scholarly journals Chiral molecules on curved colloidal membranes

Soft Matter ◽  
2020 ◽  
Vol 16 (45) ◽  
pp. 10310-10319
Author(s):  
Sk Ashif Akram ◽  
Arabinda Behera ◽  
Prerna Sharma ◽  
Anirban Sain
Keyword(s):  
Chiral Molecules ◽  
Aspect Ratios ◽  
Colloidal Membranes

Nematic arrangement on catenoids of different aspect ratios.

Tire Treadwear — A Comprehensive Evaluation of the Factors: Generic Type, Aspect Ratio, Tread Pattern, and Tread Composition Part III: Results of Supplementary and UTQG Treadwear Test Series

1986 ◽  
Vol 14 (4) ◽  
pp. 235-263
Author(s):  
A. G. Veith
Keyword(s):  
Carbon Black ◽  
Comprehensive Evaluation ◽  
Work Intensity ◽  
Generic Type ◽  
Aspect Ratios ◽  
Index Variation ◽  
Primary Determinant ◽  
Severity Levels ◽  
High Test ◽  
Better Than

Abstract The effect of tread compound variation on tire treadwear was studied using bias and radial tires of two aspect ratios. Compound variations included types of rubber and carbon black as well as the levels of carbon black, process oil, and curatives. At low to moderate test severity, SBR and an SBR/BR blend performed better than NR while at high test severity NR and SBR were better than the SBR/BR blend. The SBR/BR blend was the best at low severity testing. Higher structure and higher surface area carbon black gave improved treadwear at all severity levels. The concept of a “frictional work intensity” as the primary determinant of treadwear index variation with test severity is proposed. Some factors which influence frictional work intensity are discussed.

Metal-, and Organocatalyst-Free One-Pot Assembly of Chiral Aza-Tricyclic Molecules: Creating Six Contiguous Stereocenters from 2-D-Structures and an Amino Acid

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Amino Acid ◽  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Catalyst ◽  
Chiral Complex ◽  
Free Process

<p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> Practically, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for desired reactions. As a result, developing a method that enables rapid assembly of chiral complex molecules under metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward route to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“subcatalyst”) dual role of the intermediate enhances </a><a>the coordinational proximity of the chiral substrate and catalyst</a> in the key Aza-Michael/Michael cascade resulting in a substantial steric discrimination and an excellent overall diastereoselectivity. Whereas the “subcatalyst” (hidden catalyst) is not present in the reaction’s initial components, which renders a chiral catalyst-free process, it is strategically produced to promote sequential self-catalyzed reactions. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules and aid for the quest to create next generation of therapeutic agents.</p>

Advanced Fringe Analysis Techniques in Circuit Edit

2006 ◽  
Author(s):  
R.K. Jain ◽  
T. Malik ◽  
T.R. Lundquist ◽  
C.-C. Tsao ◽  
W.J. Walecki
Keyword(s):  
Imaging System ◽  
Success Rates ◽  
Endpoint Detection ◽  
Fringe Analysis ◽  
Analysis Techniques ◽  
Aspect Ratios ◽  
Slope Correction ◽  
Trench Area ◽  
And Control ◽  
Thickness Measurements

Abstract Novel Fabry Perot [1] fringe analysis techniques for monitoring the etching process with a coaxial photon-ion column [2] in the Credence OptiFIB are reported. Presently the primary application of these techniques in circuit edit is in trenching either from the front side or from the backside of a device. Optical fringes are observed in reflection geometry through the imaging system when the trench floor is thin and semi-transparent. The observed fringes result from optical interference in the etalon formed between the trench floor (Si in the case of backside trenching) and the circuitry layer beyond the trench floor. In-situ real-time thickness measurements and slope correction techniques are proposed that improve endpoint detection and control planarity of the trench floor. For successful through silicon edits, reliable endpoint detection and co-planarity of a local trench is important. Reliable endpoint detection prevents milling through bulk silicon and damaging active circuitry. Uneven trench floor thickness results in premature endpoint detection with sufficient thickness remaining in only part of the trench area. Good co-planarity of the trench floor also minimizes variability in the aspect ratios of the edit holes, hence increasing success rates in circuit edit.

Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments

2019 ◽  
Vol 15 (1) ◽  
pp. 102-118 ◽  
Author(s):  
Carolina Campos-Rodríguez ◽  
José G. Trujillo-Ferrara ◽  
Ameyali Alvarez-Guerra ◽  
Irán M. Cumbres Vargas ◽  
Roberto I. Cuevas-Hernández ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
In Silico ◽  
Biological Properties ◽  
Chiral Molecules ◽  
Chiral Compounds ◽  
Plus Maze ◽  
In Silico Studies ◽  
The Central Nervous System

Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative- hypnotic and antiepileptic effects on the central nervous system. N-substituted phthalimides have an interesting chemical structure that confers important biological properties. Objective: Non-chiral (ortho and para bis-isoindoline-1,3-dione, phthaloylglycine) and chiral phthalimides (N-substituted with aspartate or glutamate) were synthesized and the sedative, anxiolytic and anticonvulsant effects were tested. Method: Homology modeling and molecular docking were employed to predict recognition of the analogues by hNMDA and mGlu receptors. The neuropharmacological activity was tested with the open field test and elevated plus maze (EPM). The compounds were tested in mouse models of acute convulsions induced either by pentylenetetrazol (PTZ; 90 mg/kg) or 4-aminopyridine (4-AP; 10 mg/kg). Results: The ortho and para non-chiral compounds at 562.3 and 316 mg/kg, respectively, decreased locomotor activity. Contrarily, the chiral compounds produced excitatory effects. Increased locomotor activity was found with S-TGLU and R-TGLU at 100, 316 and 562.3 mg/kg, and S-TASP at 316 and 562.3 mg/kg. These molecules showed no activity in the EPM test or PTZ model. In the 4-AP model, however, S-TGLU (237.1, 316 and 421.7 mg/kg) as well as S-TASP and R-TASP (316 mg/kg) lowered the convulsive and death rate. Conclusion: The chiral compounds exhibited a non-competitive NMDAR antagonist profile and the non-chiral molecules possessed selective sedative properties. The NMDAR exhibited stereoselectivity for S-TGLU while it is not a preference for the aspartic derivatives. The results appear to be supported by the in silico studies, which evidenced a high affinity of phthalimides for the hNMDAR and mGluR type 1.

scholarly journals Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 412
Author(s):  
Kaan Erdem ◽  
Vahid Ebrahimpour Ahmadi ◽  
Ali Kosar ◽  
Lütfullah Kuddusi
Keyword(s):  
Cell Sorting ◽  
Microfluidic Channel ◽  
Major Axis ◽  
Label Free ◽  
Flow Rates ◽  
Inertial Focusing ◽  
Size Dependent ◽  
Curved Channels ◽  
Aspect Ratios ◽  
Dependent Cell

Label-free, size-dependent cell-sorting applications based on inertial focusing phenomena have attracted much interest during the last decade. The separation capability heavily depends on the precision of microparticle focusing. In this study, five-loop spiral microchannels with a height of 90 µm and a width of 500 µm are introduced. Unlike their original spiral counterparts, these channels have elliptic configurations of varying initial aspect ratios, namely major axis to minor axis ratios of 3:2, 11:9, 9:11, and 2:3. Accordingly, the curvature of these configurations increases in a curvilinear manner through the channel. The effects of the alternating curvature and channel Reynolds number on the focusing of fluorescent microparticles with sizes of 10 and 20 µm in the prepared suspensions were investigated. At volumetric flow rates between 0.5 and 3.5 mL/min (allowing separation), each channel was tested to collect samples at the designated outlets. Then, these samples were analyzed by counting the particles. These curved channels were capable of separating 20 and 10 µm particles with total yields up to approximately 95% and 90%, respectively. The results exhibited that the level of enrichment and the focusing behavior of the proposed configurations are promising compared to the existing microfluidic channel configurations.

