A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

2020 ◽  
Vol 18 (18) ◽  
pp. 3466-3470
Author(s):  
Chaoqun Ao ◽  
Jingjing Huang ◽  
Xinfang Xu ◽  
Shikun Jia ◽  
Zhenghui Kang ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Efficient Approach ◽  
Pyrazolone Derivatives ◽  
Three Component Reaction ◽  
Quaternary Stereocenters

Efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

scholarly journals Diastereoselective synthesis of dispirooxindoles via [3+2] cycloaddition of azomethine ylides to 3-phenacylideneoxindoles and evaluation of their cytotoxicity

RSC Advances ◽  
2018 ◽  
Vol 8 (42) ◽  
pp. 23990-23995 ◽  
Author(s):  
Ying Huang ◽  
Yi-Xin Huang ◽  
Jing Sun ◽  
Chao-Guo Yan
Keyword(s):  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Diastereoselective Synthesis ◽  
Three Component Reaction

The three-component reaction of 1,2,3,4-tetrahydroisoquinoline, isatins and 3-phenacylideneoxindoles in refluxing ethanol afforded dispiro[indoline-3,1′-pyrrolo[2,1-a]isoquinoline-3′,3′-indolines] (4a–4x) in good yields via 1,3-dipolar cycloaddition.

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

ChemInform Abstract: A Simple and Efficient Approach to the Synthesis of 4H-Furo[3,4-b]pyrans via a Three-Component Reaction of Isocyanides.

ChemInform ◽  
2008 ◽  
Vol 39 (48) ◽  
Author(s):  
Ahmad Shaabani ◽  
Ebrahim Soleimani ◽  
Afshin Sarvary ◽  
Ali Hossein Rezayan
Keyword(s):  
Efficient Approach ◽  
Three Component Reaction

Trapping of carbolithiation-derived tertiary benzylic α-lithio piperidines with carbon electrophiles: Controlling the formation of α-amino quaternary and vicinal stereocenters

2015 ◽  
Vol 13 (32) ◽  
pp. 8647-8651 ◽  
Author(s):  
Timothy K. Beng ◽  
Nathan Fox ◽  
Daniel P. Bassler ◽  
Amir Alwali ◽  
Kayla Sincavage ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Quaternary Stereocenters

The interception of carbolithiation-derived tertiary benzylic α-lithio piperidines with carbon electrophiles has led to the diastereoselective synthesis of vicinally functionalized piperidines bearing α-amino quaternary stereocenters.

ChemInform Abstract: An Efficient and Diastereoselective Synthesis of Hydrazino Amides via a Novel One-Pot Three-Component Reaction.

ChemInform ◽  
2013 ◽  
Vol 44 (35) ◽  
pp. no-no
Author(s):  
Sorour Ramezanpour ◽  
Saeed Balalaie ◽  
Frank Rominger ◽  
Hamid Reza Bijanzadeh
Keyword(s):  
Diastereoselective Synthesis ◽  
One Pot ◽  
Three Component Reaction

Diastereoselective Synthesis of β-Lactam-Oxindole Hybrids Through a Three-Component Reaction of Azetidine-2,3-diones, α-Diazo-oxindoles, and Alcohols Catalyzed by [Rh2(OAc)4]

2012 ◽  
Vol 2012 (12) ◽  
pp. 2359-2366 ◽  
Author(s):  
Benito Alcaide ◽  
Pedro Almendros ◽  
Cristina Aragoncillo ◽  
Ricardo Callejo ◽  
M. Pilar Ruiz ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Three Component Reaction

ChemInform Abstract: An Efficient Diastereoselective Synthesis of Spiro Pyrido[2,1-b][1,3]oxazines via a Novel Pyridine-Based Three-Component Reaction.

ChemInform ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. no-no
Author(s):  
Abbas Ali Esmaeili ◽  
Hamid Vesalipoor ◽  
Rahele Hosseinabadi ◽  
Alireza Fakhari Zavareh ◽  
Mohammad Ali Naseri ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Three Component Reaction

Cyclopropanes in water: a diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes

2016 ◽  
Vol 18 (7) ◽  
pp. 2201-2205 ◽  
Author(s):  
Ashish Anand ◽  
Jayashree Yenagi ◽  
J. Tonannavar ◽  
Manohar V. Kulkarni
Keyword(s):  
Aromatic Aldehydes ◽  
Diastereoselective Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
Substituted Cyclopropanes

A one-pot three component reaction has been developed for the synthesis of substituted cyclopropanes employing 4-bromomethyl-2H-chromen-2-one/quinolin-2(1H)-ones, aromatic aldehydes and activated nitriles.

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