In situ synthesis, characterization and in vitro studies of ciprofloxacin loaded hydroxyapatite nanoparticles for the treatment of osteomyelitis

2014 ◽  
Vol 2 (31) ◽  
pp. 5052-5060 ◽  
Author(s):  
G. Suresh Kumar ◽  
R. Govindan ◽  
E. K. Girija
Keyword(s):  
In Situ Synthesis ◽  
In Vitro Studies ◽  
Precipitation Method ◽  
Hydroxyapatite Nanoparticles

A series of ciprofloxacin loaded hydroxyapatite nanoparticles has been synthesized by anin situprecipitation method for osteomyelitis treatment.

scholarly journals Effect of Cavity Disinfectants on Adhesion to Primary Teeth—A Systematic Review

2021 ◽  
Vol 22 (9) ◽  
pp. 4398
Author(s):  
Ana Coelho ◽  
Inês Amaro ◽  
Ana Apolónio ◽  
Anabela Paula ◽  
José Saraiva ◽  
...  
Keyword(s):  
Primary Teeth ◽  
Clinical Success ◽  
Dental Materials ◽  
In Vitro Study ◽  
In Vitro Studies ◽  
Cochrane Library ◽  
Promising Alternative

Some authors have been proposing the use of cavity disinfectants in order to reduce, or even eliminate, the effect of the microorganisms present in a dental cavity before a restoration is placed. The aim of this study was to evaluate the effect of different cavity disinfectants on bond strength and clinical success of composite and glass ionomer restorations on primary teeth. The research was conducted using Cochrane Library, PubMed/MEDLINE, SCOPUS, and Web of Science for articles published up to February 2021. The search was performed according to the PICO strategy. The evaluation of the methodological quality of each in vitro study was assessed using the CONSORT checklist for reporting in vitro studies on dental materials. Sixteen in vitro studies and one in situ study fulfilled the inclusion criteria and were analyzed. Chlorhexidine was the most studied cavity disinfectant, and its use does not compromise dentin bonding. Sodium hypochlorite is a promising alternative, but more research on its use is required to clearly state that it can safely be used as a cavity disinfectant for primary teeth. Although other disinfectants were studied, there is a low-level evidence attesting their effects on adhesion, therefore their use should be avoided.

scholarly journals MICROSPECTROPHOTOMETRY OF NEWLY SYNTHESIZED STARCH IN SITU

1970 ◽  
Vol 18 (6) ◽  
pp. 439-449
Author(s):  
GEORGE E. WHEELER
Keyword(s):  
Absorption Maximum ◽  
In Vitro Studies ◽  
Phosphate Solution ◽  
Starch Digestion ◽  
Spectral Curves ◽  
Similarities And Differences

Many of the cells in stem sections of several Commelinaceae species synthesized much new starch when incubated in buffered 1% glucose 1-phosphate solution. The starch appeared in the cytoplasm rather than in the plastids. Although the starch I2-KI color was uniform within any one cell, there was considerable variation from cell to cell, even in the same section. The colors with I2-KI ranged from blue, through purples to magenta and mahogany. Tests with α-amylase and with β-amylase showed the starch to be amylose. Microspectrophotometrically determined extinction curves, based on the new starch in situ, varied with the visualized color. As expected, starch which stained blue with I2-KI had an absorption maximum in the orange-red wavelengths above 600 mµ; increasingly red I2-KI colors were characterized by shifts of the absorption maximum further into the shorter wavelengths. The course of new starch digestion by α-amylase and by β-amylase was followed visually and with the microspectrophotometer. Similarities and differences between these spectral curves and those published for in vitro studies are pointed out. The difficulties met with in using the microspectrophotometric method are discussed.

