Recognition mechanism of molecularly imprinted polymers by aggregation-induced emission

2020 ◽  
Vol 8 (39) ◽  
pp. 13574-13581
Author(s):  
Yuwei Wu ◽  
Jiang Liu ◽  
Wenbin Huang ◽  
Zikai He ◽  
Jia Zhou ◽  
...  
Keyword(s):  
Solid State ◽  
Functional Groups ◽  
Sorption Capacity ◽  
Molecularly Imprinted Polymers ◽  
Molecular Size ◽  
Recognition Mechanism ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Aggregation Induced Emission ◽  
Solid State Fluorescence

AIEgens were adopted as templates to separately investigate the effects of functional groups and molecular size on the imprinting process and sorption capacity. The possibility of using solid-state fluorescence for quantification was proved.

scholarly journals Preparation of Chitosan Molecularly Imprinted Polymers and the Recognition Mechanism for Adsorption of Alpha-Lipoic Acid

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 312 ◽  
Author(s):  
Long Xu ◽  
Ze-Xin Zhao ◽  
Yun-An Huang ◽  
Qiu-Jin Zhu
Keyword(s):  
Lipoic Acid ◽  
Molecularly Imprinted Polymers ◽  
Selective Adsorption ◽  
Dynamics Simulation ◽  
Chitosan Oligosaccharide ◽  
Alpha Lipoic Acid ◽  
Recognition Mechanism ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Kinetics And Isotherms

Two effective molecularly imprinted polymers for the adsorption of alpha-lipoic acid (ALA) were synthesized by the cross-linking of chitosan with epichlorohydrin (ECH) and glutaraldehyde (GLU), respectively, in the presence of ALA as template molecules. Investigations on the molar ratios of ALA and chitosan (–NH2) in the preparation of chitosan molecularly imprinted polymers (MIPs) were carried out with a factor of ALA rebinding capabilities. The surface morphology and chemical properties of the polymers were characterized. The optimized MIPs crosslinked by ECH (MIPs–ECH) and MIPs crosslinked by GLU (MIPs–GLU) had adsorption capabilities of 12.09 mg/g and 19.72 mg/g for ALA, respectively. The adsorption behaviors of two kinds of chitosan MIPs including adsorption kinetics and isotherms were investigated in detail. Adsorption and kinetic binding experiments showed that the prepared MIPs–ECH and MIPs–GLU had selective adsorption and excellent affinity for ALA. In addition, the possible binding models between ALA and chitosan oligosaccharide were predicted by molecular dynamics simulation.

Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

2020 ◽  
Vol 8 (35) ◽  
pp. 7987-7993
Author(s):  
Tetsuro Saeki ◽  
Eri Takano ◽  
Hirobumi Sunayama ◽  
Yuri Kamon ◽  
Ryo Horikawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Recognition ◽  
Functional Groups ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Cancer Biomarker ◽  
Glycoprotein P ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

scholarly journals Molecularly Imprinted Polymers for Selective Extraction of Oblongifolin C from Garcinia yunnanensis Hu

2017 ◽  
Author(s):  
Wang Liping ◽  
Fu Wenwei ◽  
Shen Yunhui ◽  
Tan Hongsheng ◽  
Xu Hongxi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Density Functional ◽  
Solid Phase ◽  
Water Solution ◽  
Gradient Elution ◽  
Selective Extraction ◽  
Molar Ratio ◽  
Recognition Mechanism ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Molecularly imprinted polymers (MIPs) were synthesized and applied for the selective extraction of oblongifolin C (OC) from fruit extracts of Garcinia yunnanensis Hu. A series of experiments and computational approaches were employed to improve the efficiency of screening for optimal MIP systems in the study. The molar ratio (1:4) was chosen at last based on the comparison of the binding energy of the complexes between the template (OC) and functional monomers using density functional theory (DFT) at the RI-PBE-D3-gCP/def2-TZVP level of theory. The binding characterization and the molecular recognition mechanism of MIPs were further explained using the molecular modeling method and NMR and IR spectra data. The reusability of this approach was demonstrated in over 20 batch rebinding experiments. 140.5 mg of OC (>95% purity) was obtained from the 5 g extracts with 2 g of MIPs with the best binding properties through gradient elution program from 35% to 70% methanol-water solution. At the same time, another structural analog, 46.5 mg of guttiferone K (GK) (>88% purity), was also obtained by the gradient elution procedure. Our results showed that the structural analogs could be separated from the crude extracts by the molecularly imprinted solid-phase extraction (MISPE) using a gradient elution procedure for the first time.

scholarly journals Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids

RSC Advances ◽  
2019 ◽  
Vol 9 (34) ◽  
pp. 19712-19719
Author(s):  
Jie Zuo ◽  
Xingyuan Zhang ◽  
Xinyu Li ◽  
Zhiwei Li ◽  
Zongren Li ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Functional Groups ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Tropane Alkaloids ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Monoethyl fumarate with two functional groups was introduced to prepare a MIP for the separation of scopolamine from tropane alkaloids.

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