scholarly journals Fabrication of paper microfluidic devices using a toner laser printer

RSC Advances ◽  
2020 ◽  
Vol 10 (50) ◽  
pp. 29797-29807 ◽  
Author(s):  
James S. Ng ◽  
Michinao Hashimoto
Keyword(s):  
Potential Problem ◽  
Microfluidic Devices ◽  
Laser Printer ◽  
Long Duration ◽  
Paper Microfluidic ◽  
Duration Of Heating

We developed a method to fabricate microfluidic paper-based analytical devices (μPADs) using a toner laser printer. We addressed a potential problem of pyrolysis that resulted from long duration of heating required for the penetration of the toner.

scholarly journals Using printer ink color to control the behavior of paper microfluidics

Lab on a Chip ◽  
2019 ◽  
Vol 19 (11) ◽  
pp. 2000-2008 ◽  
Author(s):  
Joshua Potter ◽  
Philip Brisk ◽  
William H. Grover
Keyword(s):  
Microfluidic Devices ◽  
Paper Microfluidics ◽  
Paper Microfluidic

Different colors of wax inks behave differently in paper microfluidic devices, enabling the development of new color-based paper microfluidic components.

scholarly journals Citizen-Led Sampling to Monitor Phosphate Levels in Freshwater Environments Using a Simple Paper Microfluidic Device

2021 ◽  
Author(s):  
Samantha Richardson ◽  
Alexander Iles ◽  
Jeanette M. Rotchell ◽  
Tim Charlson ◽  
Annabel Hanson ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Mobile Technology ◽  
High Frequency ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Smartphone App ◽  
Test Device ◽  
Monitoring Campaign ◽  
Paper Microfluidic ◽  
Freshwater Environments

We demonstrate how a combination of paper microfluidic devices and handheld mobile technology can be used by citizen scientists to carry out a sustained water monitoring campaign. We have developed a paper-based analysis device and a 3 minute sampling workflow that requires no more than a container, a test device and a smartphone app. The contaminant measured in these pilots are phosphates, detectable down to 3 mg L<sup>-1</sup>. Together these allow volunteers to successfully carry out cost-effective, high frequency, phosphate monitoring over an extended geographies and periods.

scholarly journals Modelling-Guided Design of Paper Microfluidic Networks – A Case Study of Sequential Fluid Delivery

2020 ◽  
Author(s):  
Dharitri Rath ◽  
Bhushan Toley
Keyword(s):  
Mathematical Models ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Computational Design ◽  
Engineering Problem ◽  
Richards Equation ◽  
Trial And Error ◽  
Microfluidic Networks ◽  
Paper Microfluidic ◽  
Flow Through

<p>Paper-based microfluidic devices are popular for their ability to automate multi-step assays for chemical or biological sensing at a low cost, but the design of paper microfluidic networks has largely relied on experimental trial and error. A few mathematical models of flow through paper microfluidic devices have been developed and have succeeded in explaining experimental flow behaviour. However, the reverse engineering problem of designing complex paper networks guided by appropriate mathematical models is largely unsolved. In this article, we demonstrate that a two-dimensional paper network (2DPN) designed to sequentially deliver three fluids to a test zone on the device can be computationally designed and experimentally implemented without trial and error. This was accomplished by three new developments in modelling flow through paper networks: i) coupling of the Richards equation of flow through porous media to the species transport equation, ii) modelling flow through assemblies of multiple paper materials (test membrane and wicking pad), and iii) incorporating limited-volume fluid sources. We demonstrate the application of this model in the optimal design of a paper-based signal-enhanced immunoassay for a malaria protein, P<i>f</i>HRP2. This work lays the foundation for the development of a computational design toolbox to aid in the design of paper microfluidic networks.</p>

Colorimetric analysis of the decomposition of S-nitrosothiols on paper-based microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (22) ◽  
pp. 6314-6320 ◽  
Author(s):  
Abdulghani Ismail ◽  
Marillya O. Araújo ◽  
Cyro L. S. Chagas ◽  
Sophie Griveau ◽  
Fanny D'Orlyé ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Colorimetric Analysis ◽  
Paper Microfluidic

A disposable paper microfluidic device was developed to analyse different S-nitrosothiols simultaneously decomposed by Hg2+ as well as UV, Vis and IR lamps.

