Bradbury ◽  
Agisilaos Kourmatzis ◽  
Daniela Traini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Nasal Drug Delivery ◽  
Quantitative Monitoring

Crown Monitoring: Trace the dynamic changes of caspase-3 and H2O2 in real-time imaging based on FRET/SERS

2021 ◽  
pp. 113539
Author(s):  
Qiao-Yan Jiang ◽  
Ximin Cui ◽  
Yang Sun ◽  
Zhengsheng Mao ◽  
Jie Wang ◽  
...  
Keyword(s):  
Real Time ◽  
Caspase 3 ◽  
Dynamic Changes ◽  
Real Time Imaging
Sign in / Sign up

Export Citation Format

Share Document