A monolithic 5-(pyrrolidin-2-yl)tetrazole flow microreactor for the asymmetric aldol reaction in water–ethanol solvent

2016 ◽  
Vol 1 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Roberto Greco ◽  
Lorenzo Caciolli ◽  
Anna Zaghi ◽  
Omar Pandoli ◽  
Olga Bortolini ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Monolithic Column ◽  
Aldol Reaction ◽  
Flow Conditions ◽  
Asymmetric Aldol ◽  
Long Term Stability ◽  
Flow Microreactor ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water

An organocatalytic polystyrene monolithic column produces chiral β-hydroxyketones under benign, continuous-flow conditions with high long-term stability.

Enhanced Activity and Stereoselectivity of Polystyrene-Supported Proline-Based Organic Catalysts for Direct Asymmetric Aldol Reaction in Water

2009 ◽  
Vol 2009 (31) ◽  
pp. 5437-5444 ◽  
Author(s):  
Michelangelo Gruttadauria ◽  
Anna Maria Pia Salvo ◽  
Francesco Giacalone ◽  
Paola Agrigento ◽  
Renato Noto
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Aldol ◽  
Enhanced Activity ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water ◽  
Organic Catalysts

scholarly journals Synthesis of New Di- and Triamides as Potential Organocatalysts for Asymmetric Aldol Reaction in Water

2020 ◽  
Vol 67 (4) ◽  
pp. 1014-1023
Author(s):  
Elif Keskin ◽  
Cigdem Yolacan ◽  
Feray Aydogan
Keyword(s):  
Benzoic Acid ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Reaction Conditions ◽  
Asymmetric Aldol ◽  
Co Catalyst ◽  
Aliphatic Ketones ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water

New di- or triamide organocatalysts derived from (L)-proline were synthesized and successfully used in the direct asymmetric aldol reaction of aliphatic ketones and aromatic aldehydes in water at 0 °C in the presence of benzoic acid as co-catalyst. (S)-methyl-2-((S)-3-hydroxy-2-((S)-3-pyrrolidine-2-carboxamido)propanamido)-3-phenylpropanoate (7c) as organocatalyst showed best results under these reaction conditions, and good diastereoselectivities (up to 99%), enantioselectivities (up to 98%) and yields (up to 91%) were observed.

The small peptide-catalyzed direct asymmetric aldol reaction in water

2006 ◽  
Vol 4 (1) ◽  
pp. 38-40 ◽  
Author(s):  
Pawel Dziedzic ◽  
Weibiao Zou ◽  
Jonas Háfren ◽  
Armando Córdova
Keyword(s):  
Aldol Reaction ◽  
Small Peptide ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Reaction In Water

Thermoresponsive Polymer-Supported l-Proline Micelle Catalysts for the Direct Asymmetric Aldol Reaction in Water

2013 ◽  
Vol 2 (4) ◽  
pp. 327-331 ◽  
Author(s):  
Hazit A. Zayas ◽  
Annhelen Lu ◽  
David Valade ◽  
Faheem Amir ◽  
Zhongfan Jia ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Thermoresponsive Polymer ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Polymer Supported ◽  
Reaction In Water
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