scholarly journals Synthesis of polyacrylonitrile nanoflowers and their controlled pH-sensitive drug release behavior

RSC Advances ◽  
2020 ◽  
Vol 10 (27) ◽  
pp. 15715-15725 ◽  
Author(s):  
Qi Lian ◽  
Han Liu ◽  
Xuefang Zheng ◽  
Dandan Jia ◽  
Chun Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Potential Application ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Drug Release Behavior

The schematic preparation of a new kind of pH-sensitive PAN nanoflower and its potential application for UC therapy. PAN (TBP) nanoflowers at pH 7.4 showed good sustained-release (t83% = 260 h), which best fitted the Riger–Peppas model.

pH-Sensitive graphene oxide conjugate purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy

2018 ◽  
Vol 42 (16) ◽  
pp. 13272-13284 ◽  
Author(s):  
Ying Zhang ◽  
Hongyue Zhang ◽  
Zhiqiang Wang ◽  
Yingxue Jin
Keyword(s):  
Graphene Oxide ◽  
Photodynamic Therapy ◽  
Methyl Ester ◽  
Drug Release ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Drug Release Behavior

A GO–Pu18 composite showed excellent photodynamic bioactivity and pH-sensitive drug release behavior.

scholarly journals pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1974
Author(s):  
Juan Carlos Quintanilla de Stéfano ◽  
Vanessa Abundis-Correa ◽  
Sergio Daniel Herrera-Flores ◽  
Alejandro J. Alvarez
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Crosslinking Agent ◽  
Ph Sensitive ◽  
Fickian Diffusion ◽  
Butyl Methacrylate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Swelling Capacity

The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.

scholarly journals Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine

RSC Advances ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 6287-6298 ◽  
Author(s):  
Yuanfeng Wei ◽  
Jianjun Zhang ◽  
Yazhen Zheng ◽  
Yaxiang Gong ◽  
Meng Fu ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Oral Bioavailability ◽  
Release Behavior ◽  
Sustained Drug Release ◽  
Bioavailability Enhancement ◽  
Drug Release Behavior

Cubosomes with surface cross-linked chitosan exhibit anti-digestion effect, sustained drug release behavior, and significantly enhanced oral bioavailability of vinpocetine.

pH-sensitive keratin-based polymer hydrogel and its controllable drug-release behavior

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Juhua Guo ◽  
Sujuan Pan ◽  
Xiaochun Yin ◽  
Yu-Feng He ◽  
Tao Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Polymer Hydrogel ◽  
Drug Release Behavior
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