scholarly journals Cytotoxic constituents and a new hydroxycinnamic acid derivative from Leontodon saxatilis (Asteraceae, Cichorieae)

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10489-10496
Author(s):  
Serhat Sezai Ҫiҫek ◽  
Johanna Willer ◽  
Francesca Preziuso ◽  
Frank Sönnichsen ◽  
Richard Greil ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Hydroxycinnamic Acid ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Hydroxycinnamic Acid Derivative

Phytochemical investigation of the aerial parts of Leontodon saxatilis yielded six compounds with antimyeloma activity as well as crepidiaside A as a chemophenetic marker and 5-feruloyl-2α-hydroxyquinic acid as a new hydroxycinnamic acid derivative.

A novel trans-4-hydroxycinnamic acid derivative from Meyer lemon (Citrus meyeri)

2012 ◽  
Vol 135 (4) ◽  
pp. 2235-2237 ◽  
Author(s):  
Yoshiaki Miyake ◽  
Chihiro Ito ◽  
Masataka Itoigawa
Keyword(s):  
Acid Derivative ◽  
Hydroxycinnamic Acid ◽  
Hydroxycinnamic Acid Derivative

scholarly journals Four New Pterosins from Pteris cretica and Their Cytotoxic Activities

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2767
Author(s):  
Jian Lu ◽  
Caiying Peng ◽  
Shuang Cheng ◽  
Jianqun Liu ◽  
Qinge Ma ◽  
...  
Keyword(s):  
Human Tumor ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Aerial Parts ◽  
Pteris Cretica ◽  
Phytochemical Investigation ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
New Compounds

Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-β-d-glucopyranoside (4), together with five known pterosins 5–9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1 and 3 were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds 1 and 2 exhibited cytotoxic activity against HCT-116 cells with IC50 value of 22.4 μM and 15.8 μM, respectively.

scholarly journals Anti-inflammatory Constituents from the Aerial Parts of Iris minutiaurea

2016 ◽  
Vol 11 (6) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Kyeong Wan Woo ◽  
Ki Ho Lee ◽  
Ji Hun Jang ◽  
Min Suk Kim ◽  
Hyun Woo Cho ◽  
...  
Keyword(s):  
Proinflammatory Cytokine ◽  
Fast Atom Bombardment ◽  
Methanol Extract ◽  
2D Nmr ◽  
Flavonoid Glycoside ◽  
Enzyme Hydrolysis ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Tnf Α ◽  
Anti Inflammatory

Phytochemical investigation of the methanol extract of the aerial parts of Iris minutiaurea (Iridaceae) using column chromatography led to the isolation of a new xanthone glycoside, 1-hydroxy-3,5-dimethoxy-xanthone-6- O-β-D-glucoside (1), together with one known flavonoid glycoside (2). The structure of this new compound was elucidated by analysis of spectroscopic, including ID (1H, 13C), 2D NMR (COSY, HMQC, HMBC), and high resolution fast atom bombardment mass spectrometric (HR-FAB-MS) data and enzyme hydrolysis. We found that compounds 1 and 2 significantly suppressed production of NO, and pro-inflammatory cytokine in LPS-induced RAW264.7 cells. These results suggest that compound 1 and 2 have anti-inflammatory activity related with production of TNF-α, IL-6, IL-β, and NO in macrophages, and then compound 1 were more efficient than compound 2 in lowering the level of proinflammatory cytokine.

scholarly journals In VitroandIn VivoAntimalarial Evaluations of Myrtle Extract, a Plant Traditionally Used for Treatment of Parasitic Disorders

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Farzaneh Naghibi ◽  
Somayeh Esmaeili ◽  
Noor Rain Abdullah ◽  
Mehdi Nateghpour ◽  
Mahdieh Taghvai ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mammalian Cell ◽  
Methanolic Extract ◽  
Cytotoxic Activities ◽  
Traditional Use ◽  
Aerial Parts ◽  
Mammalian Cell Lines ◽  
Phytochemical Investigation

