ChemInform Abstract: A Simple and Efficient Approach to the Synthesis of 4H-Furo[3,4-b]pyrans via a Three-Component Reaction of Isocyanides.

ChemInform ◽  
2008 ◽  
Vol 39 (48) ◽  
Author(s):  
Ahmad Shaabani ◽  
Ebrahim Soleimani ◽  
Afshin Sarvary ◽  
Ali Hossein Rezayan
Keyword(s):  
Efficient Approach ◽  
Three Component Reaction

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

One-Pot Synthesis of Functionalised 4-Spiro-1,4-Dihydropyridines Via [1+2+1+2]-Cyclisation

2017 ◽  
Vol 41 (9) ◽  
pp. 513-516 ◽  
Author(s):  
Pan Zhou ◽  
Biao Hu ◽  
Lingling Lu ◽  
Rong Huang ◽  
Fuchao Yu
Keyword(s):  
Acetic Acid ◽  
Ammonium Acetate ◽  
Water Solution ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Approach ◽  
H Nmr ◽  
Three Component Reaction ◽  
C Nmr ◽  
Operational Simplicity

A simple and efficient approach for the synthesis of 4-spiro-1,4-DHP derivatives has been developed, involving one-pot three-component reaction of isatins, N,N-dimethylenaminones with ammonium acetate in EtOH–water solution promoted by acetic acid. Compared with the previous [1+2+3]-cyclisation method, this [1+2+1+2]-cyclisation procedure has advantages as it is more environmentally friendly, has easier operational simplicity, and requires milder reaction conditions. Moreover, these novel compounds have been obtained in moderate to good yields and their structures have been confirmed by 1H NMR, 13C NMR and IR and HRMS spectroscopy.

A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

2015 ◽  
Vol 13 (35) ◽  
pp. 9181-9185 ◽  
Author(s):  
Yuvaraj Dommaraju ◽  
Shruti Bora ◽  
Dipak Prajapati
Keyword(s):  
Aromatic Aldehyde ◽  
Domino Reaction ◽  
Pyrimidine Derivatives ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
First Time

A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished for the first-time by a three-component reaction involving alkylsulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil.

Organocatalytic multicomponent synthesis of polysubstituted pyrroles from 1,2-diones, aldehydes and arylamines

2015 ◽  
Vol 51 (93) ◽  
pp. 16652-16655 ◽  
Author(s):  
Yin Zheng ◽  
Youming Wang ◽  
Zhenghong Zhou
Keyword(s):  
Multicomponent Synthesis ◽  
Efficient Approach ◽  
Three Component Reaction

We have developed an organocatalyzed three-component reaction of 1,2-diones, aldehydes and arylamines, which provides an efficient approach to access polysubstituted pyrroles.

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