scholarly journals Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma

2020 ◽  
Vol 11 (43) ◽  
pp. 11740-11762 ◽  
Author(s):  
Liubov M. Lifshits ◽  
John A. Roque III ◽  
Prathyusha Konda ◽  
Susan Monro ◽  
Houston D. Cole ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Melanoma Cells ◽  
Tumor Challenge

Ru(ii) photosensitizers (PSs) destroy aggressive melanoma cells, triggering an immune response that leads to protection against tumor challenge and mouse survival.

Factors Affecting Photodynamic Therapy and Anti-Tumor Immune Response

2020 ◽  
Vol 21 (2) ◽  
pp. 123-136
Author(s):  
Michael R. Hamblin ◽  
Heidi Abrahamse
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Immune System ◽  
Near Infrared ◽  
Checkpoint Inhibitors ◽  
Infrared Light ◽  
Delivery Mode ◽  
Host Immune System ◽  
Systemic Injection ◽  
Clinical Scenarios

: Photodynamic Therapy (PDT) is a cancer therapy involving the systemic injection of a Photosensitizer (PS) that localizes to some extent in a tumor. After an appropriate time (ranging from minutes to days), the tumor is irradiated with red or near-infrared light either as a surface spot or by interstitial optical fibers. The PS is excited by the light to form a long-lived triplet state that can react with ambient oxygen to produce Reactive Oxygen Species (ROS) such as singlet oxygen and/or hydroxyl radicals, that kill tumor cells, destroy tumor blood vessels, and lead to tumor regression and necrosis. It has long been realized that in some cases, PDT can also stimulate the host immune system, leading to a systemic anti-tumor immune response that can also destroy distant metastases and guard against tumor recurrence. The present paper aims to cover some of the factors that can affect the likelihood and efficiency of this immune response. The structure of the PS, drug-light interval, rate of light delivery, mode of cancer cell death, expression of tumor-associated antigens, and combinations of PDT with various adjuvants all can play a role in stimulating the host immune system. Considering the recent revolution in tumor immunotherapy triggered by the success of checkpoint inhibitors, it appears that the time is ripe for PDT to be investigated in combination with other approaches in clinical scenarios.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Immune Response Against Angiosarcoma Following Lower Fluence Rate Clinical Photodynamic Therapy

2008 ◽  
Vol 27 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Patricia S.P. Thong ◽  
Malini Olivo ◽  
Kiang-Wei Kho ◽  
Ramaswamy Bhuvaneswari ◽  
William W. L. Chin ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Fluence Rate

scholarly journals Artificial Cell-Mediated Photodynamic Therapy Enhanced Anticancer Efficacy through Combination of Tumor Disruption and Immune Response Stimulation

ACS Omega ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 12727-12735 ◽  
Author(s):  
Jiang Ni ◽  
Ying Sun ◽  
Jinfang Song ◽  
Yiqing Zhao ◽  
Qiufang Gao ◽  
...  
Keyword(s):  
Immune Response ◽  
Photodynamic Therapy ◽  
Anticancer Efficacy ◽  
Artificial Cell

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2021 ◽  
pp. 2002177
Author(s):  
Hongxin Lin ◽  
Zexi Lin ◽  
Konghua Zheng ◽  
Chenlu Wang ◽  
Lisheng Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

Synthesis of a near infrared-actuated phthalocyanine-lipid vesicle system for augmented photodynamic therapy

2021 ◽  
Vol 278 ◽  
pp. 116811
Author(s):  
Nnamdi Nwahara ◽  
Muthumuni Managa ◽  
Mihlali Stoffels ◽  
Jonathan Britton ◽  
Earl Prinsloo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Lipid Vesicle

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

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