Tumor pH-triggered “charge conversion” nanocarriers with on-demand drug release for precise cancer therapy

2020 ◽  
Vol 8 (40) ◽  
pp. 9351-9361
Author(s):  
Bo-Ai Ma ◽  
Chun-Yang Sun
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Drug Release ◽  
X Ray ◽  
On Demand ◽  
Tumor Ph

The pHe-triggered “charge conversion” nanocarriers were developed for combined X-ray-induced photodynamic therapy (X-PDT) and hypoxia-activated chemotherapy.

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

Binary Dimeric Prodrug Nanoparticles for Self-Boosted Drug Release and Synergistic Chemo-Photodynamic Therapy

2022 ◽  
Author(s):  
Youwei Zhang ◽  
Qing Pei ◽  
Ying Yue ◽  
Zhigang Xie
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Drug Release ◽  
Clinical Performance ◽  
Therapeutic Efficiency ◽  
Normal Tissues ◽  
Carrier Free

Chemotherapy is the major strategy for cancer therapy, but its limited therapeutic efficiency and serious toxicity to normal tissues greatly restrict its clinical performance. Herein, we develop carrier-free self-activated prodrug...

scholarly journals Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

Nano Research ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Yongjuan Li ◽  
Jian Hu ◽  
Xun Liu ◽  
Yong Liu ◽  
Shixian Lv ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
On Demand ◽  
Anti Cancer

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

2020 ◽  
Vol 27 (23) ◽  
pp. 3877-3887
Author(s):  
Xinyu He ◽  
Xianzhu Yang ◽  
Dongdong Li ◽  
Ziyang Cao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Uptake ◽  
Design Strategies ◽  
Polymeric Nanocarriers ◽  
Normal Tissues ◽  
On Demand ◽  
Nir Light

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

Zwitterionic Polysulfamide Drug Nanogels with Microwave Augmented Tumor Accumulation and On‐Demand Drug Release for Enhanced Cancer Therapy

2020 ◽  
Vol 30 (23) ◽  
pp. 2001832 ◽  
Author(s):  
Shaojun Peng ◽  
Hao Wang ◽  
Wei Zhao ◽  
Yongjie Xin ◽  
Yu Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
On Demand ◽  
Tumor Accumulation

scholarly journals LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors

2017 ◽  
Vol 4 (6) ◽  
pp. 1092-1101 ◽  
Author(s):  
Hongmin Chen ◽  
Xilin Sun ◽  
Geoffrey D. Wang ◽  
Koichi Nagata ◽  
Zhonglin Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Near Infrared ◽  
X Ray ◽  
Theranostic Nanoparticles ◽  
Theranostic Agents

LiGa5O8:Cr nanoparticles mediate near-infrared X-ray luminescence and X-ray induced photodynamic therapy, making them attractive theranostic agents for cancer therapy.

Comb-like poly(l-cysteine) derivatives with different side groups: synthesis via photochemistry and click chemistry, multi-responsive nanostructures, triggered drug release and cytotoxicity

2015 ◽  
Vol 6 (38) ◽  
pp. 6857-6869 ◽  
Author(s):  
Xingjie Wu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Click Chemistry ◽  
On Demand ◽  
Triggered Drug Release ◽  
Ene Addition

A series of comb-like graft polypeptides having different side groups and tunable grafting ratios were prepared by sequential photocleavage reactions and Michael-type thiol–ene addition, which provides a promising platform for on-demand nanomedicine and cancer therapy.

NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity

2015 ◽  
Vol 6 (21) ◽  
pp. 4030-4039 ◽  
Author(s):  
Gang Liu ◽  
Na Liu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Composite Nanoparticles ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand ◽  
Triggered Drug Release

Near infrared light-responsive polypeptide copolymer upconversion composite nanoparticles exhibited controllable drug release and triggered cytotoxicity useful for on-demand drug delivery and cancer therapy.

ROS‐Responsive Camptothecin Prodrug Nanoparticles for On‐Demand Drug Release and Combination of Chemotherapy and Photodynamic Therapy

2020 ◽  
Vol 30 (52) ◽  
pp. 2005918
Author(s):  
Bingyang Chu ◽  
Ying Qu ◽  
Xinlong He ◽  
Ying Hao ◽  
Chengli Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
On Demand
Sign in / Sign up

Export Citation Format

Share Document