scholarly journals Near-infrared and metal-free tetra(butylamino)phthalocyanine nanoparticles for dual modal cancer phototherapy

RSC Advances ◽  
2020 ◽  
Vol 10 (43) ◽  
pp. 25958-25965
Author(s):  
Ying-Jie Wu ◽  
Fan-Hong Lv ◽  
Jing-Lan Kan ◽  
Qun Guan ◽  
Anqi Xue ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Near Infrared ◽  
Composite Nanoparticles ◽  
Metal Free ◽  
Highly Efficient ◽  
Nir Laser

Two new HSA-involved tetra(butylamino)phthalocyanine composite nanoparticles, as highly efficient dual-phototherapy agents upon a single NIR laser irradiation, were reported.

scholarly journals Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia

2020 ◽  
Vol 8 (25) ◽  
pp. 5425-5433 ◽  
Author(s):  
Álvaro Cárcamo-Martínez ◽  
Brónach Mallon ◽  
Juan Domínguez-Robles ◽  
A. Sara Cordeiro ◽  
Maurizio Celentano ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Laser Irradiation ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Skin Model ◽  
Thickness Skin ◽  
Microneedle Arrays ◽  
First Time ◽  
Nir Laser ◽  
Deep Hyperthermia

We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

2019 ◽  
Vol 4 (37) ◽  
pp. eaau6584 ◽  
Author(s):  
Dangge Wang ◽  
Tingting Wang ◽  
Haijun Yu ◽  
Bing Feng ◽  
Lei Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Laser Irradiation ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Near Infrared ◽  
Checkpoint Inhibitors ◽  
Immunological Tolerance ◽  
Immune Checkpoint Blockade ◽  
Tumor Resistance ◽  
Nir Laser

Immunological tolerance of tumors is characterized by insufficient infiltration of cytotoxic T lymphocytes (CTLs) and immunosuppressive microenvironment of tumor. Tumor resistance to immune checkpoint inhibitors due to immunological tolerance is an ongoing challenge for current immune checkpoint blockade (ICB) therapy. Here, we report the development of tumor microenvironment–activatable anti-PDL1 antibody (αPDL1) nanoparticles for combination immunotherapy designed to overcome immunological tolerance of tumors. Combination of αPDL1 nanoparticle treatment with near-infrared (NIR) laser irradiation–triggered activation of photosensitizer indocyanine green induces the generation of reactive oxygen species, which promotes the intratumoral infiltration of CTLs and sensitizes the tumors to PDL1 blockade therapy. We showed that the combination of antibody nanoparticles and NIR laser irradiation effectively suppressed tumor growth and metastasis to the lung and lymph nodes in mouse models. The nanoplatform that uses the antibody nanoparticle alone both for immune stimulation and PDL1 inhibition could be readily adapted to other immune checkpoint inhibitors for improved ICB therapy.

Photo-Thermal Conversion and Stability of Gold and Silver Nanostructures

2014 ◽  
Vol 906 ◽  
pp. 204-213 ◽  
Author(s):  
Yuan Ni ◽  
Cai Xia Kan ◽  
Bo Cong ◽  
Jin Sheng Liu ◽  
Hai Ying Xu
Keyword(s):  
Surface Plasmon Resonance ◽  
Laser Irradiation ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Near Infrared ◽  
Shape Change ◽  
Thermal Conversion ◽  
Silver Nanostructures ◽  
Au Nanorods ◽  
Nir Laser

Gold and silver nanostructures (such as Au nanorods and Ag nanoplates) exhibit strong and tunable surface plasmon resonance in the near-infrared region (NIR). Under a certain NIR laser irradiation, noble metal nanostructrues achieve a high photo-thermal effect, which would be useful in the therapy. In this work, Au nanorods with longitude surface plasmon resonance (SPRL) shifting in the region of 650 ~1100 nm were synthesized by a seed method. Ag nanoplates and nanocubes with SPR located in the region of 650~850 nm were produced by a hydrothermal method. Through adjusting laser power and irradiating time, the photo-thermal conversions of these nanostructures were studied under NIR laser irradiation. Under low power laser (808 nm, <1W) irradiation, the shape of the Au nanorods are stable and the temperature of colloid increase from room temperature to ~57°C. However, Au nanorods undergo deformation from rod to spherical particle under irradiation of high power (808 nm laser; 6W; 1064nm laser, 7W), resulting in the disappearance of SPRL. Morphology evolutions and photo-thermal conversion of Ag nanostructures were also studied. Ag nanostructures have a lower photo-thermal conversion compared with that of Au nanorods colloid. Snipping and dendrite can be observed for Ag nanoplates after irradiating, while Ag nanocubes have no obvious shape change.

Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

2018 ◽  
Vol 6 (3) ◽  
pp. 473-477 ◽  
Author(s):  
F. Q. Cao ◽  
M. M. Yan ◽  
Y. J. Liu ◽  
L. X. Liu ◽  
L. Lu ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Laser Irradiation ◽  
T Lymphocyte ◽  
Self Assembly ◽  
Near Infrared ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Cross Presentation ◽  
Cytotoxic T Lymphocyte Response ◽  
Nir Laser

Under near-infrared (NIR) laser irradiation, ICG–antigen conjugate-based nanovaccines enhanced the cross-presentation of antigens and induced cytotoxic T lymphocyte response.

scholarly journals Indocyanine Green and Methyl-β-Cyclodextrin Complex for Enhanced Photothermal Cancer Therapy

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 476 ◽  
Author(s):  
Gayoung Jo ◽  
Bo Young Lee ◽  
Eun Jeong Kim ◽  
Min Ho Park ◽  
Hoon Hyun
Keyword(s):  
Cancer Therapy ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Body Weight Loss ◽  
Photothermal Effect ◽  
Cyclodextrin Complex ◽  
Photothermal Treatment ◽  
Potential Strategy ◽  
Nir Laser

A feasible and biocompatible supramolecular complex self-assembled from indocyanine green (ICG) and methyl-β-cyclodextrin (Mβ-CD) was developed for targeted cancer imaging, which enhanced fluorescence-guided photothermal cancer therapy. This study confirmed that the formation of an inclusion complex of the heterocyclic ICG moiety and Mβ-CD inner cavity could result in improved tumor targetability compared with free ICG. The ICG-CD complex could be used as a bifunctional phototherapeutic agent for targeted cancer phototherapy due to the high tumor targetability of the Mβ-CD moiety and effective photothermal performance of the near-infrared (NIR) ICG moiety. Upon NIR laser irradiation, the photothermal effect exerted by the ICG-CD complex significantly enhanced the temperature at the tumor site by 56.2 °C within 5 min. Targeting HT-29 tumors using the ICG-CD complex resulted in an apparent reduction in tumor volumes over the 9 days after photothermal treatment. Moreover, no tumor recurrence or body weight loss were observed after administering a single dose of ICG-CD complex with NIR laser irradiation. Therefore, the administration of the biocompatible ICG-CD complex in combination with NIR laser treatment can be safely explored as a potential strategy for future clinical applications.

Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61141-61149 ◽  
Author(s):  
Farhad Bani ◽  
Mohsen Adeli ◽  
Soodabeh Movahedi ◽  
Majid Sadeghizadeh
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Chemotherapeutic Drug ◽  
Stimuli Responsive ◽  
Nano Graphene ◽  
Nir Laser

The aim of this study is to develop a nano graphene–polyglycerol–curcumin hybrid capable of simultaneous co-delivery of chemotherapeutic drug and cytotoxic heat to cancer cells by near infrared (NIR) laser irradiation.

Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatially/temporally controlled drug release triggered by NIR laser irradiation

2020 ◽  
Vol 44 (21) ◽  
pp. 8705-8709
Author(s):  
Lu Li ◽  
Wancheng Zhao ◽  
Zheng Qu ◽  
Lei Shi ◽  
Shengnan Tan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Laser Irradiation ◽  
Anticancer Drugs ◽  
Near Infrared ◽  
Biomedical Application ◽  
Controlled Drug Release ◽  
Nir Light ◽  
Responsive Hydrogels ◽  
Nir Laser

Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in the remote-controlled release of anticancer drugs.

scholarly journals Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bing Liu ◽  
Jian Zhou ◽  
Bin Zhang ◽  
Jing Qu
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Cell Counting ◽  
Photothermal Effect ◽  
Ovarian Cancer Cells ◽  
Photothermal Treatment ◽  
Skov3 Cells ◽  
Nir Laser

Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.

Near-infrared light-induced imaging and targeted anti-cancer therapy based on a yolk/shell structure

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21590-21599 ◽  
Author(s):  
Ruichan Lv ◽  
Chongna Zhong ◽  
Arif Kuhan Gulzar ◽  
Fei He ◽  
Rui Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Laser Irradiation ◽  
Shell Structure ◽  
Near Infrared ◽  
Antitumor Efficacy ◽  
Infrared Light ◽  
Anti Cancer ◽  
Bio Imaging ◽  
Nir Laser

Yolk/shell mesoporous NaYF4:Yb,Er@MgSiO3–ZnPc–RGD spheres have been fabricated to combine photodynamic therapy (PDT) and bio-imaging for improved antitumor efficacy under NIR laser irradiation.

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