scholarly journals Superior anti-infective potential of eugenol–casein nanoparticles combined with polyethylene glycol against Colletotrichum musae infections

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4646-4653
Author(s):  
Xueyan Hao ◽  
Shuya Han ◽  
Dingkui Qin ◽  
Yahui Zhang ◽  
Peng Jin ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
The Stability ◽  
Colletotrichum Musae ◽  
Infective Potential

The aim of this study was to improve the stability of eugenol–casein nanoparticles (EL–CS-NPs) through polyethylene glycol (PEG) modification.

scholarly journals Buffer Additives and Packaging Differentially Influence the Stability of Dyes Commonly Used in Chromovitrectomy

2016 ◽  
Vol 1 (3) ◽  
pp. 1-10
Author(s):  
Begoña Parrado Aliod ◽  
Wilfried Kugler ◽  
Tim Häring
Keyword(s):  
Polyethylene Glycol ◽  
Chemical Stability ◽  
Deuterium Oxide ◽  
Oxidative Degradation ◽  
Bromophenol Blue ◽  
Physiological Range ◽  
Vis Spectroscopy ◽  
The Stability ◽  
Acid Violet ◽  
Dye Solutions

Purpose: This study was performed to investigate the chemical stability of different dyes used in chromovitrectomy and the influence of various product parameters on it. Methods: Buffered dye solutions were prepared containing 1.5 g/L acid violet 17, 0.25 g/L brilliant blue G, 1.3 g/L bromophenol blue, and 1.5 g/L trypan blue, combined with deuterium oxide, polyethylene glycol 3350, and D-mannitol as additives. For accelerated storage testing, samples were incubated for 400 h at 80°C corresponding to 2 years according to the Van ‘t Hoff equation. After different incubation times samples were taken for UV/Vis spectroscopy, pH measurement, and osmometry. Results: Depending on dye, additive, and packaging, different solutions exhibit differences in chemical stability and hence shelf life. Packaging in syringes instead of vials increases dye stability. Additives may negatively influence important parameters, e.g. polyethylene glycol 3350 increases osmolality beyond the physiological range. Notably, acid violet 17 is chemically unstable except in D-mannitol-containing buffer, packed in syringes. However, simultaneously, D-mannitol leads to a pH shift below 7.0. Conclusion: In summary, dye solutions filled in syringes should be preferred to vials to slow down oxidative degradation. Especially acid violet 17 solutions should be used with caution because the addition of D-mannitol may contribute to pH values beyond the physiological range.

scholarly journals Modifications of proteins of membrane-cytoskeleton complex and production of reactive oxygen species in erythrocytes cryopreserved with polyethylene glycol

2021 ◽  
Vol 67 (2) ◽  
pp. 44-52
Author(s):  
N.G. Zemlianskykh ◽  
◽  
L.O. Babiychuk ◽  
Keyword(s):  
Reactive Oxygen Species ◽  
Polyethylene Glycol ◽  
Protein Profile ◽  
Control Level ◽  
Reactive Oxygen ◽  
Fold Increase ◽  
Oxygen Species ◽  
Membrane Cytoskeleton ◽  
Extreme Factors ◽  
The Stability

Protein modifications in the membrane-cytoskeleton complex (MCC) of human erythrocytes, as well as changes in the intensity of reactive oxygen species (ROS) production upon cell cryopreservation with polyethylene glycol (PEG) were investigated. The protein profile of ghosts of erythrocytes frozen with PEG has common features with both the control and cells frozen without cryoprotectant. PEG makes it possible to restrict the structural rearrangements of the main MCC proteins under the effect of extreme factors and to restrain the amount of high molecular weight polypeptide complexes induced by the protein-cross-linking reagent diamide at the control level, in contrast to cells frozen without a cryoprotectant. However, changes related to the protein peroxiredoxin 2 in ghosts of erythrocytes cryopreserved with PEG are also attributed to cells frozen without a cryoprotectant that may be associated with the activation of oxidative processes. This is evidenced by a 10-fold increase in ROS formation in erythrocytes frozen under PEG protection. Thus, upon cryopreservation of erythrocytes with PEG, certain disorders in MCC proteins may be associated with increased formation of ROS, which may contribute to the disorganization of the structural components of MCC and disrupt the stability of cryopreserved cells under physiological conditions.

scholarly journals SYNTHESIS AND STABILITY OF RESVERATROL-CONJUGATED GOLD NANOPARTICLES MODIFIED WITH POLYETHYLENE GLYCOL

2020 ◽  
pp. 230-236
Author(s):  
RADITYA ISWANDANA ◽  
RICHA NURSELVIANA ◽  
SUTRIYO SUTRIYO
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Zeta Potential ◽  
High Performance ◽  
Entrapment Efficiency ◽  
Test Results ◽  
Novel Method ◽  
The Stability ◽  
Phosphate Buffered Saline

