Deep Eutectic Solvent-Mediated FA-g-β-Alanine-co-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

2018 ◽  
Vol 1 (6) ◽  
pp. 2094-2109 ◽  
Author(s):  
Periyakaruppan Pradeepkumar ◽  
Naresh Kumar Rajendran ◽  
Abdullah A. Alarfaj ◽  
Murugan A. Munusamy ◽  
Mariappan Rajan
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Deep Eutectic Solvent ◽  
Specific Drug ◽  
Site Specific

scholarly journals Surface modified receptor mediated delivery systems for site specific treatment of cancer

2021 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
Fenil Vanapariya ◽  
Miteshkumar Malviya ◽  
Shiroya Milankumar Nathabhai
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Carrier ◽  
Specific Treatment ◽  
The Body ◽  
Cancer Drug ◽  
Specific Drug ◽  
Formulation Development ◽  
Site Specific ◽  
Surface Modified

The treatment of the cancer has many challenges now a days due to side effects of the treatment. However, in the modern formulation development the concept of the site specific drug delivery for disease treatment in the body is considering as continuous challenges. Observing the challenges in convectional technique site specific drug delivery system has good potential to reduce adverse side effects, efficiently improve the human body health with very low toxicity. This review article elaborates the current challenges and prospective of surface modified drug carrier systems for delivery of protein for site-specific treatment of cancer and anti-cancer drug.

In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

2001 ◽  
Vol 73 (1) ◽  
pp. 103-110 ◽  
Author(s):  
M.E Sangalli ◽  
A Maroni ◽  
L Zema ◽  
C Busetti ◽  
F Giordano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
In Vivo Evaluation ◽  
Site Specific

Peas starch-based film coatings for site-specific drug delivery to the colon

2010 ◽  
Vol 119 (2) ◽  
pp. 1176-1184 ◽  
Author(s):  
Y. Karrout ◽  
C. Neut ◽  
D. Wils ◽  
F. Siepmann ◽  
L. Deremaux ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
Site Specific ◽  
Film Coatings

scholarly journals Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations

2019 ◽  
Vol 13 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Surya Goel ◽  
Monika Sachdeva ◽  
Vijay Agarwal
Keyword(s):  
Drug Delivery ◽  
Crucial Role ◽  
Specific Drug ◽  
Poorly Soluble Drugs ◽  
Site Specific ◽  
The Past ◽  
Dosing Frequency ◽  
The Future ◽  
Poorly Soluble

Background: Nanosuspension has arisen as a remunerative, lucrative as well as a potent approach to improve the solubility and bioavailability of poorly aqueous soluble drug entities. Several challenges are still present in this approach which need more research. The prime aim of this review is to identify such challenges that can be rectified in the future. Methods: Through this review, we enlighten the recent patents and advancement in nanosuspension technology that utilize the different drug moieties, instruments and characterization parameters. Results: Nanosuspension has been found to possess great potential to rectify the several issues related to poor bioavailability, site-specific drug delivery, dosing frequency, etc. In the past decade, nanosuspension approach has been complementarily utilized to solve the developed grievances, arisen from poorly soluble drugs. But this field still needs more attention to new discoveries. Conclusion: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involving oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare.

scholarly journals Albumin coated liposomes: a novel platform for macrophage specific drug delivery

2011 ◽  
Vol 1 (1) ◽  
pp. 2 ◽  
Author(s):  
Clément Vuarchey ◽  
Sushil Kumar ◽  
Reto Schwendener
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Cell Types ◽  
Specific Drug ◽  
Splenic Macrophages ◽  
Peg Liposomes ◽  
Short Time ◽  
Liposome Surface

Here we report a new and efficient approach of macrophage specific drug delivery by coating liposomes with albumin. Activated albumin was reacted with liposomes containing polyethylene glycol (PEG) as hydrophilic spacers to create a flexible layer of covalently bound albumin molecules on the liposome surface. Albumin coated liposomes were taken up faster and more efficiently than uncoated liposomes by murine macrophages. Liposome uptake was significantly higher in macropha - ges as compared to other cell types tested (endothelial cells, fibroblasts, tumor cells), suggesting specificity for macrophages. In vivo, splenic macrophages phagocytosed BSA coated liposomes (BSA-L) at faster rates compared to conventional liposomes (L) and PEG liposomes (PEG-L). To prove the effectiveness of this new macrophage specific drug carrier, the bisphosphonates clodronate and zoledronate were encapsulated in BSA-L and compared with conventional liposomes. <em>In vitro</em>, treatment of macrophages with clodronate or zoledronate in BSA-L led to cytotoxic activity within a very short time and to up to 50-fold reduced IC50 concentrations. <em>In vivo</em>, clodronate encapsulated in BSA-L depleted splenic macrophages at a 5-fold lower concentration as conventional clodronate-liposomes. Our results highlight the pharmaceutical benefits of albumin-coated liposomes for macrophage specific drug delivery.

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