Calcium-catalyzed formal [3 + 2] annulation of C,N-diacyliminium ions with nucleophilic phenols: a diversity oriented synthesis of 3-aminofurans

2021 ◽  
Author(s):  
Rajesh P. ◽  
Abdulrahman I. Almansour ◽  
Natarajan Arumugam ◽  
Srinivasarao Yaragorla
Keyword(s):  
Cascade Reaction ◽  
Solvent Free ◽  
One Pot ◽  
Diversity Oriented Synthesis

We report a one-pot, three-component, solvent-free, cascade reaction for the synthesis of 3-aminofurans using a calcium catalyst, in which, the in situ formed C,N-diacyliminium ion, is the key intermediate.

Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction

2018 ◽  
Vol 360 (19) ◽  
pp. 3655-3661 ◽  
Author(s):  
Gui-Ting Song ◽  
Nicholas McConnell ◽  
Zhong-Zhu Chen ◽  
Xiao-Fang Yao ◽  
Jiu-Hong Huang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Cascade Reaction ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Metal Free ◽  
Anti Cancer ◽  
Cancer Activity

Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via the Groebke–Blackburn–Bienaymé and TBAB-Mediated Cascade Reaction in One Pot

2019 ◽  
Vol 84 (19) ◽  
pp. 12632-12638 ◽  
Author(s):  
Yong Li ◽  
Jiu-Hong Huang ◽  
Juan-Li Wang ◽  
Gui-Ting Song ◽  
Dian-Yong Tang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cascade Reaction ◽  
One Pot ◽  
Diversity Oriented Synthesis

Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)–H functionalization of 2-alkylazaarenes

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103091-103094 ◽  
Author(s):  
Santosh S. Chavan ◽  
Mohsinkhan Y. Pathan ◽  
Shafeek A. R. Mulla
Keyword(s):  
Michael Addition ◽  
Cascade Reaction ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
One Pot

A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the efficient synthesis of β-azaarene substituted ketones via an aldol–Michael addition/C(sp3)–H functionalization of 2-alkylazaarenes has been developed.

scholarly journals Solvent-free preparation of amidoalkyl phenols catalyzed by trityl chloride under neutral media

2015 ◽  
Vol 93 (11) ◽  
pp. 1245-1248 ◽  
Author(s):  
Ahmad Reza Moosavi-Zare ◽  
Mohammad Ali Zolfigol ◽  
Fateme Derakhshan-Panah ◽  
Masoume Daraei
Keyword(s):  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Solvent Free ◽  
One Pot ◽  
Multicomponent Condensation ◽  
Solvent Free Condition ◽  
Neutral Media ◽  
In Situ Generation

A one-pot, multicomponent condensation reaction of phenols, aromatic aldehydes, and amides in the presence of catalytic amount of trityl chloride as a homogeneous organocatalyst under solvent-free condition to prepare amidoalkyl phenols has been reported. It is interesting that trityl chloride by in situ generation of trityl carbocation with inherent instability catalyzes the reaction.

One-pot cascade synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans via ortho-quinone methide intermediates generated in situ

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14892-14896 ◽  
Author(s):  
Abdul kadar Shaikh ◽  
George Varvounis
Keyword(s):  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Quinone Methide ◽  
One Pot

A simple and efficient one-pot cascade reaction for the regioselective synthesis of trans or cis/trans-2,3-disubstituted 2,3-dihydrobenzofurans, is described.

Solvent-free accelerated organic syntheses using microwaves

2001 ◽  
Vol 73 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Rajender S. Varma
Keyword(s):  
Organic Synthesis ◽  
High Speed ◽  
Multicomponent Reactions ◽  
Solvent Free ◽  
Parallel Synthesis ◽  
One Pot ◽  
Reduction Reactions ◽  
Heterocyclic Molecules ◽  
Organic Syntheses

A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solvent-free MW approach to multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.

One-pot synthesis of β-lactams by the Ugi and Michael addition cascade reaction

2018 ◽  
Vol 16 (33) ◽  
pp. 6096-6105 ◽  
Author(s):  
Xing Gao ◽  
Chunhui Shan ◽  
Zhihao Chen ◽  
Yan Liu ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Michael Addition ◽  
Michael Reaction ◽  
Cascade Reaction ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Reaction Cascades

A diversity-oriented synthesis of β-lactams via Ugi/Michael reaction cascades under mild conditions was achieved.

scholarly journals In Situ Growth of ZIF-8 Nanocrystals on the Pore Walls of 3D Ordered Macroporous TiO2 for a One-Pot Cascade Reaction

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 533
Author(s):  
Jing Chen ◽  
Yingchun Guo ◽  
Tengteng Kang ◽  
Xingchi Liu ◽  
Xiaomei Wang ◽  
...  
Keyword(s):  
Crystallization Process ◽  
Knoevenagel Condensation ◽  
Cascade Reaction ◽  
Multifunctional Composites ◽  
One Pot ◽  
Visible Light Absorption ◽  
Multiple Components ◽  
Ordered Macroporous ◽  
The One

It is wise to mimic a bioinspired system to design a nanoreactor as a catalyst containing multiple components for a cascade reaction. Here, we report the uniform growth of well-dispersed nano-scale ZIF-8 crystals on the pore walls of 3DOM TiO2 via the TEA-assisted crystallization process. The UV-vis spectra indicate that the ZIF-8 photosensitizer can extend the visible-light absorption of 3DOM TiO2. The obtained nanoreactor can efficiently catalyze the one-pot aromatic alcohol oxidization and Knoevenagel condensation cascade reaction for larger molecules. This work offers an important strategy for preparing semiconductor–MOF multifunctional composites with a spatially separated compartmentation for the cascade reaction.

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