Objective: Gold nanoparticles (AuNPs) are highly useful for drug delivery, but their application is limited by their stability as they readily aggregate.This issue can be prevented by adding a stabilizing agent such as resveratrol (RSV), which is a polyphenol derived from plants, that is used to preventcancer. Therefore, we propose a novel method to prepare stable RSV-conjugated nanoparticles modified with polyethylene glycol (RSV-AuNP-PEG).Methods: In the first step, the Turkevich method was used to synthesize the AuNPs. Then, PEG was added as stabilizer agent and conjugated with RSV.The synthesized conjugates were characterized using ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, particle sizeanalysis, and high-performance liquid chromatography.Results: The obtained RSV-AuNP-PEG had a particle size of 83.93 nm with a polydispersity index (PDI) of 0.562 and formed a translucent purple-redfluid in solution. The zeta potential was −22.9 mV, and the highest entrapment efficiency was 75.86±0.66%. For comparison, the RSV-AuNP solutionwas purple and turbid, the particle size was 51.97 nm with a PDI of 0.694, and the zeta potential was −24.6 mV. The stability test results showed thatthe storage stability of RSV-AuNP-PEG was better than that of AuNP-RSV. Further, the RSV-AuNP-PEG was shown to be most stable in 2% bovine serumalbumin (BSA) while the AuNP-RSV was most stable in 2% BSA in phosphate-buffered saline pH 7.4.Conclusion: These results show that modification of RSV-conjugated AuNPs with PEG effectively prevents their aggregation in storage, but only incertain mediums.

scholarly journals Silk fibroin/polyethylene glycol nanofibrous membranes loaded with curcumin

2017 ◽  
Vol 21 (4) ◽  
pp. 1587-1594 ◽  
Author(s):  
Qing Liu ◽  
Shufa Zhou ◽  
Zeyu Zhao ◽  
Ting Wu ◽  
Rong Wang ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Silk Fibroin ◽  
Drug Loading ◽  
Control Drug ◽  
Nanofiber Membranes ◽  
Utilization Ratio ◽  
The Stability ◽  
Control Drug Release

In order to improve the stability, utilization ratio and anti-tumor effect of curcumin drug, a set of curcumin-loaded nanofiber membranes with drug releasing property were fabricated using silk fibroin and polyethylene glycol. Various curcumin-loaded silk fibroin nanofiber membranes with different components and drug loading percentages were prepared using electrospinning technology. The morphology structure, mechanical properties, secondary structure, drug release property in vitro, and their interaction effects of the curcumin-loaded silk fibroin nanofiber membranes were examined. The result of in-vitro drug release experiment showed that the curcumin can be released stably up to 350 hours, the drug releasing speed increased with the decrease of the diameter of the fibers. The stability and utilization ratio of curcumin was improved after loading with curcumin-loaded silk fibroin nanofiber membranes. In conclusion, it can be used as a control drug release system alternately in the future.

Study on Influence of Polyethylene Glycol on Dispersion of Pyrite Powder in Aqueous Solution

2012 ◽  
Vol 554-556 ◽  
pp. 349-352
Author(s):  
Dan Li ◽  
Zhou Lan Yin ◽  
Qi Yuan Chen
Keyword(s):  
Aqueous Solution ◽  
Hydrogen Bonding ◽  
Polyethylene Glycol ◽  
Spectroscopic Analysis ◽  
Ph Value ◽  
Aqueous Suspension ◽  
Dispersion Stability ◽  
The Stability ◽  
High Degree ◽  
Effective Additive

The influences of three kinds of polyethylene glycol (PEG), namely PEG-200, PEG-1000 and PEG-20000, on the dispersion stability of pyrite powder in aqueous solution were investigated by spectrophotometry. The results indicated that the stability of pyrite powder dispersed in aqueous solution was remarkably dependent upon the molecular weight and content of PEG, pH value of suspension, and ultrasonication power. Among three kinds of polyethylene glycol, PEG-20000 was the most effective additive to improve the dispersion stability and wettability of pyrite powder in water. When 8% PEG-20000 was employed as the dispersant, the best dispersion stability of pyrite powder in aqueous solution could be obtained under the conditions of pH at 5-6 and 100-W ultrasonication power. The FTIR spectroscopic analysis showed that the adsorption between the polyethylene glycol and pyrite ore powder was formed by hydrogen bonding. The adsorption of polyethylene glycol onto the surface of pyrite powder via hydrogen bonding provided a high degree of steric stabilization, which effectively prohibited the aggregation of pyrite powder, and thus the dispersion stability of as-formed aqueous suspension was promoted.

scholarly journals Comparative study of the stability of free and modified papain incorporated in topical formulations

2011 ◽  
Vol 47 (4) ◽  
pp. 751-760 ◽  
Author(s):  
Claudinéia Aparecida Sales de Oliveira Pinto ◽  
Patricia Santos Lopes ◽  
Fernanda Daud Sarruf ◽  
Bronislaw Polakiewicz ◽  
Telma Mary Kaneko ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Comparative Study ◽  
Suitable Condition ◽  
Stability Testing ◽  
Active Compounds ◽  
Topical Formulations ◽  
Temperature Conditions ◽  
Chemical Peeling ◽  
Normal Stability ◽  
The Stability

