scholarly journals Efficient cleavage of tertiary amide bonds via radical–polar crossover using a copper(ii) bromide/Selectfluor hybrid system

2020 ◽  
Vol 11 (45) ◽  
pp. 12323-12328
Author(s):  
Zhe Wang ◽  
Akira Matsumoto ◽  
Keiji Maruoka
Keyword(s):  
Hybrid System ◽  
Amide Bonds ◽  
Tertiary Amide ◽  
Novel Approach ◽  
System P ◽  
Tertiary Amides

A novel approach for the efficient cleavage of the amide bonds in tertiary amides is reported.

Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo

2018 ◽  
Author(s):  
Benjamin Stenton ◽  
Bruno Oliveira ◽  
João Conde ◽  
Magda Negrão ◽  
Miguel Godinho Ferreira ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Xenograft Model ◽  
Amide Bonds ◽  
Control Drug ◽  
Tertiary Amide ◽  
Platinum Salts ◽  
First Choice ◽  
Tertiary Amides ◽  
Drug Activation

<p>Creating ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of exogenous triggers offers the possibility for precise and traceless drug activation. However, ensuring localization of the trigger as well as the prodrug at the diseased tissue is complex while essential for therapeutic efficacy and to avoid side-toxicity. Cisplatin remains a first line option to treat 20% of all cancer patients and while clearing after 30 min from blood it concentrates in tumor tissues. Here, we demonstrate the use of the platinum-mediated bond cleavage of protected tertiary amides, which can occur in a catalytic manner under bioorthogonal conditions. Protected analogues of cytotoxic drugs 5-fluorouracil (5-FU) and monomethyl auristatin E (MMAE) were successfully activated using non-toxic amounts of platinum salts in cells. An otherwise fully stable and non-internalizing ADC built using a bifunctional linker featuring a tertiary amide protected MMAE was also bioorthogonally decaged in the presence of platinum salts for extracellular drug release. Finally, cisplatin-mediated activation of a prodrug 5-FU was shown in a colorectal zebrafish xenograft model leading to a significant tumor reduction. Considering cisplatin’s continued use as a first-choice treatment for many solid cancers and especially in colorectal cancer, we anticipate that our platinum-mediated decaging strategy will enhance cancer therapy by allowing tumor specific prodrug activation.</p>

Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo

2018 ◽  
Author(s):  
Benjamin Stenton ◽  
Bruno Oliveira ◽  
João Conde ◽  
Magda Negrão ◽  
Miguel Godinho Ferreira ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Xenograft Model ◽  
Amide Bonds ◽  
Control Drug ◽  
Tertiary Amide ◽  
Platinum Salts ◽  
First Choice ◽  
Tertiary Amides ◽  
Drug Activation

<p>Creating ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of exogenous triggers offers the possibility for precise and traceless drug activation. However, ensuring localization of the trigger as well as the prodrug at the diseased tissue is complex while essential for therapeutic efficacy and to avoid side-toxicity. Cisplatin remains a first line option to treat 20% of all cancer patients and while clearing after 30 min from blood it concentrates in tumor tissues. Here, we demonstrate the use of the platinum-mediated bond cleavage of protected tertiary amides, which can occur in a catalytic manner under bioorthogonal conditions. Protected analogues of cytotoxic drugs 5-fluorouracil (5-FU) and monomethyl auristatin E (MMAE) were successfully activated using non-toxic amounts of platinum salts in cells. An otherwise fully stable and non-internalizing ADC built using a bifunctional linker featuring a tertiary amide protected MMAE was also bioorthogonally decaged in the presence of platinum salts for extracellular drug release. Finally, cisplatin-mediated activation of a prodrug 5-FU was shown in a colorectal zebrafish xenograft model leading to a significant tumor reduction. Considering cisplatin’s continued use as a first-choice treatment for many solid cancers and especially in colorectal cancer, we anticipate that our platinum-mediated decaging strategy will enhance cancer therapy by allowing tumor specific prodrug activation.</p>

Defence Investigative Ethics

2020 ◽  
pp. 251-281
Author(s):  
Michael G. Karnavas
Keyword(s):  
Best Practices ◽  
Hybrid System ◽  
International Criminal ◽  
Civil Law ◽  
International Criminal Tribunal ◽  
Former Yugoslavia ◽  
Practical Advice ◽  
System P ◽  
Defence Counsel ◽  
Trial Advocacy

The investigation of war crimes has proved to be a challenging task for the Defence at the International Criminal Tribunal for the former Yugoslavia (ICTY). At the Court’s infancy, civil trained defence counsel with no experience in adversarial party-driven procedures were unfamiliar with aspects of case preparation and trial advocacy, such as gathering evidence by conducting their own investigation, or cross-examination through leading questions based on a coherent theory of the case. These adversarial modalities also came with specific ethical duties. This chapter offers some practical advice and best practices relevant to Defence Counsel practising in national jurisdictions of the former Yugoslavia region and elsewhere, where adversarial modalities similar to those found in the ICTY procedure have been adopted in reforming their criminal procedures—transitioning them from civil law to a more hybrid system.

