scholarly journals Polymer composition primarily determines the protein recognition characteristics of molecularly imprinted hydrogels

2020 ◽  
Vol 8 (34) ◽  
pp. 7685-7695
Author(s):  
Abhijeet K. Venkataraman ◽  
John R. Clegg ◽  
Nicholas A. Peppas
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Material Composition ◽  
Polymer Composition ◽  
Protein Recognition ◽  
Molecularly Imprinted

A hydrogel's molecular recognition properties are determined by the material composition, and are minimally influenced by molecular imprinting.

Supercritical CO2-assisted synthesis of an ultrasensitive amphibious quantum dot-molecularly imprinted sensor

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 63338-63341 ◽  
Author(s):  
A. Lourenço ◽  
R. Viveiros ◽  
A. Mouro ◽  
J. C. Lima ◽  
V. D. B. Bonifácio ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Molecular Recognition ◽  
Quantum Dot ◽  
Bisphenol A ◽  
Molecular Imprinting ◽  
Supercritical Co2 ◽  
Molecularly Imprinted ◽  
Low Concentrations

A green supercritical CO2-assisted molecular imprinting protocol enabled the production of smart sensory particles, incorporating quantum dots, with molecular recognition to bisphenol A at very low concentrations (4 nM).

Inhibitor-assisted synthesis of molecularly imprinted microbeads for protein recognition

2018 ◽  
Vol 10 (9) ◽  
pp. 997-1005 ◽  
Author(s):  
Hasan Basan ◽  
Mehmet Dinc ◽  
Boris Mizaikoff
Keyword(s):  
Synergistic Effect ◽  
Molecular Imprinting ◽  
Protein Recognition ◽  
Surface Molecular Imprinting ◽  
Molecularly Imprinted

Synergistic effect of inhibitor assisted affinity and surface molecular imprinting strategy on pepsin imprinting.

Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

2020 ◽  
Vol 8 (35) ◽  
pp. 7987-7993
Author(s):  
Tetsuro Saeki ◽  
Eri Takano ◽  
Hirobumi Sunayama ◽  
Yuri Kamon ◽  
Ryo Horikawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Recognition ◽  
Functional Groups ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Cancer Biomarker ◽  
Glycoprotein P ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

Discovery and Development of OMNiMIPs: One MoNomer Molecularly Imprinted Polymers

2007 ◽  
Vol 1005 ◽  
Author(s):  
David A. Spivak ◽  
Martha Sibrian-Vazquez ◽  
Stephen Houck
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Functional Monomer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Element ◽  
Molecular Recognition Element ◽  
New Formulation ◽  
Separation Media

AbstractThere is enormous potential for the analytical applications of molecularly imprinted polymers (MIPs); for example, the imprinted polymer sites can function as the molecular recognition element of sensors, immunoassays, and separation media. However, difficulties with formulation variables and the need for empirical optimization have inhibited the widespread use of MIPs by the general scientific community. While investigating new crosslinkers for molecular imprinting, we have recently discovered a much simpler approach to MIP formation which utilizes a single crosslinking monomer, NOBE (N, Obismethacryloyl ethanolamine) in addition to template, solvent and initiator (shown in Scheme 1). We have given this molecular imprinting method the acronym “OMNiMIPs” which stands for one monomer molecularly imprinted polymers. This new formulation eliminates variables such as choice of functional monomer (FM) and crosslinker (XL), the ratio of functional monomer to crosslinker (FM/XL), and the ratio of functional monomer to template which normally complicates MIP design. The affects of OMNiMIP performance variables toward molecular recognition indicate significant differences between these new materials and traditional MIPs formulated with ethyleneglycol dimethacrylate (EGDMA) and methacrylic acid (MAA). These differences and the utility of OMNiMIPs will be discussed.

scholarly journals Molecular Recognition: Perspective and a New Approach

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2757
Author(s):  
W. Rudolf Seitz ◽  
Casey J. Grenier ◽  
John R. Csoros ◽  
Rongfang Yang ◽  
Tianyu Ren
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Binding Kinetics ◽  
Molecularly Imprinted ◽  
New Approach ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Water Blocking ◽  
High Level

This perspective presents an overview of approaches to the preparation of molecular recognition agents for chemical sensing. These approaches include chemical synthesis, using catalysts from biological systems, partitioning, aptamers, antibodies and molecularly imprinted polymers. The latter three approaches are general in that they can be applied with a large number of analytes, both proteins and smaller molecules like drugs and hormones. Aptamers and antibodies bind analytes rapidly while molecularly imprinted polymers bind much more slowly. Most molecularly imprinted polymers, formed by polymerizing in the presence of a template, contain a high level of covalent crosslinker that causes the polymer to form a separate phase. This results in a material that is rigid with low affinity for analyte and slow binding kinetics. Our approach to templating is to use predominantly or exclusively noncovalent crosslinks. This results in soluble templated polymers that bind analyte rapidly with high affinity. The biggest challenge of this approach is that the chains are tangled when the templated polymer is dissolved in water, blocking access to binding sites.

Molecularly imprinted nanozymes with faster catalytic activity and better specificity

Nanoscale ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 4854-4863 ◽  
Author(s):  
Zijie Zhang ◽  
Yuqing Li ◽  
Xiaohan Zhang ◽  
Juewen Liu
Keyword(s):  
Activation Energy ◽  
Catalytic Activity ◽  
Molecular Imprinting ◽  
Selective Adsorption ◽  
Molecularly Imprinted ◽  
Product Release

Molecular imprinting accelerates nanozyme catalysis and improves specificity attributable to selective adsorption of imprinted substrate, decreasing activation energy and facilitating product release.

Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase

2006 ◽  
Vol 571 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Xiangjun Liu ◽  
Canbin Ouyang ◽  
Rui Zhao ◽  
Dihua Shangguan ◽  
Yi Chen ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymer ◽  
Mobile Phase ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Molecular imprinting of proteins emerging as a tool for protein recognition

2008 ◽  
Vol 6 (14) ◽  
pp. 2459 ◽  
Author(s):  
Toshifumi Takeuchi ◽  
Takayuki Hishiya
Keyword(s):  
Molecular Imprinting ◽  
Protein Recognition

Molecularly imprinted fluorescent and colorimetric sensor based on TiO2@Cu(OH)2 nanoparticle autocatalysis for protein recognition

2013 ◽  
Vol 1 (9) ◽  
pp. 1256 ◽  
Author(s):  
Yanxia Li ◽  
Yujun Li ◽  
Lihua Huang ◽  
Qiu Bin ◽  
Zhenyu Lin ◽  
...  
Keyword(s):  
Colorimetric Sensor ◽  
Protein Recognition ◽  
Molecularly Imprinted
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