Papain is an enzyme used in topical formulations as a proteolytic debriding agent for the treatment of open, extensive wounds and burnings. It is also employed as an enhancer for cutaneous permeation of active compounds, chemical peeling and as a progressive depilatory agent. The stability of formulations containing enzymes is not easy. In this research, papain was modified with polyethylene glycol in order to increase the stability of the formulations. The comparative Normal Stability Testing of the topical formulations containing unmodified and modified papain showed that the modified variety presented with a differentiated profile under the adopted temperature conditions (5.0 ± 1.0 °C; 22.0 ± 2.0 °C; 40.0 ± 2.0 °C). The most suitable condition for non-modified papain were 5.0 ± 1.0 °C and, for modified papain, they were 22.0 ± 2.0 °C. These results confirmed the higher stability of modified papain compared to free papain, as well as its potential to be applied in topical formulations.

Influence of HLB Parameters of Surfactants on Properties of Magneto-Rheological Fluid

2010 ◽  
Vol 97-101 ◽  
pp. 843-847 ◽  
Author(s):  
Cheng Bin Du ◽  
Wei Qing Chen ◽  
Fa Xue Wan
Keyword(s):  
Magnetic Properties ◽  
Oleic Acid ◽  
Polyethylene Glycol ◽  
Rheological Properties ◽  
Magnetic Particles ◽  
Hydrophilic Lipophilic Balance ◽  
The Stability ◽  
Magneto Rheological

The hydrophilic-lipophilic balance (HLB) parameters of surfactants have a significant effect on properties of surfactants and determine the effects of surfactants. The magneto-rheological fluid (MRF) is prepared by using the two typical HLB parameters of surfactants including Polyethylene Glycol and oleic acid in order to improve the property of MRF. Polyethylene Glycol (PEG) whose HLB parameter is 20 has strong hydrophilic. Oleic acid whose HLB parameter is 1 has strong lipophilic. The results indicate that magnetic properties of magnetic particles and rheological properties of MRF can hardly be changed by adding surfactants. The sedimentary stability of MRF adding lipophilic surfactants is superior to that of MRF adding hydrophilic surfactants, and the stability of MRF adding two surfactants increases significantly.

Co-Encapsulation of Lycopene and Resveratrol in Polymeric Nanoparticles: Morphology and Lycopene Stability

2021 ◽  
Vol 21 (5) ◽  
pp. 3156-3164
Author(s):  
Ho Thi Oanh ◽  
Nhung Hac Thi ◽  
Thanh Nhan Nguyen ◽  
Tuyet Anh Dang Thi ◽  
Tuyen Van Nguyen ◽  
...  
Keyword(s):  
Particle Size ◽  
Polyethylene Glycol ◽  
Vitamin E ◽  
Polymeric Nanoparticles ◽  
Antioxidant Properties ◽  
Total Content ◽  
Butylated Hydroxytoluene ◽  
Average Particle ◽  
Lycopene Content ◽  
The Stability

Lycopene and resveratrol are well-known for their high bioactivity, anti-inflammatory effects, and strong antioxidant properties. The combination of lycopene and resveratrol was synergistic in the potentializing immunity of the mammal body. In this study, the scalable co-encapsulation of lycopene and resveratrol into polymeric nanoparticles was performed using lycopene extracted from ripe gac fruit. These nanoparticles exhibited excellent water dispersion and spherical morphology with average particle diameters of 66.102 nm. The particle size was proportional to the lycopene/resveratrol ratio. The combinative use of lecithin and Tween® as surfactants and the use of a polylactide-polyethylene glycol copolymer as an encapsulation agent generated well-defined lycopene/resveratrol nanoparticles although the total content of these active compounds reached 12%. The stability of lycopene was enhanced when combined with resveratrol and antioxidants such as vitamin E and butylated hydroxytoluene. After 3 months of storage at −16 °C, the lycopene content in the lycopene/resveratrol nanopowder remained at ∼95%.

Influence of ZnO Powders on the Stability of the Foams Stabilized by Surfactants

2013 ◽  
Vol 785-786 ◽  
pp. 359-364 ◽  
Author(s):  
Chen Chen ◽  
Zhi Rong Ren ◽  
Juan He ◽  
Yong Jun He
Keyword(s):  
Polyethylene Glycol ◽  
Synergistic Effect ◽  
Sodium Dodecyl ◽  
Phenyl Ether ◽  
Ammonium Bromide ◽  
Unstable System ◽  
Stabilizing Effect ◽  
Zno Powders ◽  
The Stability ◽  
Triton X

Foam is a thermodynamically unstable system, and the stability is the most important factor for the preparation and application of foams. In this paper, the effect of ZnO powders on the stability of the foams stabilized by sodium dodecyl benzene sulphonate (SDBS), hexadecyl trimethyl ammonium bromide (CTAB) and Polyethylene glycol tertoctyl phenyl ether (TritonX-100) was investigated. The results showed that ZnO powders have a synergistic effect with SDBS and CTAB. There is no synergy between ZnO powders and Triton X-100. The mechanism for the stabilizing effect of ZnO powders on the foams was discussed.

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