Constructing a biomimetic nanocomposite with the in situ deposition of spherical hydroxyapatite nanoparticles to induce bone regeneration

2021 ◽  
Vol 9 (10) ◽  
pp. 2469-2482
Author(s):  
Tao Song ◽  
Fengxin Zhao ◽  
Yuyi Wang ◽  
Dongxiao Li ◽  
Ning Lei ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Precipitation Method ◽  
Hydroxyapatite Nanoparticles ◽  
Uniform Size ◽  
Gelatin Matrix ◽  
In Situ Deposition

Spherical hydroxyapatite nanoparticles with uniform size were homogeneously deposited in a gelatin matrix using an innovative in situ precipitation method.

Repurposing of antidepression drug sertraline for antimicrobial activity against Staphylococcus aureus: a potential approach for the treatment of osteomyelitis

2019 ◽  
Vol 43 (14) ◽  
pp. 5315-5324 ◽  
Author(s):  
D. Muthu ◽  
M. Gowri ◽  
G. Suresh Kumar ◽  
V. S. Kattimani ◽  
E. K. Girija
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Precipitation Method ◽  
Hydroxyapatite Nanoparticles ◽  
Potential Approach ◽  
Calcium Source

We report a potential approach to synthesize the repurposed sertraline drug-loaded hydroxyapatite nanoparticles using eggshell as the calcium source via the in situ precipitation method for the treatment of osteomyelitis.

In situ synthesis, characterization and in vitro studies of ciprofloxacin loaded hydroxyapatite nanoparticles for the treatment of osteomyelitis

2014 ◽  
Vol 2 (31) ◽  
pp. 5052-5060 ◽  
Author(s):  
G. Suresh Kumar ◽  
R. Govindan ◽  
E. K. Girija
Keyword(s):  
In Situ Synthesis ◽  
In Vitro Studies ◽  
Precipitation Method ◽  
Hydroxyapatite Nanoparticles

A series of ciprofloxacin loaded hydroxyapatite nanoparticles has been synthesized by anin situprecipitation method for osteomyelitis treatment.

In situ deposition of magnetic nanoparticles on glass mat using plasma sputtering method

2021 ◽  
pp. 1-11
Author(s):  
Sheila Shahidi ◽  
Sanaz Dalalsharifi ◽  
Mahmood Ghoranneviss ◽  
Rattanaphol Mongkholrattanasit
Keyword(s):  
Magnetic Nanoparticles ◽  
Plasma Sputtering ◽  
In Situ Deposition ◽  
Glass Mat

scholarly journals Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

2020 ◽  
Author(s):  
Isabel Pereira ◽  
José Eduardo Pereira ◽  
Luís Maltez ◽  
Alexandra Rodrigues ◽  
Catarina Rodrigues ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Substitute ◽  
Bone Substitutes ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Micro Computed Tomography ◽  
Synthetic Bone Substitute ◽  
In Situ Forming ◽  
Bioactive Agents ◽  
In Situ Forming Hydrogels

Abstract The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14 mm) for 3, 6 and 12 weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis.

scholarly journals Phase Transition and Coefficients of Thermal Expansion in Al2−xInxW3O12 (0.2 ≤ x ≤ 1)

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 4021
Author(s):  
Andrés Esteban Cerón Cerón Cortés ◽  
Anja Dosen ◽  
Victoria L. Blair ◽  
Michel B. Johnson ◽  
Mary Anne White ◽  
...  
Keyword(s):  
Phase Transition ◽  
Thermal Expansion ◽  
Thermal Shock ◽  
Monoclinic Phase ◽  
Ceramic Materials ◽  
Precipitation Method ◽  
Scanning Calorimetry ◽  
Orthorhombic Crystal ◽  
Co Precipitation

Materials from theA2M3O12 family are known for their extensive chemical versatility while preserving the polyhedral-corner-shared orthorhombic crystal system, as well as for their consequent unusual thermal expansion, varying from negative and near-zero to slightly positive. The rarest are near-zero thermal expansion materials, which are of paramount importance in thermal shock resistance applications. Ceramic materials with chemistry Al2−xInxW3O12 (x = 0.2–1.0) were synthesized using a modified reverse-strike co-precipitation method and prepared into solid specimens using traditional ceramic sintering. The resulting materials were characterized by X-ray powder diffraction (ambient and in situ high temperatures), differential scanning calorimetry and dilatometry to delineate thermal expansion, phase transitions and crystal structures. It was found that the x = 0.2 composition had the lowest thermal expansion, 1.88 × 10−6 K−1, which was still higher than the end member Al2W3O12 for the chemical series. Furthermore, the AlInW3O12 was monoclinic phase at room temperature and transformed to the orthorhombic form at ca. 200 °C, in contrast with previous reports. Interestingly, the x = 0.2, x = 0.4 and x = 0.7 materials did not exhibit the expected orthorhombic-to-monoclinic phase transition as observed for the other compositions, and hence did not follow the expected Vegard-like relationship associated with the electronegativity rule. Overall, compositions within the Al2−xInxW3O12 family should not be considered candidates for high thermal shock applications that would require near-zero thermal expansion properties.

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