scholarly journals Fe3O4@SiO2@Au nanoparticles for MRI-guided chemo/NIR photothermal therapy of cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (44) ◽  
pp. 26508-26520
Author(s):  
Alexey Maximenko ◽  
Joanna Depciuch ◽  
Natalia Łopuszyńska ◽  
Malgorzata Stec ◽  
Żaneta Światkowska-Warkocka ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Au Nanoparticles ◽  
Functionalized Nanoparticles ◽  
Photothermal Treatment ◽  
Mri Guided

Novel functionalized nanoparticles, with toxicity controlled by laser irradiation, are perspective agents for potential (MRI)-guided stimulated chemo-photothermal treatment of cancer.

scholarly journals Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bing Liu ◽  
Jian Zhou ◽  
Bin Zhang ◽  
Jing Qu
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Cell Counting ◽  
Photothermal Effect ◽  
Ovarian Cancer Cells ◽  
Photothermal Treatment ◽  
Skov3 Cells ◽  
Nir Laser

Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe3O4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe3O4 nanoparticles have promising applications in photothermal treatment of cancer cells.

scholarly journals Platinum–gold nanoraspberries as effective photosensitizer in anticancer photothermal therapy

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
J. Depciuch ◽  
M. Stec ◽  
B. Klebowski ◽  
J. Baran ◽  
M. Parlinska-Wojtan
Keyword(s):  
Cancer Cells ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Protein Structures ◽  
Anticancer Therapy ◽  
Colon Cancer Cell ◽  
Colon Cancer Cell Lines ◽  
Light Absorbers ◽  
Microscopy Images ◽  
Mts Assay

Abstract Background New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT. Results Light microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation combined with PtAu NRs caused visible changes in the cell morphology. Fourier Transform InfraRed (FTIR) and Raman spectroscopies showed chemical changes in the DNA, phospholipids, lipids and protein structures caused by laser irradiation in the presence of PtAu NRs. The MTS assay showed ~ 25% mortality of cancer cells due to the addition of PtAu NRs to the cell culture, while for laser irradiation combined with nanoparticles, the mortality of cancer cells increased to 65% for the 650 nm laser and to 60% for the 808 nm laser. The calculated photothermal conversion efficiency reached 62% and 51% for the 650 nm and 808 nm lasers, respectively. Conclusions PtAu NRs could be applied as effective light-absorbers in the PTT anticancer therapy.

Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

2015 ◽  
Vol 44 (6) ◽  
pp. 2771-2779 ◽  
Author(s):  
Yuxin Zhang ◽  
Bo Li ◽  
Yunjiu Cao ◽  
Jinbao Qin ◽  
Zhiyou Peng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Ct Imaging ◽  
Dual Model ◽  
Photothermal Treatment ◽  
Nir Absorption

The hydrophilic Na0.3WO3 nanorods showed intense NIR absorption and large HU value, and thus can be used as a promising multifunctional agent for CT imaging and photothermal treatment of cancer.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

In vitro and in vivo synergistic effect of radiotherapy and plasmonic photothermal therapy on the viability of cancer cells using 177Lu–Au-NLS-RGD-Aptamer nanoparticles under laser irradiation

2018 ◽  
Vol 318 (3) ◽  
pp. 1913-1921 ◽  
Author(s):  
Abraham González-Ruíz ◽  
Guillermina Ferro-Flores ◽  
Nallely Jiménez-Mancilla ◽  
Alondra Escudero-Castellanos ◽  
Blanca Ocampo-García ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Plasmonic Photothermal Therapy

Metallic oxide nanocrystals with near-infrared plasmon resonance for efficient, stable and biocompatible photothermal cancer therapy

2017 ◽  
Vol 5 (35) ◽  
pp. 7393-7402 ◽  
Author(s):  
Kang Dou ◽  
Wenwen Zhu ◽  
Yousheng Zou ◽  
Yu Gu ◽  
Jubin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Temperature Elevation ◽  
Inhibition Rate ◽  
Metallic Oxide ◽  
Tumor Inhibition

The synthesized MoO2 nanocrystals exhibit excellent photothermal temperature elevation of about 37.5 °C under 808 nm laser irradiation, and tumor inhibition effects with an inhibition rate of up to 80.45% as a photothermal therapy agent against 4T1 cancer cells.

A metal–organic framework based nanocomposite with co-encapsulation of Pd@Au nanoparticles and doxorubicin for pH- and NIR-triggered synergistic chemo-photothermal treatment of cancer cells

2017 ◽  
Vol 5 (24) ◽  
pp. 4648-4659 ◽  
Author(s):  
Xue Yang ◽  
Liling Li ◽  
Dinggeng He ◽  
Luo Hai ◽  
Jinlu Tang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Au Nanoparticles ◽  
Metal Organic Framework ◽  
Photothermal Treatment ◽  
Metal Organic ◽  
Organic Framework

A novel metal–organic framework nanocomposite with co-encapsulating of Pd@Au nanoparticles and doxorubicin for chemo-photothermal treatment of cancer cells.

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

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