Reduction-responsive disulfide linkage core-cross-linked polymeric micelles for site-specific drug delivery

2020 ◽  
Vol 11 (44) ◽  
pp. 7078-7086
Author(s):  
Gaizhen Kuang ◽  
Qingfei Zhang ◽  
Shasha He ◽  
Yanjuan Wu ◽  
Yubin Huang
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Specific Drug ◽  
Disulfide Linkage ◽  
Site Specific ◽  
Doxorubicin Delivery ◽  
Effective Site

Reduction-responsive disulfide linkage core-cross-linked polymeric micelles (CLM@DOX) were developed for effective site-specific doxorubicin delivery.

Deep Eutectic Solvent-Mediated FA-g-β-Alanine-co-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

2018 ◽  
Vol 1 (6) ◽  
pp. 2094-2109 ◽  
Author(s):  
Periyakaruppan Pradeepkumar ◽  
Naresh Kumar Rajendran ◽  
Abdullah A. Alarfaj ◽  
Murugan A. Munusamy ◽  
Mariappan Rajan
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Deep Eutectic Solvent ◽  
Specific Drug ◽  
Site Specific

In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

2001 ◽  
Vol 73 (1) ◽  
pp. 103-110 ◽  
Author(s):  
M.E Sangalli ◽  
A Maroni ◽  
L Zema ◽  
C Busetti ◽  
F Giordano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
In Vivo Evaluation ◽  
Site Specific

Peas starch-based film coatings for site-specific drug delivery to the colon

2010 ◽  
Vol 119 (2) ◽  
pp. 1176-1184 ◽  
Author(s):  
Y. Karrout ◽  
C. Neut ◽  
D. Wils ◽  
F. Siepmann ◽  
L. Deremaux ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
Site Specific ◽  
Film Coatings

Development of cholate conjugated hybrid polymeric micelles for FXR receptor mediated effective site-specific delivery of paclitaxel

2018 ◽  
Vol 42 (20) ◽  
pp. 17021-17032 ◽  
Author(s):  
Sivaraj Mehnath ◽  
Mukherjee Arjama ◽  
Mariappan Rajan ◽  
Murugaraj Jeyaraj
Keyword(s):  
Cholic Acid ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Site Specific ◽  
Effective Delivery ◽  
Effective Site ◽  
Micelle System

The aim of the present study was to explore the tumor targeting potential of a cholic acid (CA) conjugated polymeric micelle system for the effective delivery of paclitaxel (PTX).

scholarly journals Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

2019 ◽  
Vol 13 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Surya Goel ◽  
Monika Sachdeva ◽  
Vijay Agarwal
Keyword(s):  
Drug Delivery ◽  
Crucial Role ◽  
Specific Drug ◽  
Poorly Soluble Drugs ◽  
Site Specific ◽  
The Past ◽  
Dosing Frequency ◽  
The Future ◽  
Poorly Soluble

Background: Nanosuspension has arisen as a remunerative, lucrative as well as a potent approach to improve the solubility and bioavailability of poorly aqueous soluble drug entities. Several challenges are still present in this approach which need more research. The prime aim of this review is to identify such challenges that can be rectified in the future. Methods: Through this review, we enlighten the recent patents and advancement in nanosuspension technology that utilize the different drug moieties, instruments and characterization parameters. Results: Nanosuspension has been found to possess great potential to rectify the several issues related to poor bioavailability, site-specific drug delivery, dosing frequency, etc. In the past decade, nanosuspension approach has been complementarily utilized to solve the developed grievances, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries. Conclusion: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involving oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare.

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