A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture

2020 ◽  
Vol 18 (22) ◽  
pp. 4164-4168
Author(s):  
Pramila Devi ◽  
Mallikharjuna Rao Lambu ◽  
Sundarababu Baskaran
Keyword(s):  
Stereoselective Synthesis ◽  
Reaction Medium ◽  
One Pot ◽  
Metal Free

A metal free method for the stereoselective synthesis of tetrahydropyrimidinone from a vinyl arene has been developed using a low melting mixture as a novel reaction medium.

scholarly journals One-Pot Metal-Free Synthesis of 3-CF3-1,3-Oxazinopyridines by Reaction of Pyridines with CF3CO-Acetylenes

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3594 ◽  
Author(s):  
Muzalevskiy ◽  
Sizova ◽  
Belyaeva ◽  
Trofimov ◽  
Nenajdenko
Keyword(s):  
Stereoselective Synthesis ◽  
One Pot ◽  
Metal Free

The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found that the reaction of various pyridines with two molecules of CF3CO-acetylenes proceeds under mild metal-free conditions. As a result, efficient stereoselective synthesis of 3-arylethynyl-3-trifluoromethyl-1,3-oxazinopyridines was elaborated. Target heterocycles can be prepared in up to quantitative yields.

scholarly journals One-Pot Synthesis of Star Copolymers by the Combination of Metal-Free ATRP and ROP Processes

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1577 ◽  
Author(s):  
Gorkem Yilmaz
Keyword(s):  
Visible Light Irradiation ◽  
Ring Opening ◽  
Reaction Medium ◽  
Ring Opening Polymerization ◽  
One Pot ◽  
Metal Free ◽  
Molecular Weights ◽  
Star Copolymers ◽  
Living Polymerizations ◽  
Chromatographic Evidence

A completely metal-free strategy is demonstrated for the preparation of star copolymers by combining atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP) for the syntheses of block copolymers. These two different metal-free controlled/living polymerizations are simultaneously realized in one reaction medium in an orthogonal manner. For this purpose, a specific core with functional groups capable of initiating both polymerization types is synthesized. Next, vinyl and lactone monomers are simultaneously polymerized under visible light irradiation using specific catalysts. Spectral and chromatographic evidence demonstrates the success of the strategy as star copolymers are synthesized with controlled molecular weights and narrow distributions.

Organobase catalysed one-pot exo-selective synthesis of meso-spiro[cyclohexanone-pyrandione] derivatives

2017 ◽  
Vol 41 (19) ◽  
pp. 10790-10798 ◽  
Author(s):  
Oualid Talhi ◽  
Hasnia Abdeldjebar ◽  
Yamina Belmiloud ◽  
Ridha Hassaine ◽  
Nadia Taibi ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Selective Synthesis ◽  
Conjugate Additions ◽  
One Pot ◽  
Metal Free

A facile metal-free one-pot exo-stereoselective synthesis of through two sequential organobase-catalysed 1,4-conjugate additions of pyran-2,4-diones on diarylideneacetone synthons is disclosed.

Stereoselective synthesis of alkyl styryl selenides in one-pot: a straightforward approach by in situ dialkyl diselenide formation under transition metal-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (128) ◽  
pp. 105699-105706 ◽  
Author(s):  
Adrián A. Heredia ◽  
Alicia B. Peñéñory
Keyword(s):  
Transition Metal ◽  
Stereoselective Synthesis ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Straightforward Approach

One-pot synthesis of alkyl styryl selenides using KSeCN as selenium source.

Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex

2020 ◽  
Author(s):  
José Tiago Menezes Correia ◽  
Gustavo Piva da Silva ◽  
Camila Menezes Kisukuri ◽  
Elias André ◽  
Bruno Pires ◽  
...  
Keyword(s):  
Electron Donor ◽  
Functional Group ◽  
Photoexcited Electron ◽  
One Pot ◽  
Quaternary Centers ◽  
Metal Free ◽  
Acceptor Complex ◽  
Catalyst Free ◽  
Donor Acceptor ◽  
Radical Cascade

A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and step-economical approach to the construction of diversely functionalized dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization approach is also allowed giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.

Metal-Free Photoredox-Catalyzed C–H/C–H Coupling of Arenes Enabled by Interrupted Pummerer Activation

2019 ◽  
Author(s):  
Miles Aukland ◽  
Mindaugas Šiaučiulis ◽  
Adam West ◽  
Gregory Perry ◽  
David Procter
Keyword(s):  
Natural Product ◽  
Selective Reduction ◽  
Cross Coupling ◽  
One Pot ◽  
Complex Molecules ◽  
Pummerer Reaction ◽  
Metal Free ◽  
Bond Forming ◽  
Coupling Partner ◽  
Bioactive Natural Product

<p>Aryl–aryl cross-coupling constitutes one of the most widely used procedures for the synthesis of high-value materials, ranging from pharmaceuticals to organic electronics and conducting polymers. The assembly of (hetero)biaryl scaffolds generally requires multiple steps; coupling partners must be functionalized before the key bond-forming event is considered. Thus, the development of selective C–H arylation processes in arenes, that side-step the need for prefunctionalized partners, is crucial for streamlining the construction of these key architectures. Here we report an expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners. The approach is underpinned by the activation of a C–H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy is exemplified by the synthesis of a bioactive natural product and the modification of complex molecules of societal importance.</p>

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

Metal-Free Synthesis of 1,2,4-Triazines via a Coupled Domino Process in One-Pot

2016 ◽  
Vol 21 (2) ◽  
pp. 183-188
Author(s):  
Jing Wang ◽  
Dong Tang ◽  
Zhuo-Mei Li ◽  
Ping Wu ◽  
Xu Meng ◽  
...  
Keyword(s):  
One Pot ◽  
Metal Free

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

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