Asymmetric copper-catalyzed fluorination of cyclic β-keto esters in a continuous-flow microreactor

2020 ◽  
Vol 18 (26) ◽  
pp. 4927-4931
Author(s):  
Yi-Feng Wang ◽  
Zhen-Hui Jiang ◽  
Ming-Ming Chu ◽  
Suo-Suo Qi ◽  
Hao Yin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Keto Esters ◽  
Flow Microreactor

A highly enantioselective fluorination using diphenylamine linked bis(oxazoline)–Cu(OTf)2 complexes as a catalyst under continuous-flow conditions has been established.

scholarly journals Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

2020 ◽  
Vol 16 ◽  
pp. 1305-1312
Author(s):  
Alexander V Nyuchev ◽  
Ting Wan ◽  
Borja Cendón ◽  
Carlo Sambiagio ◽  
Job J C Struijs ◽  
...  
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Reaction Yield ◽  
Flow Conditions ◽  
Flow Microreactor ◽  
Microreactor Technology

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

A monolithic 5-(pyrrolidin-2-yl)tetrazole flow microreactor for the asymmetric aldol reaction in water–ethanol solvent

2016 ◽  
Vol 1 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Roberto Greco ◽  
Lorenzo Caciolli ◽  
Anna Zaghi ◽  
Omar Pandoli ◽  
Olga Bortolini ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Monolithic Column ◽  
Aldol Reaction ◽  
Flow Conditions ◽  
Asymmetric Aldol ◽  
Long Term Stability ◽  
Flow Microreactor ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water

An organocatalytic polystyrene monolithic column produces chiral β-hydroxyketones under benign, continuous-flow conditions with high long-term stability.

Metal–organic frameworks for the removal of the emerging contaminant atenolol under real conditions

2021 ◽  
Vol 50 (7) ◽  
pp. 2493-2500
Author(s):  
Sara Rojas ◽  
Jorge A. R. Navarro ◽  
Patricia Horcajada
Keyword(s):  
Continuous Flow ◽  
Metal Organic Frameworks ◽  
Fixed Bed ◽  
Emerging Contaminant ◽  
Flow Conditions ◽  
Metal Organic ◽  
Fixed Bed System

A defective Metal-Organic Frameworks as an improved material for the construction of a fixed-bed system working under continuous flow conditions for the removal of the emerging contaminant atenolol.

scholarly journals Formation and Utility of Reactive Ketene Intermediates Under Continuous Flow Conditions

Tetrahedron ◽  
2021 ◽  
pp. 132305
Author(s):  
Harry R. Smallman ◽  
Jamie A. Leitch ◽  
Tom McBride ◽  
Steven V. Ley ◽  
Duncan L. Browne
Keyword(s):  
Continuous Flow ◽  
Flow Conditions

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

Transformation of 1-Butene over Synthetic Zeolites

1992 ◽  
Vol 57 (4) ◽  
pp. 869-881 ◽  
Author(s):  
Italo Ferino ◽  
Roberto Monaci ◽  
Vincenzo Solinas ◽  
Lucio Forni ◽  
Antonio Rivoldini ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Flow ◽  
Liquid Mixture ◽  
Isomerization Reaction ◽  
Reaction Conditions ◽  
Title Reaction ◽  
Y Zeolites ◽  
Temperature Range ◽  
Flow Microreactor ◽  
Synthetic Zeolites

The behaviour of several zeolites as catalysts for the title reaction has been investigated by means of a continuous flow microreactor. Runs performed at atmospheric pressure indicated that at 423 K the completely protonic forms of the zeolites catalyze just the isomerization reaction. In the case of Y zeolites, oligomerization occurs only over the partially decationated samples, in the temperature range between 373 and 423 K and W/F between 0.2 and 22 gcath/g1-but, to an extent which depends on the reaction conditions. Most of the catalysts were tested also under pressure (4.05 MPa) at 423 K. The protonic forms of Y and ZSM-5 zeolites seem promising catalysts in terms of both conversion and selectivity to oligomers. The 1-olefins account for 30% of the entire olefinic mixture. The octenes, which account for 70% of the liquid mixture, are mostly formed of dimethylhexenes. Trimers are also formed during the reaction and, in the very particular case of H[B]ZSM-5, tetramers are produced.

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