Engineered macroporous hydrogel scaffolds via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration

2020 ◽  
Vol 8 (28) ◽  
pp. 6100-6114
Author(s):  
Haotian Pan ◽  
Huichang Gao ◽  
Qingtao Li ◽  
Zefeng Lin ◽  
Qi Feng ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Composite Hydrogel ◽  
Pickering Emulsions ◽  
Mgo Nanoparticles ◽  
Hydrogel Scaffolds

A novel macroporous composite hydrogel scaffolds were developed by using Pickering emulsions stabilized by MgO NPs for application in the field of bone regeneration.

Engineering 3D-printed core-shell hydrogel scaffolds reinforced with hybrid hydroxyapatite/polycaprolactone nanoparticles for in vivo bone regeneration

2021 ◽  
Author(s):  
Salma Essam El-Habashy ◽  
Amal ElKamel ◽  
Marwa Essawy ◽  
Elsayeda-Zeinab Abdelfattah ◽  
Hoda M Eltaher
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Composite Hydrogel ◽  
Core Shell ◽  
Hydrogel Scaffolds ◽  
3D Printed ◽  
Indispensable Tool

The versatility of 3D printing has rendered it an indispensable tool for the fabrication of composite hydrogel scaffolds, offering bone biomimetic features through inorganic and biopolymeric components as promising platforms...

Tobacco Mosaic Virus Functionalized Alginate Hydrogel Scaffolds for Bone Regeneration in Rats with Cranial Defect

2016 ◽  
Vol 2 (4) ◽  
pp. 606-615 ◽  
Author(s):  
Jittima Amie Luckanagul ◽  
Kamolrat Metavarayuth ◽  
Sheng Feng ◽  
Phudit Maneesaay ◽  
Amy Y. Clark ◽  
...  
Keyword(s):  
Tobacco Mosaic Virus ◽  
Bone Regeneration ◽  
Mosaic Virus ◽  
Alginate Hydrogel ◽  
Hydrogel Scaffolds ◽  
Cranial Defect

scholarly journals Injectable Alginate-Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 497 ◽  
Author(s):  
Moumita Ghosh ◽  
Michal Halperin-Sternfeld ◽  
Itzhak Grinberg ◽  
Lihi Adler-Abramovich
Keyword(s):  
Extracellular Matrix ◽  
Bone Regeneration ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Composite Hydrogel ◽  
Bone Tissue Regeneration ◽  
Pcr Analysis ◽  
Alizarin Red ◽  
In Vitro Biocompatibility

The high demand for tissue engineering scaffolds capable of inducing bone regeneration using minimally invasive techniques prompts the need for the development of new biomaterials. Herein, we investigate the ability of Alginate incorporated with the fluorenylmethoxycarbonyl-diphenylalanine (FmocFF) peptide composite hydrogel to serve as a potential biomaterial for bone regeneration. We demonstrate that the incorporation of the self-assembling peptide, FmocFF, in sodium alginate leads to the production of a rigid, yet injectable, hydrogel without the addition of cross-linking agents. Scanning electron microscopy reveals a nanofibrous structure which mimics the natural bone extracellular matrix. The formed composite hydrogel exhibits thixotropic behavior and a high storage modulus of approximately 10 kPA, as observed in rheological measurements. The in vitro biocompatibility tests carried out with MC3T3-E1 preosteoblast cells demonstrate good cell viability and adhesion to the hydrogel fibers. This composite scaffold can induce osteogenic differentiation and facilitate calcium mineralization, as shown by Alizarin red staining, alkaline phosphatase activity and RT-PCR analysis. The high biocompatibility, excellent mechanical properties and similarity to the native extracellular matrix suggest the utilization of this hydrogel as a temporary three-dimensional cellular microenvironment promoting bone regeneration.

A bioinspired mineral-organic composite hydrogel as a self-healable and mechanically robust bone graft for promoting bone regeneration

2020 ◽  
pp. 127512
Author(s):  
Shumeng Bai ◽  
Mengya Zhang ◽  
Xiaowei Huang ◽  
Xueliang Zhang ◽  
Chunhua Lu ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Composite Hydrogel

scholarly journals Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects

2021 ◽  
Vol 8 ◽  
Author(s):  
Bin Zhao ◽  
Jingya He ◽  
Feng Wang ◽  
Ruxiao Xing ◽  
Bin Sun ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Survival ◽  
Bone Regeneration ◽  
Sodium Alginate ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Bone Repair ◽  
Composite Hydrogel ◽  
Alginate Hydrogel ◽  
Hypoxic Environment

Oxygen is essential for cell survival and tissue regeneration. Scaffolds releasing oxygen have been hypothesized as an ideal strategy for bone repair. However, excessive oxygen supply will disturb the redox balance, lead to oxidative stress, and affect bone regeneration. In this study, we synthesized a hydrogel from sodium alginate and loaded it calcium peroxide nanoparticles as an oxygen generating material and vitamin C as a pH regulator and antioxidant. The composite hydrogel, with a pH value close to physiological humoral fluid, could release oxygen to alleviate hypoxia in the bone defect and reduce the side effects of excessive hydrogen peroxide. In in vitro experiments, the composite hydrogel promoted the osteogenic differentiation and ALP and mineralization ability of rat bone marrow mesenchymal stem cells in a hypoxic environment (2% O2). In animal experiments, the composite hydrogel was applied in rat skull defect models. It promoted the healing of bone defects. These results suggest that sodium alginate hydrogel releasing oxygen and vitamin C is suitable for cell survival and tissue regeneration in a hypoxic environment and has good application prospects in bone defect repair.

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