scholarly journals Enantiosensitive Bonding of Chiral Molecules on a Magnetic Substrate Investigated by Means of Electron Spectroscopies

2018 ◽  
Vol 72 (6) ◽  
pp. 418-423 ◽  
Author(s):  
Francisco J. Luque ◽  
Miguel Á. Niño ◽  
Michael J. Spilsbury ◽  
Iwona A. Kowalik ◽  
Dimitri Arvanitis ◽  
...  
Keyword(s):  
Chiral Molecules ◽  
Magnetic Substrate

scholarly journals Assessing Machine Learning versus a Mathematical Model to Estimate the Transverse Shear Stress Distribution in a Rectangular Channel

Mathematics ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 596
Author(s):  
Babak Lashkar-Ara ◽  
Niloofar Kalantari ◽  
Zohreh Sheikh Khozani ◽  
Amir Mosavi
Keyword(s):  
Shear Stress ◽  
Stress Distribution ◽  
Fuzzy Inference ◽  
Rectangular Channel ◽  
Tsallis Entropy ◽  
Shear Stress Distribution ◽  
Data Series ◽  
Shear Stresses ◽  
Inference System ◽  
Aspect Ratios

One of the most important subjects of hydraulic engineering is the reliable estimation of the transverse distribution in the rectangular channel of bed and wall shear stresses. This study makes use of the Tsallis entropy, genetic programming (GP) and adaptive neuro-fuzzy inference system (ANFIS) methods to assess the shear stress distribution (SSD) in the rectangular channel. To evaluate the results of the Tsallis entropy, GP and ANFIS models, laboratory observations were used in which shear stress was measured using an optimized Preston tube. This is then used to measure the SSD in various aspect ratios in the rectangular channel. To investigate the shear stress percentage, 10 data series with a total of 112 different data for were used. The results of the sensitivity analysis show that the most influential parameter for the SSD in smooth rectangular channel is the dimensionless parameter B/H, Where the transverse coordinate is B, and the flow depth is H. With the parameters (b/B), (B/H) for the bed and (z/H), (B/H) for the wall as inputs, the modeling of the GP was better than the other one. Based on the analysis, it can be concluded that the use of GP and ANFIS algorithms is more effective in estimating shear stress in smooth rectangular channels than the Tsallis entropy-based equations.

scholarly journals Non-linear deflection and stress analysis of laminated composite sandwich plate with elliptical cutout under different transverse loadings in hygro-thermal environment

2020 ◽  
Vol 7 (1) ◽  
pp. 80-100
Author(s):  
Rahul Kumar ◽  
Achchhe Lal ◽  
B. M. Sutaria
Keyword(s):  
Stress Concentration ◽  
Sandwich Plate ◽  
Thermal Environment ◽  
Shear Deformation Theory ◽  
Laminated Composite ◽  
Gauss Point ◽  
Composite Sandwich ◽  
Aspect Ratios ◽  
Present Solution ◽  
Non Linear

AbstractIn this paper, non-linear transverse deflection, stress and stress concentration factors (SCF) of isotropic and laminated composite sandwich plate (LCSP) with and without elliptical cutouts subjected to various trans-verse loadings in hygrothermal environment are studied. The basic formulation is based on secant function-based shear deformation theory (SFSDT) with von-Karman nonlinearity. The governing equation of non-linear deflection is derived using C0 finite element method (FEM) through minimum potential energy approach. Normalized trans-verse maximum deflections (NTMD) along with stress concentration factor is determined by using Newton’s Raphson method through Gauss point stress extrapolation. Influence of fiber orientations, load parameters, fiber volume fractions, plate span to thickness ratios, aspect ratios, thickness of core and face, position of core, boundary conditions, environmental conditions and types of transverse loading in MATLAB R2015a environment are examined. The numerical results using present solution methodology are verified with the results available in the literatures.

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