Development of Therapeutic Au–Methylene Blue Nanoparticles for Targeted Photodynamic Therapy of Cervical Cancer Cells

2014 ◽  
Vol 7 (1) ◽  
pp. 432-441 ◽  
Author(s):  
Jiashing Yu ◽  
Che-Hao Hsu ◽  
Chih-Chia Huang ◽  
Po-Yang Chang
Keyword(s):  
Cervical Cancer ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cervical Cancer Cells ◽  
Targeted Photodynamic Therapy

scholarly journals Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Laura Marise de Freitas ◽  
Rodolfo Bortolozo Serafim ◽  
Juliana Ferreira de Sousa ◽  
Thaís Fernanda Moreira ◽  
Cláudia Tavares dos Santos ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cervical Cancer Cells

scholarly journals Fabrication of Anisotropic Cu Ferrite-Polymer Core-Shell Nanoparticles for Photodynamic Ablation of Cervical Cancer Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2429
Author(s):  
Shuo-Hsiu Kuo ◽  
Po-Ting Wu ◽  
Jing-Yin Huang ◽  
Chin-Pao Chiu ◽  
Jiashing Yu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Hydrothermal Reaction ◽  
Red Light ◽  
The Body ◽  
Oxygen Species ◽  
Shell Nanoparticles ◽  
Thiazolyl Blue Tetrazolium Bromide ◽  
Cervical Cancer Cells

In this work we developed methylene blue-immobilized copper-iron nanoparticles (MB-CuFe NPs) through a facile one-step hydrothermal reaction to achieve a better phototherapeutic effect. The Fe/Cu ratio of the CuFe NPs was controllable by merely changing the loading amount of iron precursor concentration. The CuFe NPs could serve as a Fenton catalyst to convert hydrogen peroxide (H2O2) into reactive oxygen species (ROS), while the superparamagnetic properties also suggest magnetic resonance imaging (MRI) potential. Furthermore, the Food and Drug Administration (FDA)-approved MB photosensitizer could strongly adsorb onto the surface of CuFe NPs to facilitate the drug delivery into cells and improve the photodynamic therapy at 660 nm via significant generation of singlet oxygen species, leading to enhanced cancer cell-damaging efficacy. An MTT (thiazolyl blue tetrazolium bromide) assay proved the low cytotoxicity of the CuFe NPs to cervical cancer cells (HeLa cells), namely above 80% at 25 ppm of the sample dose. A slight dissolution of Cu and Fe ions from the CuFe NPs in an acidic environment was obtained, providing direct evidence for CuFe NPs being degradable without the risk of long-term retention in the body. Moreover, the tremendous photo-to-thermal conversion of CuFe NPs was examined, which might be combined with photodynamic therapy (PDT) for promising development in the depletion of cancer cells after a single pulse of deep-red light irradiation at high laser power.

scholarly journals Involvement of retinoblastoma-associated protein 48 during photodynamic therapy of cervical cancer cells

2017 ◽  
Vol 15 (3) ◽  
pp. 1393-1400 ◽  
Author(s):  
Shuxia Wu ◽  
Lijun Wang ◽  
Xingye Ren ◽  
Yulu Pan ◽  
Yan Peng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cervical Cancer Cells
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