scholarly journals In vitro and in vivo evaluation of folate receptor-targeting amphiphilic copolymer-modified liposomes loaded with docetaxel

2011 ◽  
pp. 1167 ◽  
Author(s):  
Weisan Pan ◽  
Li ◽  
Tian ◽  
Zhang ◽  
Zhao ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Amphiphilic Copolymer ◽  
In Vivo Evaluation ◽  
Receptor Targeting ◽  
Folate Receptor Targeting

Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation

2016 ◽  
Vol 500 (1-2) ◽  
pp. 162-178 ◽  
Author(s):  
Mona Alibolandi ◽  
Khalil Abnous ◽  
Fatemeh Sadeghi ◽  
Hossein Hosseinkhani ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Folate Receptor ◽  
Breast Adenocarcinoma ◽  
In Vivo Evaluation

scholarly journals Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Kumi Kawano ◽  
Yoshie Maitani
Keyword(s):  
Polyethylene Glycol ◽  
Liposomal Doxorubicin ◽  
Folate Receptor ◽  
In Vitro Cytotoxicity ◽  
Receptor Targeting ◽  
Spacer Length ◽  
Ligand Density ◽  
Molecular Weights ◽  
Folate Receptor Targeting

The folate receptor is an attractive target for selective tumor delivery of liposomal doxorubicin (DXR) because it is abundantly expressed in a large percentage of tumors. This study examined the effect of polyethylene glycol (PEG) spacer length and folate ligand density on the targeting ability of folate-modified liposomes. Liposomes were modified with folate-derivatized PEG-distearoylphosphatidylethanolamine with PEG molecular weights of 2000, 3400, or 5000. The association of DXR-loaded liposomes with KB cells, which overexpress the folate receptor, was evaluated by flow cytometry at various ratios of folate modification. A low ratio of folate modification with a sufficiently long PEG chain showed the highest folate receptor-mediated association with the cells, but did not show the highest in vitro cytotoxicity. DXR release from folate-modified liposomes in endosomes might be different. These findings will be useful for designing folate receptor-targeting carriers.

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

2012 ◽  
Vol 23 (4) ◽  
pp. 805-813 ◽  
Author(s):  
Cindy R. Fischer ◽  
Cristina Müller ◽  
Josefine Reber ◽  
Adrienne Müller ◽  
Stefanie D. Krämer ◽  
...  
Keyword(s):  
Folate Receptor ◽  
Receptor Targeting ◽  
Folate Receptor Targeting

scholarly journals Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 1182-1191 ◽  
Author(s):  
Nan Zhang ◽  
Chunyu Xu ◽  
Na Li ◽  
Shasha Zhang ◽  
Lingling Fu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Folate Receptor ◽  
Polysialic Acid ◽  
In Vivo Evaluation
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