Repurposing of antidepression drug sertraline for antimicrobial activity against Staphylococcus aureus: a potential approach for the treatment of osteomyelitis

2019 ◽  
Vol 43 (14) ◽  
pp. 5315-5324 ◽  
Author(s):  
D. Muthu ◽  
M. Gowri ◽  
G. Suresh Kumar ◽  
V. S. Kattimani ◽  
E. K. Girija
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Precipitation Method ◽  
Hydroxyapatite Nanoparticles ◽  
Potential Approach ◽  
Calcium Source

We report a potential approach to synthesize the repurposed sertraline drug-loaded hydroxyapatite nanoparticles using eggshell as the calcium source via the in situ precipitation method for the treatment of osteomyelitis.

scholarly journals Adhesion of Hydroxyapatite Nanoparticles to Dental Materials under Oral Conditions

Scanning ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Cíntia Mirela Guimarães Nobre ◽  
Norbert Pütz ◽  
Matthias Hannig
Keyword(s):  
Electron Microscopy ◽  
Dental Materials ◽  
Hydroxyapatite Nanoparticles ◽  
Pellicle Formation ◽  
Transmission Electron ◽  
Different Shapes ◽  
Oral Conditions ◽  
Dental Applications

Hydroxyapatite nanoparticles (nano-HAP) are receiving considerable attention for dental applications, and their adhesion to enamel is well established. However, there are no reports concerning the effects of HAP on other dental materials, and most of the studies in this field are based on in vitro designs, neglecting the salivary pellicle-apatite interactions. Thus, this in situ pilot study aims to evaluate the effects of three hydroxyapatite-based solutions and their interactions with different dental material surfaces under oral conditions. Hence, two volunteers carried intraoral splints with mounted samples from enamel and from three dental materials: titanium, ceramics, and polymethyl-methacrylate (PMMA). Three HAP watery solutions (5%) were prepared with different shapes and sizes of nano-HAP (HAP I, HAP II, HAP III). After 3 min of pellicle formation, 10 ml rinse was performed during 30 sec. Rinsing with water served as control. Samples were accessed immediately after rinsing, 30 min and 2 h after rinsing. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to characterize the particles, and SEM evaluated the pellicle-HAP interactions. SEM and TEM results showed a high variation in the size range of the particles applied. A heterogeneous HAP layer was present after 2 h on enamel, titanium, ceramics, and PMMA surfaces under oral conditions. Bridge-like structures were visible between the nano-HAP and the pellicle formed on enamel, titanium, and PMMA surfaces. In conclusion, nano-HAP can adhere not only to enamel but also to artificial dental surfaces under oral conditions. The experiment showed that the acquired pellicle act as a bridge between the nano-HAP and the materials’ surface.

PEG-Iron Oxide Core-Shell Nanoparticles: In situ Synthesis and In vitro Biocompatibility Evaluation for Potential T2-MRI Applications

2020 ◽  
Vol 10 (4) ◽  
pp. 1107-1120
Author(s):  
Karina Almeida Barcelos ◽  
Marli Luiza Tebaldi ◽  
Eryvaldo Socrates Tabosa do Egito ◽  
Nádia Miriceia Leão ◽  
Daniel Cristian Ferreira Soares
Keyword(s):  
Iron Oxide ◽  
In Situ Synthesis ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
In Vitro Biocompatibility ◽  
Iron Oxide Core ◽  
Core Shell Nanoparticles ◽  
T2 Mri

Microwave assisted-in situ synthesis of porous titanium/calcium phosphate composites and their in vitro apatite-forming capability

2015 ◽  
Vol 83 ◽  
pp. 50-57 ◽  
Author(s):  
Man-Tik Choy ◽  
Chak-Yin Tang ◽  
Ling Chen ◽  
Wing-Cheung Law ◽  
Chi-Pong Tsui ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Porous Titanium ◽  
In Situ Synthesis ◽  
Microwave Assisted

In situ synthesis of NIR-light emitting carbon dots derived from spinach for bio-imaging applications

2017 ◽  
Vol 5 (35) ◽  
pp. 7328-7334 ◽  
Author(s):  
Liping Li ◽  
Ruiping Zhang ◽  
Chunxiang Lu ◽  
Jinghua Sun ◽  
Lingjie Wang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Carbon Dots ◽  
In Situ Synthesis ◽  
Light Emitting ◽  
Nir Light ◽  
Bio Imaging ◽  
One Step

NIR-light emitting CDs (R-CDs) were prepared using spinach as a precursor by one-step solvothermal treatment. The R-CDs exhibited great optical properties, negligible toxicity, and superior labelling capability both in vitro and in vivo.

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