scholarly journals A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

2019 ◽  
Vol 10 (38) ◽  
pp. 8825-8831 ◽  
Author(s):  
Balaram S. Takale ◽  
Ruchita R. Thakore ◽  
Sachin Handa ◽  
Fabrice Gallou ◽  
John Reilly ◽  
...  
Keyword(s):  
Pd Catalyst ◽  
Micellar Medium ◽  
Mild Conditions ◽  
Aqueous Micellar Medium ◽  
Ppm Level

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki–Miyaura couplings to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst.

scholarly journals N2Phos – an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

2020 ◽  
Vol 11 (20) ◽  
pp. 5205-5212
Author(s):  
Nnamdi Akporji ◽  
Ruchita R. Thakore ◽  
Margery Cortes-Clerget ◽  
Joel Andersen ◽  
Evan Landstrom ◽  
...  
Keyword(s):  
Active Catalyst ◽  
Micellar Medium ◽  
Aryl Chlorides ◽  
Highly Effective ◽  
Aqueous Micellar Medium ◽  
Ppm Level

A new, biaryl phosphine-containing ligand, N2Phos, forms a 1 : 1 complex with Pd resulting in an active catalyst at the ppm level for Suzuki–Miyaura couplings in water, enabled by an aqueous micellar medium. Notably, aryl chlorides are shown to be amenable substrates.

scholarly journals Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3917
Author(s):  
Sofia Siciliano ◽  
Elena Cini ◽  
Maurizio Taddei ◽  
Giorgia Vinciarelli
Keyword(s):  
Water Environment ◽  
Delivery Mode ◽  
Micellar Medium ◽  
Dielectric Heating ◽  
Microwave Dielectric ◽  
Microwave Dielectric Heating ◽  
Heating Mode ◽  
Aqueous Micellar Medium ◽  
By Products ◽  
Better Than

The synthesis of 2-substituted indoles starting from the corresponding unprotected 2-alkynylanilines was made possible in 3% TPGS-750-M water using Pd(OAc)2 alone as the catalyst. The reaction was sensitive to the heating mode respect to the nature of the starting material as, in many cases, convectional heating was better than microwave dielectric heating. The MW (microwave) delivery mode had also an influence in the formation of by-products and, consequently, product yields. A tandem Sonogashira-cyclisation reaction was also accomplished using Pd(OAc)2/Xphos in the nanomicellar water environment.

Captopril as a nucleophile for ester cleavage. Formation of the thiolester S-benzoylcaptopril

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 45740-45748 ◽  
Author(s):  
Emilia Iglesias ◽  
Isabel Brandariz
Keyword(s):  
Micellar Medium ◽  
Carbonate Buffer ◽  
Aqueous Micellar Medium

The reaction between captopril and phenylbenzoate yields S-benzoylcaptopril that is very stable in a carbonate buffer or in an aqueous micellar medium.

scholarly journals Low Temperature Chemoselective Hydrogenation of Aldehydes over a Magnetic Pd Catalyst

2019 ◽  
Vol 9 (9) ◽  
pp. 1792
Author(s):  
Liu ◽  
Wang ◽  
Gao ◽  
Wang ◽  
Cheng ◽  
...  
Keyword(s):  
Low Temperature ◽  
Room Temperature ◽  
Heterogeneous Catalysts ◽  
Aromatic Aldehydes ◽  
Pd Catalyst ◽  
Primary Alcohols ◽  
Mild Conditions ◽  
Excellent Yield ◽  
Chemoselective Hydrogenation ◽  
Supported Palladium

Chemoselective hydrogenation of aldehydes with heterogeneous catalysts under mild conditions is of great importance but remains a major challenge. Herein, an efficient strategy was developed for low temperature chemoselective hydrogenation of aldehydes with broad substrate scope over a magnetic material supported palladium catalyst (γ-Fe2O3@HAP-Pd). Aldehydes bearing various reducible functional groups readily underwent hydrogenation to give the corresponding primary alcohols with moderate to excellent yield at room temperature in aqueous solutions. The Hammett equation revealed that the hydrogenation of aromatic aldehydes proceeded via an anionic intermediate. Additionally, when the temperature increased to 70 °C, toluene was obtained by the deoxygenation of benzaldehyde in excellent yield. Furthermore, the γ-Fe2O3@HAP-Pd could be recycled up to six times without loss of activity and metal leaching.

Magnetically Separable Pd Catalyst for Highly Selective Epoxide Hydrogenolysis under Mild Conditions

2007 ◽  
Vol 9 (17) ◽  
pp. 3417-3419 ◽  
Author(s):  
Min Serk Kwon ◽  
In Soo Park ◽  
Jum Suk Jang ◽  
Jae Sung Lee ◽  
Jaiwook Park
Keyword(s):  
Pd Catalyst ◽  
Mild Conditions ◽  
Magnetically Separable
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