scholarly journals Regulation of protein‐binding activities of molecularly imprinted polymers via post‐imprinting modifications to exchange functional groups within the imprinted cavity

2017 ◽  
Vol 31 (3) ◽  
Author(s):  
Hirobumi Sunayama ◽  
Yukiya Kitayama ◽  
Toshifumi Takeuchi
Keyword(s):  
Protein Binding ◽  
Functional Groups ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Determination of protein binding affinities within hydrogel-based molecularly imprinted polymers (HydroMIPs)

2014 ◽  
Vol 16 (29) ◽  
pp. 15483-15489 ◽  
Author(s):  
Hazim F. EL-Sharif ◽  
Daniel M. Hawkins ◽  
Derek Stevenson ◽  
Subrayal M. Reddy
Keyword(s):  
Protein Binding ◽  
Molecularly Imprinted Polymers ◽  
Dissociation Constants ◽  
Binding Affinities ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Polymer Hydrogels ◽  
Protein Dissociation ◽  
Cognate Protein

Selective synthetic MIP recognition of a range of bio-significant proteins. Comparison of functional acrylamide-based polymer hydrogels as MIPs. MIP–protein dissociation constants within the micro-molar range. AFM measurements exhibited specific MIP interactions with cognate protein.

Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

2020 ◽  
Vol 8 (35) ◽  
pp. 7987-7993
Author(s):  
Tetsuro Saeki ◽  
Eri Takano ◽  
Hirobumi Sunayama ◽  
Yuri Kamon ◽  
Ryo Horikawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Recognition ◽  
Functional Groups ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Cancer Biomarker ◽  
Glycoprotein P ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

scholarly journals Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids

RSC Advances ◽  
2019 ◽  
Vol 9 (34) ◽  
pp. 19712-19719
Author(s):  
Jie Zuo ◽  
Xingyuan Zhang ◽  
Xinyu Li ◽  
Zhiwei Li ◽  
Zongren Li ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Functional Groups ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Tropane Alkaloids ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Monoethyl fumarate with two functional groups was introduced to prepare a MIP for the separation of scopolamine from tropane alkaloids.

A New Mechanistic Diagram for Molecularly Imprinted Polymers

2003 ◽  
Vol 787 ◽  
Author(s):  
David A. Spivak
Keyword(s):  
Functional Groups ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Complex Structure ◽  
Shape Selectivity ◽  
Solution Phase ◽  
Template Molecule ◽  
Polymer Complex ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

ABSTRACTA new mechanistic diagram describing the non-covalent molecular imprinting process is put forth in the text. A significant consequence of the new mechanistic picture is that the pre-polymer complex structure does not necessarily reflect the structure of the final binding sites in the polymer. Two independent studies are presented in combined form that support the suggested changes to the mechanistic diagram. In the first study, the maximum number of functional groups surrounding the template molecule in solution are shown to be less than the average number of functional groups in the binding sites of the polymers. In the second study, shape selectivity is shown to be an important contributor to molecular recognition by the imprinted polymers; which is significant because contributions of shape cannot be predicted by the solution phase pre-polymer complex.

Recognition mechanism of molecularly imprinted polymers by aggregation-induced emission

2020 ◽  
Vol 8 (39) ◽  
pp. 13574-13581
Author(s):  
Yuwei Wu ◽  
Jiang Liu ◽  
Wenbin Huang ◽  
Zikai He ◽  
Jia Zhou ◽  
...  
Keyword(s):  
Solid State ◽  
Functional Groups ◽  
Sorption Capacity ◽  
Molecularly Imprinted Polymers ◽  
Molecular Size ◽  
Recognition Mechanism ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Aggregation Induced Emission ◽  
Solid State Fluorescence

AIEgens were adopted as templates to separately investigate the effects of functional groups and molecular size on the imprinting process and sorption capacity. The possibility of using solid-state fluorescence for quantification was proved.

scholarly journals Selective recognition of methotrexate by molecularly imprinted polymers

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Manuela Curcio ◽  
Ortensia Ilaria Parisi ◽  
Giuseppe Cirillo ◽  
Umile Gianfranco Spizzirri ◽  
Francesco Puoci ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Functional Groups ◽  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
High Selectivity ◽  
Selective Recognition ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractThe aim of this study is the preparation of molecularly imprinted polymers with high selectivity for metotrexate (MTX), a useful antineoplastic drug widely employed in clinical trials. Methacrylic acid, 2-(dimethylamino)ethyl methacrylate and a mixture of them were tested as functional monomers in order to optimize the performance of imprinted materials. The specificity and the selectivity of imprinted polymers was tested by performing rebinding experiments in water at pH 7.4. The best results were obtained by employing both functional monomers in the polymeric feed. In this way, each monomer interacts with complementary functionalities on template molecule, stabilizing the prepolymerization complex and minimizing the repulsive effects (due to the ionization of functional groups) in the rebinding media.

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