Hydrogel composite scaffolds with an attenuated immunogenicity component for bone tissue engineering applications

2021 ◽  
Author(s):  
Chenyuan Gao ◽  
Wan Ting Sow ◽  
Yingying Wang ◽  
Yili Wang ◽  
Dejun Yang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Composite Scaffolds ◽  
Engineering Applications ◽  
Hydrogel Composite

Xenogeneic bones are potential templates for bone regeneration.

Clinoptilolite/PCL–PEG–PCL composite scaffolds for bone tissue engineering applications

2016 ◽  
Vol 31 (8) ◽  
pp. 1148-1168 ◽  
Author(s):  
Engin Pazarçeviren ◽  
Özge Erdemli ◽  
Dilek Keskin ◽  
Ayşen Tezcaner
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffolds ◽  
Engineering Applications

scholarly journals Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2040 ◽  
Author(s):  
Hui Xie ◽  
Zhenxing Wang ◽  
Liming Zhang ◽  
Qian Lei ◽  
Aiqi Zhao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Umbilical Vein ◽  
Composite Graft ◽  
Electron Microscopic ◽  
Engineering Applications

One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted method of achieving this goal. Recently, the proangiogenic potential of mesenchymal stem cell-derived microvesicles (MSC-MVs) has been confirmed in several studies. In the present study, we incorporated MSC-MVs into alginate-polycaprolactone (PCL) constructs that had previously been developed for bone tissue engineering applications, with the aim of promoting angiogenesis and bone regeneration. MSC-MVs were first isolated from the supernatant of rat bone marrow-derived MSCs and characterized by scanning electron microscopic, confocal microscopic, and flow cytometric analyses. The proangiogenic potential of MSC-MVs was demonstrated by the stimulation of tube formation of human umbilical vein endothelial cellsin vitro. MSC-MVs and osteodifferentiated MSCs were then encapsulated with alginate and seeded onto porous three-dimensional printed PCL scaffolds. When combined with osteodifferentiated MSCs, the MV-alginate-PCL constructs enhanced vessel formation and tissue-engineered bone regeneration in a nude mouse subcutaneous bone formation model, as demonstrated by micro-computed tomographic, histological, and immunohistochemical analyses. This MV-alginate-PCL construct may offer a novel, proangiogenic, and cost-effective option for bone tissue engineering.

Novel chitin/nanosilica composite scaffolds for bone tissue engineering applications

2009 ◽  
Vol 45 (3) ◽  
pp. 289-292 ◽  
Author(s):  
K. Madhumathi ◽  
P.T. Sudheesh Kumar ◽  
K.C. Kavya ◽  
T. Furuike ◽  
H. Tamura ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffolds ◽  
Engineering Applications
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