scholarly journals A proteolytic nanobiocatalyst with built-in disulphide reducing properties

RSC Advances ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 810-816
Author(s):  
Manon L. Briand ◽  
Maria Bikaki ◽  
Chasper Puorger ◽  
Philippe F.-X. Corvini ◽  
Patrick Shahgaldian
Keyword(s):  
Disulphide Bond ◽  
Reducing Properties

Proteolytic nanobiocatalysts are equipped with intrinsic disulphide bond reducing properties.

Cytotoxic, anti-radical and reducing properties of ethanol bark extracts of Geissospermum reticulatum

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
JJ Sajkowska-Kozielewicz ◽  
P Kozielewicz ◽  
NM Barnes ◽  
I Wawer ◽  
K Paradowska
Keyword(s):  
Reducing Properties

Mutations which Introduce Free Cysteine Residues in the Gla-Domain of Vitamin K Dependent Proteins Result in the Formation of Complexes with α1-Microglobulin

1996 ◽  
Vol 75 (01) ◽  
pp. 070-075 ◽  
Author(s):  
E G C Wojcik ◽  
P Simioni ◽  
M v d Berg ◽  
A Girolami ◽  
R M Bertina
Keyword(s):  
Vitamin K ◽  
Protein C ◽  
Cysteine Residue ◽  
Factor Ix ◽  
Disulphide Bond ◽  
Clotting Factors ◽  
High Molecular Weight Complex ◽  
Low Concentrations ◽  
Gla Domain ◽  
Formation Of Complexes

SummaryWe have previously described a genetic factor IX variant (Cys18→Arg) for which we demonstrated that it had formed a heterodimer with armicroglobulin through formation of a disulphide bond with the remaining free cysteine residue of the disrupted disulphide bond in the Gla-domain of factor IX. Recently, we observed a similar high molecular weight complex for a genetic protein C variant (Arg-1→Cys). Both the factor IX and the protein C variants have a defect in the calcium induced conformation. In this study we show that the aminoterminus of this protein C variant is prolonged with one amino acid, cysteine. This protein C variant, as well as protein C variants with Arg9→Cys and Ser12→Cys mutations which also carry a free cysteine residue, are shown to be present in plasma as a complex with α1-microglobulin. A prothrombin variant with a Tyr44→Cys mutation, had not formed such a complex. Furthermore, complexes between normal vitamin K-dependent clotting factors and α1-microglobulin were shown to be present in plasma at low concentrations. The data suggest that the presence of an unpaired cysteine residue in the propeptide or the N-terminal half of the Gla-domain has strongly promoted the formation of a complex with α1-microglobulin in the variants.

Multifunctional glycerol/citric acid crosslinked polymer hydrophilic gel with absorptive and reducing properties

2021 ◽  
Vol 45 (5) ◽  
pp. 2410-2416
Author(s):  
Fernanda G. Mendonça ◽  
Izadora R. S. Menezes ◽  
Ingrid F. Silva ◽  
Rochel M. Lago
Keyword(s):  
Citric Acid ◽  
Hybrid Gel ◽  
Crosslinked Polymer ◽  
The Matrix ◽  
Hydrophilic Gel ◽  
Reducing Properties

Multifunctional hydrogel based on glycerol/citric acid presents absorptive and reducing capacities, affording a hybrid gel containing AgNPs in the matrix.

scholarly journals Isoflavones Reduce Copper with Minimal Impact on IronIn Vitro

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Jana Karlíčková ◽  
Kateřina Macáková ◽  
Michal Říha ◽  
Liliane Maria Teixeira Pinheiro ◽  
Tomáš Filipský ◽  
...  
Keyword(s):  
Human Being ◽  
Asian Countries ◽  
Ferric Ions ◽  
Minimal Impact ◽  
Copper Absorption ◽  
Positive Effects ◽  
Reducing Properties

Isoflavones are commonly consumed in many Asian countries and have potentially positive effects on human being. Only a few and rather controversial data on their interactions with copper and iron are available to date. 13 structurally related isoflavones were tested in the competitive manner for their Cu/Fe-chelating/reducing properties. Notwithstanding the 5-hydroxy-4-keto chelation site was associated with ferric, ferrous, and cupric chelation, the chelation potential of isoflavones was low and no cuprous chelation was observed. None of isoflavones was able to substantially reduce ferric ions, but the vast majority reduced cupric ions. The most important feature for cupric reduction was the presence of an unsubstituted 4′-hydroxyl; contrarily the presence of a free 5-hydroxyl decreased or abolished the reduction due to chelation of cupric ions. The results from this study may enable additional experiments which might clarify the effects of isoflavones on human being and/or mechanisms of copper absorption.

Vibrio spp. secrete proaerolysin as a folded dimer without the need for disulphide bond formation

1995 ◽  
Vol 17 (6) ◽  
pp. 1035-1044 ◽  
Author(s):  
Kim R. Hardie ◽  
Angela Schulze ◽  
Michael W. Parker ◽  
J. Thomas Buckley
Keyword(s):  
Bond Formation ◽  
Disulphide Bond ◽  
Disulphide Bond Formation ◽  
Vibrio Spp

The uncertainty-reducing properties of achievement tasks revisited.

1984 ◽  
Vol 47 (4) ◽  
pp. 884-899 ◽  
Author(s):  
Richard M. Sorrentino ◽  
Erin C. Hewitt
Keyword(s):  
Reducing Properties
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