Manganese-doped gold core mesoporous silica particles as a nanoplatform for dual-modality imaging and chemo-chemodynamic combination osteosarcoma therapy

Nanoscale ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 5077-5093 ◽  
Author(s):  
Zhou Sha ◽  
Shuguang Yang ◽  
Liwen Fu ◽  
Mengru Geng ◽  
Jiani Gu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Combination Therapy ◽  
Mr Imaging ◽  
Mesoporous Silica ◽  
Silica Particles ◽  
Dual Modality ◽  
Prepared Nanoparticles ◽  
Gold Core ◽  
Dual Modality Imaging

The as-prepared nanoparticles integrate bone targeted chem-chemodynamic combination therapy and dual-modality computed tomography/magnetic resonance (CT/MR) imaging into a single platform.

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

scholarly journals Dual-Modality Imaging of Cancer with SPECT/CT

2002 ◽  
Vol 1 (6) ◽  
pp. 449-458 ◽  
Author(s):  
Bruce H. Hasegawa ◽  
Kenneth H. Wong ◽  
Koji Iwata ◽  
William C. Barber ◽  
Andrew B. Hwang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Em Algorithm ◽  
Photon Emission ◽  
Imaging Systems ◽  
Patient Specific ◽  
Emission Computed Tomography ◽  
Functional Information ◽  
Dual Modality ◽  
Photon Attenuation ◽  
Dual Modality Imaging

Dual-modality imaging is an in vivo diagnostic technique that obtains structural and functional information directly from patient studies in a way that cannot be achieved with separate imaging systems alone. Dual-modality imaging systems are configured by combining computed tomography (CT) with radionuclide imaging (using positron emission tomography (PET) or single-photon emission computed tomography (SPECT)) on a single gantry which allows both functional and structural imaging to be performed during a single imaging session without having the patient leave the imaging system. A SPECT/CT system developed at UCSF is being used in a study to determine if dual-modality imaging offers advantages for assessment of patients with prostate cancer using111 In-ProstaScint®, a radiolabeled antibody for the prostate-specific membrane antigen.111 In-ProstaScint® images are reconstructed using an iterative maximum-likelihood expectation-maximization (ML-EM) algorithm with correction for photon attenuation using a patient-specific map of attenuation coefficients derived from CT. The ML-EM algorithm accounts for the dual-photon nature of the111 In-labeled radionuclide, and incorporates correction for the geometric response of the radionuclide collimator. The radionuclide image then can be coregistered and overlaid in color on a grayscale CT image for improved localization of the functional information from SPECT. Radionuclide images obtained with SPECT/CT and reconstructed using ML-EM with correction for photon attenuation and collimator response improve image quality in comparison to conventional radionuclide images obtained with filtered backprojection reconstruction. These results illustrate the potential advantages of dual-modality imaging for improving the quality and the localization of radionuclide uptake for staging disease, planning treatment, and monitoring therapeutic response in patients with cancer.

Preparation of Gd-Au Dendrimer-Entrapped Gold Nanoparticles-Folic Acid Nanoparticles and Its Application in Computed Tomography/Magnetic Resonance Imaging Dual-Modality Diagnosis of Abdominal Tumors

2021 ◽  
Vol 13 (7) ◽  
pp. 1364-1373
Author(s):  
Yumei Zhang ◽  
Ruina Pei ◽  
Tao Luo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Receptor Expression ◽  
Average Particle ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Abdominal Tumors

ABSTRACTThe development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2 oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution. When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression. During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body and further used for the early diagnosis of abdominal tumors.

scholarly journals Additional Diagnostic Value of Unenhanced Computed Tomography plus Diffusion-Weighted Imaging Combined with Routine Magnetic Resonance Imaging Findings of Early-Stage Gliblastoma

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hexiang Wang ◽  
Zhenyou Liu ◽  
Yong Zhang ◽  
Feng Hou ◽  
Weiwei Fu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Diffusion Weighted Imaging ◽  
Early Stage ◽  
Diagnostic Value ◽  
Imaging Findings ◽  
Hyperintense Lesion ◽  
Unenhanced Ct ◽  
Unenhanced Computed Tomography