Novel photofunctional hybrid materials (alumina and titania) functionalized with both MOF and lanthanide complexes through coordination bonds

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38761-38768 ◽  
Author(s):  
X. Y. Xu ◽  
B. Yan
Keyword(s):  
Hybrid Materials ◽  
Hybrid System ◽  
Lanthanide Complexes ◽  
Metal Organic Framework ◽  
Sol Gel ◽  
System P ◽  
Metal Organic ◽  
Coordination Bonds ◽  
Organic Framework

Multi-component sol–gel derived alumina and titania hybrid materials are assembled by the functionalization of both lanthanide complexes and a special metal organic framework compound: Al-MIL-53-COOH through coordination bonds. Multi-color luminescence and white colored light can be tuned by controlling the different units in the hybrid system.

Energetically self-sustaining treatment of swine wastewater in a microbial electrochemical technology-centered hybrid system

2020 ◽  
Vol 6 (3) ◽  
pp. 747-756 ◽  
Author(s):  
Haiman Wang ◽  
Zhuang Miao ◽  
Yafeng Li ◽  
Weihua He ◽  
Youpeng Qu ◽  
...  
Keyword(s):  
Organic Matter ◽  
Hybrid System ◽  
Nitrogen Removal ◽  
Swine Wastewater ◽  
Current Generation ◽  
Organic Matter Removal ◽  
Electrochemical Technology ◽  
System P

A MES-centered hybrid system was developed with well-matched current generation, efficient organic matter removal and subsequent nitrogen removal.

scholarly journals Fabrication of Self-Healable Magnetic Nanocomposites via Diels−Alder Click Chemistry

2019 ◽  
Vol 9 (3) ◽  
pp. 506 ◽  
Author(s):  
Yi-Huan Lee ◽  
Yan-Nian Zhuang ◽  
Hsin-Ta Wang ◽  
Ming-Feng Wei ◽  
Wen-Chi Ko ◽  
...  
Keyword(s):  
Hybrid System ◽  
Glycidyl Ether ◽  
Magnetic Behavior ◽  
Diels Alder ◽  
Hybrid Network ◽  
Organic Polymer ◽  
Self Healing ◽  
Multiwalled Carbon ◽  
Novel Approach ◽  
Superparamagnetic Properties

In this study, we report a novel approach to fabricate an organic/inorganic magnetic hybrid system capable of self-healing, wherein a polycaprolactone-poly(furfuryl glycidyl ether) copolymer (PCLF) serving as the structure template was first synthesized, followed by the incorporation of iron oxide nanoparticles-decorated multiwalled carbon nanotubes (IONPs-MWCNTs) and 1,1′-(methylenedi-4,1-phenylene)bismaleimide (BMI) into the polymer matrix to form a covalently crosslinked hybrid network via a Diels−Alder (DA) reaction. For this system, the reactive combination of diene and dienophile from furan/maleimide, MWCNT/furan, and MWCNT/maleimide could facilely induce multiple DA reactions that imparted a versatile route to efficiently introduce IONPs-MWCNTs into the organic polymer hosts, resulting in a uniform distribution of IONPs-MWCNTs that led to a hybrid system with superparamagnetic properties. Beside the magnetic behavior, such material synergistically exhibited a superior ability for healing scratch defects via a retro-DA reaction. Therefore, this crosslinked PCLF/BMI/IONPs-MWCNTs hybrid system which exhibits multifunctional properties including superparamagnetic behavior and self-repairability can serve as an intelligent material for developing advanced electromagnetic applications.

Coherent resonance of quantum plasmons in the graphene–gold cluster hybrid system

2015 ◽  
Vol 17 (18) ◽  
pp. 12051-12055 ◽  
Author(s):  
Kaibiao Zhang ◽  
Hong Zhang ◽  
Chikang Li
Keyword(s):  
Optical Properties ◽  
Metal Nanoparticles ◽  
Noble Metal ◽  
Hybrid System ◽  
Gold Cluster ◽  
Noble Metal Nanoparticles ◽  
System P ◽  
Coherent Resonance

Noble metal nanoparticles can modify the optical properties of graphene.

Photocatalytic degradation of phenol by the heterogeneous Fe3O4 nanoparticles and oxalate complex system

RSC Advances ◽  
2014 ◽  
Vol 4 (77) ◽  
pp. 40828-40836 ◽  
Author(s):  
Piao Xu ◽  
Guangming Zeng ◽  
Danlian Huang ◽  
Liang Liu ◽  
Cui Lai ◽  
...  
Keyword(s):  
Complex System ◽  
Photocatalytic Degradation ◽  
Fe3o4 Nanoparticles ◽  
Radical Mechanism ◽  
Phenol Removal ◽  
Oxalate Complex ◽  
Novel Approach ◽  
System P

A novel approach for phenol removal using Fe3O4 nanoparticles and oxalate was proposed via a radical mechanism.

scholarly journals Proteoliposomes as energy transferring nanomaterials: enhancing the spectral range of light-harvesting proteins using lipid-linked chromophores

Nanoscale ◽  
2019 ◽  
Vol 11 (35) ◽  
pp. 16284-16292 ◽  
Author(s):  
Ashley M. Hancock ◽  
Sophie A. Meredith ◽  
Simon D. Connell ◽  
Lars J. C. Jeuken ◽  
Peter G. Adams
Keyword(s):  
Energy Transfer ◽  
Hybrid System ◽  
Spectral Range ◽  
Light Harvesting ◽  
Efficient Energy Transfer ◽  
Efficient Energy ◽  
Highly Efficient ◽  
Effective Absorption ◽  
System P ◽  
Texas Red

Self-assembled proteoliposomes allow highly efficient energy transfer from the spectrally-complementary chromophore Texas Red to the plant light-harvesting protein LHCII, increasing the effective absorption range of this bio-hybrid system.

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