scholarly journals Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis

RSC Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 3567-3574
Author(s):  
Xiangyu Li ◽  
Yufei Hou ◽  
Xiangxue Meng ◽  
Ge Li ◽  
Fei Xu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Folate Receptor ◽  
Gold Nanorod ◽  
Receptor Targeting ◽  
Targeted Nanoparticles ◽  
Folate Receptor Targeting

The use of targeted nanoparticles MTX-FAGMs in combined NIR-induced PTT and traditional chemotherapy has potential as a desirable nanopharmaceuticals platform for the treatment of RA.

scholarly journals Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

2017 ◽  
Vol Volume 12 ◽  
pp. 6735-6746 ◽  
Author(s):  
Jinlong Zhao ◽  
Menghui Zhao ◽  
Changhui Yu ◽  
Xueyan Zhang ◽  
Jiaxin Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folate Receptor ◽  
Ph Responsive ◽  
Receptor Targeting ◽  
Folate Receptor Targeting

Radiosynthesis and Preclinical Evaluation of 3′-Aza-2′-[18F]fluorofolic Acid: A Novel PET Radiotracer for Folate Receptor Targeting

2013 ◽  
Vol 24 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Thomas Betzel ◽  
Cristina Müller ◽  
Viola Groehn ◽  
Adrienne Müller ◽  
Josefine Reber ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Receptor Targeting ◽  
Preclinical Evaluation ◽  
Folate Receptor Targeting

scholarly journals Tumor imaging using P866, a high-relaxivity gadolinium chelate designed for folate receptor targeting

2008 ◽  
Vol 60 (6) ◽  
pp. 1337-1346 ◽  
Author(s):  
Claire Corot ◽  
Philippe Robert ◽  
Eric Lancelot ◽  
Philippe Prigent ◽  
Sébastien Ballet ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Folate Receptor ◽  
Receptor Targeting ◽  
Gadolinium Chelate ◽  
High Relaxivity ◽  
Folate Receptor Targeting

scholarly journals Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Kumi Kawano ◽  
Yoshie Maitani
Keyword(s):  
Polyethylene Glycol ◽  
Liposomal Doxorubicin ◽  
Folate Receptor ◽  
In Vitro Cytotoxicity ◽  
Receptor Targeting ◽  
Spacer Length ◽  
Ligand Density ◽  
Molecular Weights ◽  
Folate Receptor Targeting

The folate receptor is an attractive target for selective tumor delivery of liposomal doxorubicin (DXR) because it is abundantly expressed in a large percentage of tumors. This study examined the effect of polyethylene glycol (PEG) spacer length and folate ligand density on the targeting ability of folate-modified liposomes. Liposomes were modified with folate-derivatized PEG-distearoylphosphatidylethanolamine with PEG molecular weights of 2000, 3400, or 5000. The association of DXR-loaded liposomes with KB cells, which overexpress the folate receptor, was evaluated by flow cytometry at various ratios of folate modification. A low ratio of folate modification with a sufficiently long PEG chain showed the highest folate receptor-mediated association with the cells, but did not show the highest in vitro cytotoxicity. DXR release from folate-modified liposomes in endosomes might be different. These findings will be useful for designing folate receptor-targeting carriers.

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