scholarly journals Metabolic mechanisms of a drug revealed by distortion-free 13C tracer analysis

2021 ◽  
Author(s):  
Jin Wook Cha ◽  
Xing Jin ◽  
Sihyang Jo ◽  
Yong Jin An ◽  
Sunghyouk Park

Metabolomic isotopic tracing can provide flux information useful for understanding drug mechanisms. For that, NMR has the unique advantage of giving positional isotope enrichment information, but the current 13C 1D...

Radiocarbon ◽  
1989 ◽  
Vol 31 (03) ◽  
pp. 305-310 ◽  
Author(s):  
Roy Middleton ◽  
David Fink ◽  
Jeffrey Klein ◽  
Pankaj Sharma

We have made the first measurements without pre-enrichment of 41Ca in terrestrial rock and bone samples using accelerator mass spectrometry. Although the results in tufa deposits from Egypt are in good agreement with the saturation value of 8×10-15 predicted by Raisbeck and Yiou (1979), the average 41Ca:40Ca ratio of 2×10-15 (range: 0.6 to 4.2×10-15) that we measure in modern bone is an order of magnitude lower than that obtained previously by Henning, et al (1987) on a cow bone that was measured using AMS following isotope enrichment. The low value and the variability (more than a factor of seven) of the 41Ca:40Ca ratio in modern bone make the possibility of dating bones using 41Ca unlikely.


1952 ◽  
Vol 20 (11) ◽  
pp. 1817-1817 ◽  
Author(s):  
C. C. McDonald ◽  
H. E. Gunning
Keyword(s):  

2009 ◽  
Vol 184 (4) ◽  
pp. 944-949 ◽  
Author(s):  
S. J. Woodin ◽  
R. van der Wal ◽  
M. Sommerkorn ◽  
J. L. Gornall

1997 ◽  
Vol 75 (1) ◽  
pp. 45-53 ◽  
Author(s):  
C A Fisher ◽  
J Wang ◽  
G A Francis ◽  
B D Sykes ◽  
C M Kay ◽  
...  

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