Thermo- and pH-sensitive dendrimer derivatives with a shell of poly(N,N-dimethylaminoethyl methacrylate) and study of their controlled drug release behavior

Polymer ◽  
2005 ◽  
Vol 46 (22) ◽  
pp. 9514-9522 ◽  
Author(s):  
Hu Hui ◽  
Fan Xiao-dong ◽  
Cao Zhong-lin
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Dimethylaminoethyl Methacrylate

scholarly journals Heat Treatment Induced Specified Aggregation Morphology of Metoprolol Tartrate in Poly(ε-caprolactone) Matrix and the Drug Release Variation

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3076
Author(s):  
Zhiyu Liu ◽  
Hangling Song ◽  
Xia Chen ◽  
Aichun Han ◽  
Guiting Liu ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Treatment Method ◽  
Melt Processing ◽  
Metoprolol Tartrate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Phosphate Buffered Saline ◽  
Hot Melt

Hot-melt blending has been widely used in the pharmaceutical industry to produce drug delivery systems, however, realizing the controlled drug release behavior of a hot-melt blended medicament it is still a tough challenge. In this study, we developed a simple and effective heat treatment method to adjust the drug release behavior, without the addition of any release modifiers. Thin metoprolol tartrate (MPT)/poly(ε-caprolactone) (PCL) tablets were prepared through hot-melt processing, and different morphologies of MPT were obtained by altering processing temperatures and the following heat treatment. MPT particles with different particle sizes were obtained under different processing temperatures, and fibrous crystals of MPT were fabricated during the following heat treatment. Different morphological structures of MPT adjusted the drug diffusion channel when immersed in phosphate-buffered saline (PBS), and various drug release behaviors were approached. After being immersed for 24 h, 7% of the MPT was released from the blend processed at 130 °C, while more than 95% of the MPT were released after the following heat treatment of the same sample. Thus, flexible drug release behaviors were achieved using this simple and effective processing manufacture, which is demonstrated to be of profound importance for biomedical applications.

pH-Sensitive graphene oxide conjugate purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy

2018 ◽  
Vol 42 (16) ◽  
pp. 13272-13284 ◽  
Author(s):  
Ying Zhang ◽  
Hongyue Zhang ◽  
Zhiqiang Wang ◽  
Yingxue Jin
Keyword(s):  
Graphene Oxide ◽  
Photodynamic Therapy ◽  
Methyl Ester ◽  
Drug Release ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Drug Release Behavior

A GO–Pu18 composite showed excellent photodynamic bioactivity and pH-sensitive drug release behavior.

scholarly journals pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1974
Author(s):  
Juan Carlos Quintanilla de Stéfano ◽  
Vanessa Abundis-Correa ◽  
Sergio Daniel Herrera-Flores ◽  
Alejandro J. Alvarez
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Crosslinking Agent ◽  
Ph Sensitive ◽  
Fickian Diffusion ◽  
Butyl Methacrylate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Swelling Capacity

The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.

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