Near-infrared light-induced imaging and targeted anti-cancer therapy based on a yolk/shell structure

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21590-21599 ◽  
Author(s):  
Ruichan Lv ◽  
Chongna Zhong ◽  
Arif Kuhan Gulzar ◽  
Fei He ◽  
Rui Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Laser Irradiation ◽  
Shell Structure ◽  
Near Infrared ◽  
Antitumor Efficacy ◽  
Infrared Light ◽  
Anti Cancer ◽  
Bio Imaging ◽  
Nir Laser

Yolk/shell mesoporous NaYF4:Yb,Er@MgSiO3–ZnPc–RGD spheres have been fabricated to combine photodynamic therapy (PDT) and bio-imaging for improved antitumor efficacy under NIR laser irradiation.

scholarly journals A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

2016 ◽  
Vol 7 (7) ◽  
pp. 4237-4244 ◽  
Author(s):  
Zhengze Yu ◽  
Wei Pan ◽  
Na Li ◽  
Bo Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Resistance ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Laser Irradiation ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Cancer Multiple ◽  
Nir Laser

A nuclear targeted dual-photosensitizer was developed for photodynamic therapy against multidrug resistant cancer. Multiple reactive oxygen species (ROS) could be generated in the nucleus to directly break DNA double strands with a single 980 nm NIR laser irradiation, regardless of drug resistance.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

scholarly journals Indocyanine Green and Methyl-β-Cyclodextrin Complex for Enhanced Photothermal Cancer Therapy

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 476 ◽  
Author(s):  
Gayoung Jo ◽  
Bo Young Lee ◽  
Eun Jeong Kim ◽  
Min Ho Park ◽  
Hoon Hyun
Keyword(s):  
Cancer Therapy ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Body Weight Loss ◽  
Photothermal Effect ◽  
Cyclodextrin Complex ◽  
Photothermal Treatment ◽  
Potential Strategy ◽  
Nir Laser

A feasible and biocompatible supramolecular complex self-assembled from indocyanine green (ICG) and methyl-β-cyclodextrin (Mβ-CD) was developed for targeted cancer imaging, which enhanced fluorescence-guided photothermal cancer therapy. This study confirmed that the formation of an inclusion complex of the heterocyclic ICG moiety and Mβ-CD inner cavity could result in improved tumor targetability compared with free ICG. The ICG-CD complex could be used as a bifunctional phototherapeutic agent for targeted cancer phototherapy due to the high tumor targetability of the Mβ-CD moiety and effective photothermal performance of the near-infrared (NIR) ICG moiety. Upon NIR laser irradiation, the photothermal effect exerted by the ICG-CD complex significantly enhanced the temperature at the tumor site by 56.2 °C within 5 min. Targeting HT-29 tumors using the ICG-CD complex resulted in an apparent reduction in tumor volumes over the 9 days after photothermal treatment. Moreover, no tumor recurrence or body weight loss were observed after administering a single dose of ICG-CD complex with NIR laser irradiation. Therefore, the administration of the biocompatible ICG-CD complex in combination with NIR laser treatment can be safely explored as a potential strategy for future clinical applications.

Graphene–polyglycerol–curcumin hybrid as a near-infrared (NIR) laser stimuli-responsive system for chemo-photothermal cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61141-61149 ◽  
Author(s):  
Farhad Bani ◽  
Mohsen Adeli ◽  
Soodabeh Movahedi ◽  
Majid Sadeghizadeh
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Chemotherapeutic Drug ◽  
Stimuli Responsive ◽  
Nano Graphene ◽  
Nir Laser

The aim of this study is to develop a nano graphene–polyglycerol–curcumin hybrid capable of simultaneous co-delivery of chemotherapeutic drug and cytotoxic heat to cancer cells by near infrared (NIR) laser irradiation.

AgBiS2-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

2019 ◽  
Vol 7 (11) ◽  
pp. 4769-4781 ◽  
Author(s):  
Mingdi Sun ◽  
Dan Yang ◽  
Chen Wang ◽  
Huiting Bi ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Mitochondrial Targeting ◽  
Nir Light ◽  
Bio Imaging ◽  
First Time ◽  
Nir Laser

AgBiS2 nanodots as an NIR light-excited photosensitizer produce a PDT effect, which is reported for the first time.

Near-infrared light-induced dissociation of zeolitic imidazole framework-8 (ZIF-8) with encapsulated CuS nanoparticles and their application as a therapeutic nanoplatform

2016 ◽  
Vol 52 (82) ◽  
pp. 12210-12213 ◽  
Author(s):  
Zhifei Wang ◽  
Xuejiao Tang ◽  
Xiaoxiao Wang ◽  
Dandan Yang ◽  
Chao Yang ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Laser

A new therapeutic nanoplatform based on CuS@ZIF-8NPs was developed, which could be disintegrated under NIR laser irradiation at pH 7.4.

Doxorubicin-conjugated CuS nanoparticles for efficient synergistic therapy triggered by near-infrared light

2016 ◽  
Vol 45 (12) ◽  
pp. 5101-5110 ◽  
Author(s):  
Huiting Bi ◽  
Yunlu Dai ◽  
Ruichan Lv ◽  
Chongna Zhong ◽  
Fei He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Irradiation ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Copper Sulfide ◽  
Near Infrared ◽  
Infrared Light ◽  
Anti Cancer

A CuS–DOX NP drug delivery system was synthesized by conjugating carboxyl-functionalized copper sulfide nanoparticles (CuS NPs) and DOX through hydrazone bonds. The platform exhibits high in vitro and in vivo anti-cancer efficacy due to the combined chemo- and photothermal therapeutic effect upon 808 nm laser irradiation.

scholarly journals Ruthenium(ii) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

2016 ◽  
Vol 4 (7) ◽  
pp. 1337-1342 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Vanja Stojanovic ◽  
Arnaud Chaix ◽  
Elise Bouffard ◽  
Khaled El Cheikh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Porous Silicon ◽  
Cancer Therapy ◽  
Silicon Nanoparticles ◽  
Near Infrared ◽  
Infrared Light ◽  
Porous Si ◽  
Near Infrared Light ◽  
Two Photon ◽  
Photodynamic Cancer Therapy

Multifunctionalized porous Si NPs and their application in NIR photodynamic therapy and imaging of cancer are reported.

A near-infrared light-controlled, oxygen-independent radical generating nano-system toward cancer therapy

2021 ◽  
Author(s):  
Desheng Cao ◽  
Hua He ◽  
Wei Li ◽  
Jin Yan ◽  
Jianhua Wu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Prussian Blue ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Alkyl Radicals ◽  
Prussian Blue Nanoparticles ◽  
Anti Cancer

AIBI-loaded mesoporous Prussian blue nanoparticles (AP@HPB NPs) were developed to achieve near-infrared light-controlled, oxygen-independent generation of alkyl radicals toward anti-cancer treatment.

scholarly journals Recent Near-Infrared Light-Activated Nanomedicine toward Precision Cancer Therapy

2021 ◽  
Author(s):  
Xiaowei Luan ◽  
Yongchun Pan ◽  
Yanfeng Gao ◽  
Yujun Song
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Human Society ◽  
Near Infrared Light ◽  
History Of ◽  
The Universe

Light has witnessed the history of mankind and even the universe. It is of great significances to the life of human society, contributing to energy, agriculture, communication, and much more....

Sign in / Sign up

Export Citation Format

Share Document