Lubrication dynamics of swollen silicones to limit long term fouling and microbial biofilms

Soft Matter ◽  
2021 ◽  
Author(s):  
Nicolas Lavielle ◽  
Dalal Asker ◽  
Benjamin D. Hatton
Keyword(s):  
Bacterial Adhesion ◽  
Liquid Interface ◽  
Microbial Biofilms

Swollen iPDMS silicones generate a liquid interface through syneresis to prevent bacterial adhesion.

scholarly journals Hyaluronic Acid and Its Composites as a Local Antimicrobial/Antiadhesive Barrier

2017 ◽  
Vol 2 (1) ◽  
pp. 63-72 ◽  
Author(s):  
C.L. Romanò ◽  
E. De Vecchi ◽  
M. Bortolin ◽  
I. Morelli ◽  
L. Drago
Keyword(s):  
Hyaluronic Acid ◽  
Bacterial Adhesion ◽  
Biofilm Formation ◽  
Microbial Colonization ◽  
Antibiofilm Activity ◽  
Clinical Settings ◽  
Bacteria And Fungi ◽  
Host Tissues ◽  
New Strategies

Abstract. Living in biofilms is probably the most common condition for bacteria and fungi and biofilm-related infections account for the majority of bacterial infectious diseases worldwide.Among others biofilm-related infections, those associated with implanted biomaterials have an enormous and still largely underestimated impact in orthopaedics and trauma, cardio-surgery and several other surgical disciplines.Given the limited efficacy of existing antibiotics in the prevention and treatment of bacterial biofilms, new strategies are needed to protect implants and host tissues, overcoming the striking ability of the microorganisms to adhere on different surfaces and to immediately protect themselves by forming the biofilm matrix.Adhesion is a necessary first step in microbial colonization and pathogenesis and provides a potential target for new preventive and treatment approach.Among various polymers, tested as antibacterial coatings, hyaluronic acid and some of its composites do offer a well-established long-term safety profile and a proven ability to reduce bacterial adhesion and biofilm formation.Aim of the present review is to summarize the available evidence concerning the antiadhesion/antibiofilm activity of hyaluronic acid and some of its derivatives to reduce/prevent bacterial adhesion and biofilm formation in various experimental and clinical settings.

Biofilm prevention potential of 0.02% polyhexanide irrigation solution in urethral catheters under practice-like in vitro conditions

2020 ◽  
Author(s):  
Florian H. H. Brill ◽  
Julia Hambach ◽  
Christian Utpatel ◽  
Diana Mogrovejo ◽  
Henrik Gabriel ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
Saline Solution ◽  
Bacterial Biofilm ◽  
Microbial Biofilms ◽  
Irrigation Solution ◽  
Term Tolerability ◽  
Prevention Potential ◽  
Saline Solutions

Abstract Background Long-term use of indwelling urethral catheters is associated with high risk of urinary tract infection (UTI) and blockage. Microbial biofilms are a common cause of catheter blockage, reduce their lifetime and significantly increase morbidity of UTIs. A 0.02% polyhexanide irrigation solution developed for routine mechanical rinsing shows potential for bacterial decolonization of suprapubic and indwelling urethral catheters and has the potential to reduce or prevent biofilm formation. Methods Using a practice-like in vitro assay and standard silicon catheters, artificially contaminated with clinically relevant bacteria, assays were carried out to evaluate the biofilm reduction and prevention potential of polyhexanide vs. no intervention (standard approach) and irrigation with saline solution (NaCl 0.9%). The biofilm mass was measured by crystal violet staining and fluorescence microscopy. Results Irrigation with a 0.02% polyhexanide solution reduced the biofilm mass by approx. 85% vs. non-treated catheters. Standard 0.9% saline solution was able to reduce the biofilm mass by approx. 50%. Fluorescence microscopy showed that polyhexanide is able to destroy bacteria in the biofilm, albeit only those cells on the upper layers. Conclusions The polyhexanide and standard saline solutions are able to reduce bacterial biofilm from urinary catheters, showing a combination of mechanical and antibacterial effects. The data supports a prevention strategy to avoid the formation of a thick biofilm, which is characteristically difficult to be efficiently removed. Further research is required to evaluate the long-term tolerability and efficacy of polyhexanide in clinical practice.

Microbial biofilms: New catalysts for maximizing productivity of long-term biotransformations

2007 ◽  
Vol 98 (6) ◽  
pp. 1123-1134 ◽  
Author(s):  
Rainer Gross ◽  
Bernhard Hauer ◽  
Katja Otto ◽  
Andreas Schmid
Keyword(s):  
Microbial Biofilms

Amino Acid-Based Zwitterionic Polymer Surfaces Highly Resist Long-Term Bacterial Adhesion

Langmuir ◽  
2016 ◽  
Vol 32 (31) ◽  
pp. 7866-7874 ◽  
Author(s):  
Qingsheng Liu ◽  
Wenchen Li ◽  
Hua Wang ◽  
Bi-min Zhang Newby ◽  
Fang Cheng ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bacterial Adhesion ◽  
Polymer Surfaces ◽  
Zwitterionic Polymer

scholarly journals Superdurable Coating Fabricated from a Double-Sided Tape with Long Term “Zero” Bacterial Adhesion

2017 ◽  
Vol 29 (34) ◽  
pp. 1606506 ◽  
Author(s):  
Wei Wang ◽  
Yang Lu ◽  
Hui Zhu ◽  
Zhiqiang Cao
Keyword(s):  
Bacterial Adhesion

scholarly journals Emerging Antibacterial Coated Dental Implants: A Preventive Measure for Peri-implantitis

2016 ◽  
Vol 7 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Varun Yarramaneni ◽  
Dhanasekar Balakrishnan ◽  
IN Aparna ◽  
Akanksha Sachdeva ◽  
Nayana Prabhu
Keyword(s):  
Dental Implants ◽  
Bacterial Adhesion ◽  
Antimicrobial Agents ◽  
Clinical Success ◽  
Preventive Measure ◽  
Titanium Implant ◽  
Success Rates ◽  
Permeable Barrier ◽  
Short And Long Term

ABSTRACT Dental implants are the modern marvel and are widely accepted as a reconstructive treatment modality for tooth replacement. In recent times, there has been a marked progress in the clinical success rates of dental implants, but implant failures as a result of infections are continuing at an alarming rate of 8% per year, translating into 1 million failures worldwide. Perimucositis and peri-implantitis are the chief complications reported postimplant surgery that effects its short- and long-term success. Peri-implantitis is characterized by clinical and radiological bone loss around the implant accompanied with an inflammatory reaction of the peri-implant mucosa and is an irreversible condition, whereas perimucositis is a reversible inflammatory change. Implant surfaces provide an ideal substrate for bacterial adhesion forming a biofilm. Biofilm performs vast functions ranging from physical defensive barrier against phagocytic predation to working as a selective permeable barrier. This limits the diffusion of systemic antimicrobial agents that are capable of damaging the bacterial complexes. These rapidly growing bacteria give rise to a chronic infection which is difficult to eradicate by conventional antibiotic therapy. To inhibit peri-implant infections, various functional modifications in the implant surfaces have been suggested. The coatings on the titanium implant are incorporated with disinfectants, antibiotics as well as antimicrobial peptides AMPs. This paper is an attempt to review all the antibiotic coatings available for a titanium implant and discuss their prospective future to prevent peri-implant infections. How to cite this article Yarramaneni V, Aparna IN, Sachdeva A, Balakrishnan D, Prabhu N. Emerging Antibacterial Coated Dental Implants: A Preventive Measure for Peri-implantitis. World J Dent 2016;7(4):195-198.

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