scholarly journals One-pot synthesis of indoles and quinolinones from ortho-tosylaminophenyl-substituted para-quinone methides

RSC Advances ◽  
2020 ◽  
Vol 10 (55) ◽  
pp. 33455-33460
Author(s):  
Junwei Wang ◽  
Xiang Pan ◽  
Quanjin Rong ◽  
Lei Zhao ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Conjugate Addition ◽  
Quinone Methides ◽  
One Pot ◽  
One Pot Synthesis

A facile one-pot synthesis has been developed through alkylation/acylation of ortho-tosylaminophenyl-substituted para-quinone methides followed by an intramolecular 1,6-conjugate addition and oxidation sequence.

1,6-Conjugate addition initiated formal [4+2] annulation of p-quinone methides with sulfonyl allenols: a unique access to spiro[5.5]undeca-1,4-dien-3-one scaffolds

2020 ◽  
Vol 56 (37) ◽  
pp. 5022-5025 ◽  
Author(s):  
Ganesh S. Ghotekar ◽  
Sachin R. Shirsath ◽  
Aslam C. Shaikh ◽  
M. Muthukrishnan
Keyword(s):  
Conjugate Addition ◽  
Quinone Methides ◽  
One Pot ◽  
One Pot Synthesis

An expedient one-pot synthesis of carbocyclic spiro[5.5]undeca-1,4-dien-3-ones via 1,6-conjugate addition initiated formal [4+2] annulation sequences by employing p-quinone methides and sulfonyl allenols.

scholarly journals Tandem Fries Reaction–Conjugate Addition under Microwave Irradiation in Dry Media; One-pot Synthesis of Flavanones

1999 ◽  
Vol 23 (9) ◽  
pp. 574-575
Author(s):  
Firouz Matloubi Moghaddam ◽  
Mohammad Ghaffarzadeh ◽  
Seyed Hossein Abdi-Oskoui
Keyword(s):  
Microwave Irradiation ◽  
Silica Gel ◽  
Conjugate Addition ◽  
Solvent Free ◽  
Naphthalene Derivatives ◽  
One Pot ◽  
Fries Rearrangement ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Fries Reaction

An AICl3–ZnCl2 mixture supported on silica gel is found to be an efficient medium for the Fries rearrangement of acyloxybenzene or naphthalene derivatives in solvent-free conditions under microwave irradiation.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

Conjugate addition of isocyanides to chromone 3-carboxylic acid: an efficient one-pot synthesis of chroman-4-one 2-carboxamides

2012 ◽  
Vol 10 (17) ◽  
pp. 3406 ◽  
Author(s):  
Ana G. Neo ◽  
Jesús Díaz ◽  
Stefano Marcaccini ◽  
Carlos F. Marcos
Keyword(s):  
Carboxylic Acid ◽  
Conjugate Addition ◽  
One Pot ◽  
One Pot Synthesis

Highly Selective One-Pot Synthesis of Polysubstituted Isoflavanes using Styryl Ethers and Electron-Withdrawing ortho-Quinone Methides Generated In Situ

Synlett ◽  
2018 ◽  
Vol 30 (02) ◽  
pp. 189-192 ◽  
Author(s):  
Yujiro Hoshino ◽  
Kiyoshi Honda ◽  
Kenta Tanaka ◽  
Mami Kishimoto ◽  
Naoya Ohtsuka ◽  
...  
Keyword(s):  
Biologically Active ◽  
Quinone Methides ◽  
One Pot ◽  
One Pot Synthesis ◽  
Reaction Proceeds ◽  
Acidic Conditions ◽  
High Yields

A highly selective one-pot synthesis of polysubstituted isoflavanes has been developed. The reaction proceeds through the cycloaddition of methyl styryl ethers, derived from phenylacetaldehyde dimethyl acetals under acidic conditions, with electron-withdrawing ortho-quinone methides generated in situ. When phenylacetaldehyde dimethyl acetals were reacted with salicylaldehydes, the reaction proceeded smoothly to afford the corresponding isoflavanes stereoselectively in high yields and with excellent regioselectivities. The present reaction provides versatile access to functionalized isoflavanes, and constitutes a useful tool for the synthesis of biologically active molecules.

Electrochemically Initiated Tandem and Sequential Conjugate Addition Processes: One-Pot Synthesis of Diverse Functionalized Isoindolinones

2012 ◽  
Vol 354 (9) ◽  
pp. 1717-1724 ◽  
Author(s):  
Pasqualmorica Antico ◽  
Vito Capaccio ◽  
Antonia Di Mola ◽  
Antonio Massa ◽  
Laura Palombi
Keyword(s):  
Conjugate Addition ◽  
One Pot ◽  
One Pot Synthesis

Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides

2015 ◽  
Vol 51 (87) ◽  
pp. 15831-15834 ◽  
Author(s):  
Kuo Gai ◽  
Xinxin Fang ◽  
Xuanyi Li ◽  
Jinyi Xu ◽  
Xiaoming Wu ◽  
...  
Keyword(s):  
Conjugate Addition ◽  
Quinone Methides ◽  
One Pot ◽  
Quaternary Centers

Spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers was synthesized in one pot without the use of metals.

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