scholarly journals Recent progress in transition-metal-free functionalization of allenamides

RSC Advances ◽  
2020 ◽  
Vol 10 (60) ◽  
pp. 36818-36827
Author(s):  
Xiaoxiao Li ◽  
Yongchun Liu ◽  
Na Ding ◽  
Xiaoju Tan ◽  
Zhigang Zhao
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Complex Molecules ◽  
Metal Free ◽  
Powerful Approach

Recent progress in transition-metal-free functionalization of allenamides is reviewed, providing a powerful approach to rapidly access complex molecules.

Metal-Free Catalytic Aromatic C–H Borylation

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1857-1861
Author(s):  
Hua Zhang ◽  
Li Wang
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Rapid Development ◽  
Transition Metal Catalysis ◽  
Mechanistic Studies ◽  
Metal Catalysis ◽  
Promising Alternative ◽  
Metal Free ◽  
History Of ◽  
Near Future

In recent decades, C–H borylation has undergone rapid development and has become one of the most important and efficient methods for the synthesis of organoboron compounds. Although transition-metal catalysis dominates C–H borylation, the metal-free approach has emerged as a promising alternative strategy. This article briefly summarizes the history of metal-free aromatic C–H borylation, including early reports on electrophilic C–H borylation and recent progress in metal-free catalytic intermolecular C–H borylation; it also highlights our recent work on BF3·Et2O-catalyzed C2–H borylation of hetarenes. Despite these recent advances, comprehensive mechanistic studies on various metal-free catalytic aromatic C–H borylations and novel processes with a wider substrate scope are eagerly expected in the near future.

Uncovering Multifaceted Iodonium Ylides: Versatile Reactivity Enables Cyclization of Simple Arylamines

Synlett ◽  
2018 ◽  
Vol 29 (18) ◽  
pp. 2337-2341 ◽  
Author(s):  
Yao Wang ◽  
Liang Zhang
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Chemical Properties ◽  
Historical Background ◽  
Chemical Transformations ◽  
Metal Free ◽  
Reaction Discovery ◽  
Iodonium Ylides

Iodonium ylides can undergo cyclization with a simple tertiary arylamine to afford N-heterocyclic products in a transition-metal-free approach in the absence of an additional initiator/oxidant. The ­inherent reactivity uncovered in this transformation is fundamentally different from known chemical properties of iodonium ylide compounds, thus providing a new opportunity for the further exploration of iodonium ylide-based chemical transformations. This Synpacts article describes the historical background of iodonium ylide chemistry and highlights recent progress disclosed by our work.1 Introduction2 The Strategy for New Reaction Discovery3 Application to Cyclization of Tertiary Arylamines4 Conclusion and Perspectives

scholarly journals Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes

2021 ◽  
Vol 17 ◽  
pp. 551-557
Author(s):  
Xiaojuan Li ◽  
Qiang Zhang ◽  
Weigang Zhang ◽  
Jinzhu Ma ◽  
Yi Wang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Complex Molecules ◽  
Radical Process ◽  
Metal Free ◽  
Mild Conditions

The difunctionalization of alkenes involving a trifluoromethylthio group (SCF3) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transition-metal-free protocol is presented for the vicinal trifluoromethylthio–thiolation of unactivated alkenes via a radical process under mild conditions with a broad substrate scope and excellent tolerance.

scholarly journals Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes

2021 ◽  
Author(s):  
Xiaojuan Li ◽  
Qiang Zhang ◽  
Weigang Zhang ◽  
Jinzhu Ma ◽  
Yi Wang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Mild Condition ◽  
Complex Molecules ◽  
Radical Process ◽  
Metal Free

The difunctionalization of alkenes involving trifluoromethylthio group (SCF3) for the conversion of versatile and readily available olefins into more structurally complex molecules has been greatly studied. However, the disproportionate dithiolation of alkene is unknown. Herein, a transition-metal-free protocol is presented for vicinal trifluoromethylthio-thiolation of unactivated alkenes via a radical process under mild condition with broad substrate scope and excellent tolerance.

Recent Progress in Amination Enabled by Transition-Metal-Free C(sp2)–O/C(sp2)–S Bond Cleavage Strategy

Synthesis ◽  
2021 ◽  
Author(s):  
Xin-Ge Yang ◽  
Xue-Qiang Wang ◽  
Shen-Huan Li ◽  
Cheng-Yu Long
Keyword(s):  
Transition Metal ◽  
Natural Product ◽  
Aromatic Amines ◽  
Recent Progress ◽  
Bond Cleavage ◽  
Metal Free ◽  
Complementary Methods ◽  
The Past ◽  
Recent Advances ◽  
Metal Catalyzed

AbstractRecently, intense efforts have been dedicated to the development of novel synthetic strategies to access aromatic amines due to their importance in the pharmaceuticals, agrochemicals, materials, and natural product areas. Although numerous transition-metal-catalyzed C–N formation strategies have been described for the preparation of aromatic amines in the past few decades, complementary methods under transition-metal-free conditions are still required. We present the recent advances in the exploration of innovative amination approaches via C(sp2)–O/C(sp2)–S bond cleavage in this review.1 Introduction2 Stoichiometric Base-Promoted Amination3 Base-Catalyzed Amination4 Photoredox-Catalyzed Amination5 Acid-Promoted Amination6 Conclusion and Perspectives

scholarly journals Recent Progress Concerning the N-arylation of Indoles

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5079
Author(s):  
Petr Oeser ◽  
Jakub Koudelka ◽  
Artem Petrenko ◽  
Tomáš Tobrman
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Final Section ◽  
State Of The Art ◽  
Biologically Active ◽  
Short Introduction ◽  
Metal Free ◽  
Current State ◽  
Palladium Catalyzed

This review summarizes the current state-of-the-art procedures in terms of the preparation of N-arylindoles. After a short introduction, the transition-metal-free procedures available for the N-arylation of indoles are briefly discussed. Then, the nickel-catalyzed and palladium-catalyzed N-arylation of indoles are both discussed. In the next section, copper-catalyzed procedures for the N-arylation of indoles are described. The final section focuses on recent findings in the field of biologically active N-arylindoles.

Transition-metal-free catalytic hydroboration reduction of amides to amines

2020 ◽  
Vol 7 (21) ◽  
pp. 3515-3520
Author(s):  
Wubing Yao ◽  
Jiali Wang ◽  
Aiguo Zhong ◽  
Shiliang Wang ◽  
Yinlin Shao
Keyword(s):  
Transition Metal ◽  
Selective Catalytic Reduction ◽  
Catalytic Reduction ◽  
Value Added ◽  
Metal Free

The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

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