Purpose. This study was performed to determine whether diffusion-weighted imaging (DWI) plus unenhanced computed tomography (CT) of the brain increases the diagnostic value of routine magnetic resonance (MR) imaging findings of early-stage glioblastoma. Methods. Postcontrast MR images of eight unenhanced lesions that had been pathologically diagnosed as glioblastoma were retrospectively examined. The location, margin, signal intensity, and attenuation on MR imaging and CT were assessed. Results. On MR imaging, all lesions were ill-defined, small, and isointense to hypointense on T1-weighted images and hyperintense on T2-weighted images. Four patients had perilesional edema. In seven patients, DWI showed an inhomogeneous hyperintense lesion (n = 1) or isointense lesion with a hyperintense region (n = 6). On unenhanced CT, all masses presented as a hypoattenuated lesion with a hyperattenuated region (n = 7) or isoattenuated region (n = 1). The hyperattenuated region (n = 6) or isoattenuated region (n = 1) on CT appeared on DWI as an inhomogeneous hyperintense lesion (n = 1), isointense lesion with a hyperintense region (n = 3), or ring-like peritumoral hyperintensity (n = 3). Conclusions. MR imaging was the most sensitive imaging method for depicting early-stage glioblastoma. The CT finding of a hyperattenuated or isoattenuated region combined with the DWI finding of the same region containing an inhomogeneous hyperintense lesion or isointense lesion with a hyperintense region may be a specific diagnostic sign for early-stage glioblastoma. DWI plus unenhanced CT added diagnostic value to the routine MR imaging findings of early-stage glioblastoma.

scholarly journals Multifocal Dysembryoplastic Neuroepithelial Tumour with Intradural Spinal Cord Lipomas: Report of a Case

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Richard D. White ◽  
Avinash K. Kanodia ◽  
Esther M. Sammler ◽  
John N. Brunton ◽  
Craig A. Heath
Keyword(s):  
Computed Tomography ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Natural History ◽  
Mr Imaging ◽  
Temporal Lobe Epilepsy ◽  
Imaging Findings ◽  
History Of ◽  
Thoracic Cord ◽  
Brown Sequard Syndrome

We report a case of temporal lobe epilepsy and incomplete Brown-Sequard syndrome of the thoracic cord. Computed tomography and magnetic resonance (MR) imaging showed multiple supratentorial masses with the classical radiological appearances of multifocal dysembryoplastic neuroepithelial tumour (DNET). Spinal MR imaging revealed intradural lipomas, not previously reported in association with multifocal DNET. Presentation and imaging findings are discussed along with classification and natural history of the tumour.

Dural damage due to a loosened hydroxyapatite intraspinous spacer after spinous process–splitting laminoplasty

2007 ◽  
Vol 7 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Atsushi Ono ◽  
Toru Yokoyama ◽  
Takuya Numasawa ◽  
Kanichiro Wada ◽  
Satoshi Toh
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Postoperative Complications ◽  
Mr Imaging ◽  
Nerve Root ◽  
Spinous Process ◽  
Imaging Studies ◽  
Dural Sac ◽  
Neck And Shoulder Pain ◽  
Axial Pain

✓Excellent results from laminoplasty for cervical spinal myelopathy have been reported in many studies. Nevertheless, C-5 nerve root palsy or axial pain such as neck and shoulder pain after laminoplasty are known postoperative complications. To the authors' knowledge, dural damage from dislocation of the hydroxyapatite intraspinous spacer due to absorption of the tip of the spinous process has not been reported. Two cases of dural damage from dislocation of the hydroxyapatite intraspinous spacer after laminoplasty are described. Radiographs, computed tomography myelography, and magnetic resonance (MR) imaging revealed the dislocation of the hydroxyapatite intraspinous spacer, the absorption of the tip of the spinous process, and dural sac compression due to the hydroxyapatite intraspinous spacer. In one patient, the MR imaging studies revealed liquorrhea around the hydroxyapatite intraspinous spacers. Both patients underwent removal of the hydroxyapatite intraspinous spacer and attained good neurological recovery. In patients with dislocation of the hydroxyapatite intraspinous spacer associated with absorption of the tip of the spinous process after spinous process–splitting laminoplasty, each case should be evaluated for aggravating symptoms of myelopathy, dural damage, and liquorrhea around the spacer.

Sign in / Sign up

Export Citation Format

Share Document