scholarly journals Enhancing the ROS generation ability of a rhodamine-decorated iridium(iii) complex by ligand regulation for endoplasmic reticulum-targeted photodynamic therapy

2020 ◽  
Vol 11 (44) ◽  
pp. 12212-12220
Author(s):  
Lihua Zhou ◽  
Fangfang Wei ◽  
Jingjing Xiang ◽  
Hongfeng Li ◽  
Chunbin Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Photodynamic Therapy ◽  
Design Strategy ◽  
Ros Generation ◽  
Ligand Regulation ◽  
Targeted Photodynamic Therapy

A design strategy for boosting the ROS generation of rhodamine-decorated cyclometallated iridium(iii) complexes by ligand regulation for endoplasmic reticulum-targeted precise photodynamic therapy.

Scavenger-Receptor Targeted Photodynamic Therapy¶

2000 ◽  
Vol 72 (4) ◽  
pp. 533 ◽  
Author(s):  
Michael R. Hamblin ◽  
Jaimie L. Miller ◽  
Bernhard Ortel
Keyword(s):  
Photodynamic Therapy ◽  
Scavenger Receptor ◽  
Targeted Photodynamic Therapy

scholarly journals Nanoscale Metal–Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy

2021 ◽  
Vol 143 (5) ◽  
pp. 2194-2199 ◽  
Author(s):  
Geoffrey T. Nash ◽  
Taokun Luo ◽  
Guangxu Lan ◽  
Kaiyuan Ni ◽  
Michael Kaufmann ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Organic Layer ◽  
Metal Organic ◽  
Targeted Photodynamic Therapy

scholarly journals Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells

APOPTOSIS ◽  
2021 ◽  
Author(s):  
Michela Raimondi ◽  
Fabrizio Fontana ◽  
Monica Marzagalli ◽  
Matteo Audano ◽  
Giangiacomo Beretta ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Atp Synthesis ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Ros Generation ◽  
Therapy Outcomes ◽  
Human Melanoma Cells ◽  
Oxphos Complex

Abstract Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated that δ-TT triggers apoptosis in human melanoma cells. Here, we investigated whether it might also activate paraptosis, a non-canonical programmed cell death. In accordance with the main paraptotic features, δ-TT was shown to promote cytoplasmic vacuolization, associated with endoplasmic reticulum/mitochondrial dilation and protein synthesis, as well as MAPK activation in A375 and BLM cell lines. Moreover, treated cells exhibited a significant reduced expression of OXPHOS complex I and a marked decrease in oxygen consumption and mitochondrial membrane potential, culminating in decreased ATP synthesis and AMPK phosphorylation. This mitochondrial dysfunction resulted in ROS overproduction, found to be responsible for paraptosis induction. Additionally, δ-TT caused Ca2+ homeostasis disruption, with endoplasmic reticulum-derived ions accumulating in mitochondria and activating the paraptotic signaling. Interestingly, by using both IP3R and VDAC inhibitors, a close cause-effect relationship between mitochondrial Ca2+ overload and ROS generation was evidenced. Collectively, these results provide novel insights into δ-TT anti-melanoma activity, highlighting its ability to induce mitochondrial dysfunction-mediated paraptosis. Graphic Abstract δ-tocotrienol induces paraptotic cell death in human melanoma cells, causing endoplasmic reticulum dilation and mitochondrial swelling. These alterations induce an impairment of mitochondrial function, ROS production and calcium overload.

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