scholarly journals Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections

2020 ◽  
Vol 8 (41) ◽  
pp. 9466-9480
Author(s):  
Dan Li ◽  
Beena Kumari ◽  
Jessa Marie Makabenta ◽  
Bailong Tao ◽  
Kun Qian ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Economic Loss ◽  
Resistant Bacteria ◽  
Metal Nanoclusters ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Coinage Metal ◽  
The Past

Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades.

scholarly journals Prophylactic Administration of a Bacteriophage Cocktail Is Safe and Effective in Reducing Salmonella enterica Serovar Typhimurium Burden in Vivo

2021 ◽  
Author(s):  
Quentin Lamy-Besnier ◽  
Lorenzo Chaffringeon ◽  
Marta Lourenço ◽  
Rayford B. Payne ◽  
Jimmy T. Trinh ◽  
...  
Keyword(s):  
Side Effects ◽  
Bacterial Infections ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Economic Loss ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Serovar Typhimurium ◽  
Selection Of

Foodborne bacterial infections cause worldwide economic loss. During an epidemic, the use of antibiotics to slow down the spread of the disease is not recommended because of their side effects on the resident microbiota and the selection of antibiotic-resistant bacteria.

scholarly journals The Unrecognized Threat of Secondary Bacterial Infections with COVID-19

mBio ◽  
2020 ◽  
Vol 11 (4) ◽  
Author(s):  
Mylene Vaillancourt ◽  
Peter Jorth
Keyword(s):  
Bacterial Infections ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Factors Associated ◽  
The Past ◽  
Intensive Use ◽  
Great Health ◽  
Secondary Bacterial Pneumonia

ABSTRACT Coronavirus disease 2019 (COVID-19) is the greatest pandemic of our generation, with 16 million people affected and 650,000 deaths worldwide so far. One of the risk factors associated with COVID-19 is secondary bacterial pneumonia. In recent studies on COVID-19 patients, secondary bacterial infections were significantly associated with worse outcomes and death despite antimicrobial therapies. In the past, the intensive use of antibiotics during the severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic led to increases in the prevalence of multidrug-resistant bacteria. The rising number of antibiotic-resistant bacteria and our decreasing capacity to eradicate them not only render us more vulnerable to bacterial infections but also weaken us during viral pandemics. The COVID-19 pandemic reminds us of the great health challenges we are facing, especially regarding antibiotic-resistant bacteria.

scholarly journals Antibiotic-Resistant Bacteria in Clams—A Study on Mussels in the River Rhine

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 571
Author(s):  
Nicole Zacharias ◽  
Iris Löckener ◽  
Sarah M. Essert ◽  
Esther Sib ◽  
Gabriele Bierbaum ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Sewage Treatment ◽  
Sewage Treatment Plant ◽  
Treatment Plant ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
River Rhine ◽  
Antibiotic Resistant Bacteria ◽  
Surrounding Water ◽  
Antibiotic Resistant

Bacterial infections have been treated effectively by antibiotics since the discovery of penicillin in 1928. A worldwide increase in the use of antibiotics led to the emergence of antibiotic resistant strains in almost all bacterial pathogens, which complicates the treatment of infectious diseases. Antibiotic-resistant bacteria play an important role in increasing the risk associated with the usage of surface waters (e.g., irrigation, recreation) and the spread of the resistance genes. Many studies show that important pathogenic antibiotic-resistant bacteria can enter the environment by the discharge of sewage treatment plants and combined sewage overflow events. Mussels have successfully been used as bio-indicators of heavy metals, chemicals and parasites; they may also be efficient bio-indicators for viruses and bacteria. In this study an influence of the discharge of a sewage treatment plant could be shown in regard to the presence of E. coli in higher concentrations in the mussels downstream the treatment plant. Antibiotic-resistant bacteria, resistant against one or two classes of antibiotics and relevance for human health could be detected in the mussels at different sampling sites of the river Rhine. No multidrug-resistant bacteria could be isolated from the mussels, although they were found in samples of the surrounding water body.

