Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell

Chemical Science ◽

10.1039/d0sc03636f ◽

2021 ◽

Author(s):

Yongzheng Cong ◽

Khatereh Motamedchaboki ◽

Santosh A. Misal ◽

Yiran Liang ◽

Amanda J. Guise ◽

...

Keyword(s):

Mass Spectrometry ◽

Sample Preparation ◽

Single Cell ◽

Mammalian Cell ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Low Flow ◽

Proteome Profiling ◽

Cell Proteome

The combination of nanodroplet sample preparation, ultra-low-flow nanoLC, high-field asymmetric ion mobility spectrometry (FAIMS) and latest-generation mass spectrometry instrumentation provides dramatically improved single-cell proteome profiling.

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Compensation voltage shifting in high-field asymmetric waveform ion mobility spectrometry-mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2739 ◽

2006 ◽

Vol 20 (22) ◽

pp. 3319-3329 ◽

Cited By ~ 17

Author(s):

Beata M. Kolakowski ◽

Margaret A. McCooeye ◽

Zoltan Mester

Keyword(s):

Mass Spectrometry ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Compensation Voltage ◽

Asymmetric Waveform

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Calculation of ion mobilities from electrospray ionization high-field asymmetric waveform ion mobility spectrometry mass spectrometry

The Journal of Chemical Physics ◽

10.1063/1.1372186 ◽

2001 ◽

Vol 114 (23) ◽

pp. 10270-10277 ◽

Cited By ~ 42

Author(s):

Roger Guevremont ◽

David A. Barnett ◽

Randy W. Purves ◽

Larry A. Viehland

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Asymmetric Waveform

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Characterization of Crude Oil and Its Saturate, Aromatic, and Resin Fractions by High-Field Asymmetric Waveform Ion Mobility Spectrometry–High-Resolution Mass Spectrometry

Energy & Fuels ◽

10.1021/acs.energyfuels.8b02718 ◽

2018 ◽

Vol 32 (11) ◽

pp. 11310-11316 ◽

Cited By ~ 3

Author(s):

Katarzyna M. Szykuła ◽

Christianne Wicking ◽

Samuel Whitmarsh ◽

Colin S. Creaser ◽

James C. Reynolds

Keyword(s):

Mass Spectrometry ◽

High Resolution ◽

Crude Oil ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

High Resolution Mass Spectrometry ◽

Asymmetric Waveform ◽

Resolution Mass

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Liquid Extraction Surface Analysis (LESA) High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins

Methods in Molecular Biology - Ion Mobility-Mass Spectrometry ◽

10.1007/978-1-0716-0030-6_12 ◽

2019 ◽

pp. 191-201

Author(s):

Rian L. Griffiths ◽

Klaudia I. Kocurek ◽

Helen J. Cooper

Keyword(s):

Mass Spectrometry ◽

Surface Analysis ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Liquid Extraction ◽

Asymmetric Waveform ◽

Intact Proteins ◽

Liquid Extraction Surface Analysis

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High-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled with high-resolution electron transfer dissociation mass spectrometry for the analysis of isobaric phosphopeptides

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4101 ◽

2009 ◽

Vol 23 (13) ◽

pp. 1963-1969 ◽

Cited By ~ 65

Author(s):

Yue Xuan ◽

Andrew J. Creese ◽

Julie A. Horner ◽

Helen J. Cooper

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

High Resolution ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Electron Transfer Dissociation ◽

Asymmetric Waveform ◽

Resolution Electron

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Analysis of Chemical Warfare Agents in Food Products by Atmospheric Pressure Ionization-High Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac070816j ◽

2007 ◽

Vol 79 (21) ◽

pp. 8257-8265 ◽

Cited By ~ 35

Author(s):

Beata M. Kolakowski ◽

Paul A. D'Agostino ◽

Claude Chenier ◽

Zoltán Mester

Keyword(s):

Mass Spectrometry ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

Atmospheric Pressure ◽

High Field ◽

Chemical Warfare Agents ◽

Chemical Warfare ◽

Asymmetric Waveform ◽

Atmospheric Pressure Ionization ◽

Warfare Agents

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Analysis of paralytic shellfish toxins using high-field asymmetric waveform ion mobility spectrometry with liquid chromatography-mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-015-8488-6 ◽

2015 ◽

Vol 407 (9) ◽

pp. 2473-2484 ◽

Cited By ~ 25

Author(s):

Daniel G. Beach ◽

Jeremy E. Melanson ◽

Randy W. Purves

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Asymmetric Waveform ◽

Liquid Chromatography Mass Spectrometry ◽

Shellfish Toxins ◽

Paralytic Shellfish Toxins ◽

Paralytic Shellfish

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Separation and Quantitation of the Stereoisomers of Ephedra Alkaloids in Natural Health Products Using Flow Injection-Electrospray Ionization-High Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac0342020 ◽

2003 ◽

Vol 75 (11) ◽

pp. 2538-2542 ◽

Cited By ~ 52

Author(s):

Margaret McCooeye ◽

Luyi Ding ◽

Graeme J. Gardner ◽

Catharine A. Fraser ◽

Joe Lam ◽

...

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Ion Mobility Spectrometry ◽

Flow Injection ◽

Ion Mobility ◽

High Field ◽

Natural Health Products ◽

Asymmetric Waveform ◽

Natural Health ◽

Health Products

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Separation of protein conformers using electrospray-high field asymmetric waveform ion mobility spectrometry-mass spectrometry

International Journal of Mass Spectrometry ◽

10.1016/s1387-3806(99)00240-7 ◽

2000 ◽

Vol 197 (1-3) ◽

pp. 163-177 ◽

Cited By ~ 49

Author(s):

Randy W Purves ◽

David A Barnett ◽

Roger Guevremont

Keyword(s):

Mass Spectrometry ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Asymmetric Waveform

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Quantitation of Amphetamine, Methamphetamine, and Their Methylenedioxy Derivatives in Urine by Solid-Phase Microextraction Coupled with Electrospray Ionization−High-Field Asymmetric Waveform Ion Mobility Spectrometry−Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac011296+ ◽

2002 ◽

Vol 74 (13) ◽

pp. 3071-3075 ◽

Cited By ~ 61

Author(s):

Margaret A. McCooeye ◽

Zoltán Mester ◽

Barbara Ells ◽

David A. Barnett ◽

Randy W. Purves ◽

...

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

High Field ◽

Solid Phase Microextraction ◽

Solid Phase ◽

Asymmetric Waveform

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