scholarly journals N2Phos – an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

2020 ◽  
Vol 11 (20) ◽  
pp. 5205-5212
Author(s):  
Nnamdi Akporji ◽  
Ruchita R. Thakore ◽  
Margery Cortes-Clerget ◽  
Joel Andersen ◽  
Evan Landstrom ◽  
...  
Keyword(s):  
Active Catalyst ◽  
Micellar Medium ◽  
Aryl Chlorides ◽  
Highly Effective ◽  
Aqueous Micellar Medium ◽  
Ppm Level

A new, biaryl phosphine-containing ligand, N2Phos, forms a 1 : 1 complex with Pd resulting in an active catalyst at the ppm level for Suzuki–Miyaura couplings in water, enabled by an aqueous micellar medium. Notably, aryl chlorides are shown to be amenable substrates.

scholarly journals A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

2019 ◽  
Vol 10 (38) ◽  
pp. 8825-8831 ◽  
Author(s):  
Balaram S. Takale ◽  
Ruchita R. Thakore ◽  
Sachin Handa ◽  
Fabrice Gallou ◽  
John Reilly ◽  
...  
Keyword(s):  
Pd Catalyst ◽  
Micellar Medium ◽  
Mild Conditions ◽  
Aqueous Micellar Medium ◽  
Ppm Level

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki–Miyaura couplings to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst.

scholarly journals Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3917
Author(s):  
Sofia Siciliano ◽  
Elena Cini ◽  
Maurizio Taddei ◽  
Giorgia Vinciarelli
Keyword(s):  
Water Environment ◽  
Delivery Mode ◽  
Micellar Medium ◽  
Dielectric Heating ◽  
Microwave Dielectric ◽  
Microwave Dielectric Heating ◽  
Heating Mode ◽  
Aqueous Micellar Medium ◽  
By Products ◽  
Better Than

The synthesis of 2-substituted indoles starting from the corresponding unprotected 2-alkynylanilines was made possible in 3% TPGS-750-M water using Pd(OAc)2 alone as the catalyst. The reaction was sensitive to the heating mode respect to the nature of the starting material as, in many cases, convectional heating was better than microwave dielectric heating. The MW (microwave) delivery mode had also an influence in the formation of by-products and, consequently, product yields. A tandem Sonogashira-cyclisation reaction was also accomplished using Pd(OAc)2/Xphos in the nanomicellar water environment.

Captopril as a nucleophile for ester cleavage. Formation of the thiolester S-benzoylcaptopril

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 45740-45748 ◽  
Author(s):  
Emilia Iglesias ◽  
Isabel Brandariz
Keyword(s):  
Micellar Medium ◽  
Carbonate Buffer ◽  
Aqueous Micellar Medium

The reaction between captopril and phenylbenzoate yields S-benzoylcaptopril that is very stable in a carbonate buffer or in an aqueous micellar medium.

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