Targetable nano-delivery vehicles to deliver anti-bacterial small acid-soluble spore protein (SASP) genes

2021 ◽  
Author(s):  
Anne M. L. Barnard ◽  
James A. Cass
Keyword(s):  
Bacterial Infections ◽  
Treatment Options ◽  
Resistant Bacteria ◽  
Wild Type ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Specific Target ◽  
Delivery Vehicles ◽  
New Treatment

Interest in phage-based therapeutics is increasing, at least in part due to the need for new treatment options for infections caused by antibiotic-resistant bacteria. It is possible to use wild-type (WT) phages to treat bacterial infections, but it is also possible to modify WT phages to generate therapeutics with improved features. Here, we will discuss features of Phico Therapeutics’ SASPject technology, which modifies phages for use as targetable nano-delivery vehicles (NDV), to introduce antibacterial Small Acid Soluble Spore Protein (SASP) genes into specific target bacteria.

scholarly journals Antibiotic Resistance in Oral/Respiratory Bacteria

1998 ◽  
Vol 9 (4) ◽  
pp. 522-540 ◽  
Author(s):  
M.C. Roberts
Keyword(s):  
Antibiotic Resistance ◽  
Mercury Resistance ◽  
Resistant Bacteria ◽  
Antibiotic Residues ◽  
Mechanisms Of Resistance ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
The Past ◽  
Resistant Gene ◽  
Rapid Transport

In the last 20 years, changes in world technology have occurred which have allowed for the rapid transport of people, food, and goods. Unfortunately, antibiotic residues and antibiotic-resistant bacteria have been transported as well. Over the past 20 years, the rise in antibiotic-resistant gene carriage in virtually every species of bacteria, not just oral/respiratory bacteria, has been documented. In this review, the main mechanisms of resistance to the important antibiotics used for treatment of disease caused by oral/respiratory bacteria-including β-lactams, tetracycline, and metronidazole-are discussed in detail. Mechanisms of resistance for macrolides, lincosamides, streptogramins, trimethoprim, sulfonamides, aminoglycosides, and chloramphenicol are also discussed, along with the possible role that mercury resistance may play in the bacterial ecology.

Water-soluble branched polymer for combined chemo-immunotherapy of bacterial infections

2021 ◽  
Author(s):  
Xiaomei Dai ◽  
Lele Yang ◽  
Qingqing Xu ◽  
Jifang Ma ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Public Health ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Water Soluble ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Public Health Challenges ◽  
Significant Public Health ◽  
Therapeutic Alternatives

Bacterial infection is one of the most significant public health challenges due to the limited choices of antibiotics which can overcome antibiotic-resistant bacteria. The promising nonantibiotic therapeutic alternatives for antibiotic-resistant...

Phage Therapy: A Potential Solution for Antibiotic Resistance

2021 ◽  
Author(s):  
Chirag Choudhary ◽  
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Biological Agents ◽  
Resistant Bacteria ◽  
Potential Solution ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
The Future

The idea of using a virus to kill bacteria may seem counterintuitive, but it may be the future of treating bacterial infections. Before the COVID-19 pandemic, one of the most frightening biological agents were so-called “superbugs” – antibiotic resistant bacteria – which could not be treated with conventional therapeutics. When antibiotics were first developed, they were hailed as a panacea. A panacea they were not.

scholarly journals Editorial for the Special Issue: “Phage Therapy: A Biological Approach to Treatment of Bacterial Infections”

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 721
Author(s):  
Saija Kiljunen
Keyword(s):  
Healthcare Costs ◽  
Bacterial Infections ◽  
Phage Therapy ◽  
Resistant Bacteria ◽  
Special Issue ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Biological Approach

The emergence of antibiotic-resistant bacteria presents a major challenge in terms of increased morbidity, mortality, and healthcare costs [...]

scholarly journals Computational Model To Quantify the Growth of Antibiotic-Resistant Bacteria in Wastewater

mSystems ◽  
2021 ◽  
Author(s):  
Indorica Sutradhar ◽  
Carly Ching ◽  
Darash Desai ◽  
Mark Suprenant ◽  
Emma Briars ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Computational Model ◽  
Bacterial Infections ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Antibiotic Resistant Bacteria ◽  
Bacterial Populations ◽  
Antibiotic Resistant ◽  
The World ◽  
Wealth Of Nations

The rate at which antimicrobial resistance (AMR) has developed and spread throughout the world has increased in recent years, and according to the Review on Antimicrobial Resistance in 2014, it is suggested that the current rate will lead to AMR-related deaths of several million people by 2050 (Review on Antimicrobial Resistance, Tackling a Crisis for the Health and Wealth of Nations , 2014). One major reservoir of resistant bacterial populations that has been linked to outbreaks of drug-resistant bacterial infections but is not well understood is in wastewater settings, where antibiotic pollution is often present.

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