Highly sensitive colorimetric detection of glucose and uric acid in biological fluids using chitosan-modified paper microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (15) ◽  
pp. 4749-4756 ◽  
Author(s):  
Ellen F. M. Gabriel ◽  
Paulo T. Garcia ◽  
Thiago M. G. Cardoso ◽  
Flavio M. Lopes ◽  
Felipe T. Martins ◽  
...  
Keyword(s):  
Uric Acid ◽  
Biological Fluids ◽  
Colorimetric Detection ◽  
Microfluidic Devices ◽  
Analytical Performance ◽  
Highly Sensitive ◽  
Colorimetric Measurements ◽  
Paper Microfluidic ◽  
Enzymatic Bioassays

This paper describes the modification of microfluidic paper-based analytical devices (μPADs) with chitosan to improve the analytical performance of colorimetric measurements associated with enzymatic bioassays.

A simple cantilever system for measurement of flow rates in paper microfluidic devices

2019 ◽  
Vol 1 (2) ◽  
pp. 025019
Author(s):  
Omar Mohd ◽  
Mohamad S Sotoudegan ◽  
Frances S Ligler ◽  
Glenn M Walker
Keyword(s):  
Microfluidic Devices ◽  
Flow Rates ◽  
Paper Microfluidic

scholarly journals Correction: The development of paper microfluidic devices for presumptive drug detection

2015 ◽  
Vol 7 (20) ◽  
pp. 8977-8977
Author(s):  
Giacomo Musile ◽  
Ling Wang ◽  
Jashaun Bottoms ◽  
Franco Tagliaro ◽  
Bruce McCord
Keyword(s):  
Microfluidic Devices ◽  
Drug Detection ◽  
Paper Microfluidic

Correction for ‘The development of paper microfluidic devices for presumptive drug detection’ by Giacomo Musile et al., Anal. Methods, 2015, DOI: 10.1039/c5ay01432h.

Optimized short digestion protocol for free fetal DNA detection using methylation-dependent markers

2017 ◽  
Vol 41 (4) ◽  
Author(s):  
Ana B. Rodríguez-Martínez ◽  
Esther Sarasola-Díez ◽  
Estíbaliz Achalandabaso ◽  
María J. García-Barcina
Keyword(s):  
Dna Sequences ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Restriction Enzymes ◽  
Circulating Free Dna ◽  
Free Dna ◽  
Chip Technology ◽  
Long Duration ◽  
Important Diagnostic Tool ◽  
Rate Of Success

AbstractBackground:Circulating free DNA (cfDNA) digestion with methylation sensitive restriction enzymes constitutes an important diagnostic tool for differentiating methylated from non-methylated DNA sequences. In the context of pregnancy, this is used to differentiate fetal from maternal DNA. Current protocols are of long duration and use multiple enzymes with different incubation and inactivating temperatures. We describe a short protocol for the digestion of circulating free DNA focused on its future adaptation to miniaturized microfluidic devices based on lab-on-a-chip technology.Methods:cfDNA was extracted from plasma samples of pregnant and non-pregnant women with chemagic Viral NA/gDNA and QIAamp circulating nucleic acids kits. For digestion protocol optimization, different methylation sensitive and insensitive restriction enzymes were used. Detection ofResults:The digestion protocol is optimized to a 3.5 h one-step protocol using the enzymes BstUI, BstY1 and HhaI resulting in a complete digestion of the hypomethylated maternalConclusions:This work provides a digestion protocol for cfDNA samples with a combination of temperatures (37 °C and 60 °C) and a protocol length (<4 h) which facilitates its adaptation to miniaturized microfluidic devices based on lab-on-a-chip technology. In this technology, the shorter the duration of the protocol, the greater the rate of success and the less sample evaporation.

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