Based on the collected ethnobotanical data from the Traditional Medicine and Materia Medica Research Center (TMRC), Iran,Myrtus communisL. (myrtle) was selected for the assessment ofin vitroandin vivoantimalarial and cytotoxic activities. Methanolic extract of myrtle was prepared from the aerial parts and assessed for antiplasmodial activity, using the parasite lactate dehydrogenase (pLDH) assay against chloroquine-resistant (K1) and chloroquine-sensitive (3D7) strains ofPlasmodium falciparum. The 4-day suppressive test was employed to determine the parasitemia suppression of the myrtle extract againstP. berghei  in vivo. The IC50values of myrtle extract were 35.44 µg/ml against K1 and 0.87 µg/ml against 3D7. Myrtle extract showed a significant suppression of parasitaemia (84.8 ± 1.1% at 10 mg/kg/day) in mice infected withP. bergheiafter 4 days of treatment. Cytotoxic activity was carried out against mammalian cell lines using methyl thiazol tetrazolium (MTT) assay. No cytotoxic effect on mammalian cell lines up to 100 µg/mL was shown. The results support the traditional use of myrtle in malaria. Phytochemical investigation and understanding the mechanism of action would be in our upcoming project.

A Phytochemical Investigation of Erythroxylon australe F. Muell

1978 ◽  
Vol 31 (5) ◽  
pp. 1161 ◽  
Author(s):  
WJ Griffin
Keyword(s):  
Gas Chromatography ◽  
Spectral Analysis ◽  
Propionic Acid ◽  
Acid Moiety ◽  
Mass Spectral Analysis ◽  
Mass Spectral ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Phenyl Propionic Acid

(�)-6β,7β-Dihydroxytropan-3α-yl benzoate was isolated in low yield (0.001%) from the roots of Erythroxylon australe. The aerial parts were found to contain meteloidine (0.014%), (�)-6β-hydroxytropan-3α-yl tiglate (0.001%), (+)-3α-hydroxynortropan-6β-yl tiglate (0.002%) and an unknown base (0.003%) which was tentatively identified as (+)-7- hydroxy-6-tigloyloxynortropan-3-yl 2-hydroxy-3-phenylpropionate. The configuration of the unknown base was not determined. Structures were indicated by N.M.R. and mass spectral analysis and the phenyl propionic acid moiety identified by gas chromatography.

scholarly journals Phytochemical Constituents Identified from the Aerial Parts of Lespedeza cuneata and Their Effects on Lipid Metabolism during Adipocyte Maturation

Separations ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 203
Author(s):  
Heesun Kang ◽  
Minjeong Yoo ◽  
Sangah Yi ◽  
Taewan Kim ◽  
Jiwon Ha ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Lespedeza Cuneata ◽  
Gene Expressions ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Phytochemical Constituents ◽  
Regulate Lipid Metabolism

Lespedeza cuneata, belonging to Fabaceae, is well-known as Chinese bushclover, and it has been used in traditional folk medicines for the treatment of disorders, such as diabetes, hematuria, and insomnia. As part of continuing research projects to discover interesting natural compounds with biological activities from Korean medicinal plants, the phytochemical investigation of L. cuneata resulted in the isolation of five chemical constituents: α-tocopherol (1), 7a-methoxy-α-tocopherol (2), 13(R)-hydroxy-octadeca-(9Z,11E,15Z)-trien-oic acid (3), α-dimorphecolic acid (4), and lupeol (5). The structural determination of the isolated compounds was elucidated from data gathered through nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry (LC/MS). Until now, this study is the first to report these five compounds from the plant L. cuneata. Moreover, these isolated compounds (1–5) were evaluated for their anti-adipogenesis effects and their role in lipid metabolism during adipocyte maturation. As a result, the upregulation of mRNA expression levels of Fabp4 from 3T3-L1 pre-adipocytes treated with compounds 3 and 4 demonstrated that these compounds efficiently induced adipocyte differentiation. Furthermore, compounds 3 and 4 were found to regulate lipid metabolism by the induction of lipolytic and of lipogenic gene expressions. Therefore, experimental data from these findings supported that the compounds 3 and 4 induce the adipogenesis of 3T3-L1 pre-adipocytes and regulate lipid metabolism.

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